Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
39  structures 14157  species 3  interactions 18612  sequences 119  architectures

Clan: 2H (CL0247)


2H phosphoesterase superfamily Add an annotation

This clan includes a number of phosphoesterases that contain an internal duplication.

This clan contains 9 families and the total number of domains in the clan is 18612. The clan was built by A Bateman.

Literature references

  1. Mazumder R, Iyer LM, Vasudevan S, Aravind L; , Nucleic Acids Res 2002;30:5229-5243.: Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily. PUBMED:12466548 EPMC:12466548


This clan contains the following 9 member families:

2_5_RNA_ligase2 2H-phosphodiest AKAP7_NLS CNPase Corona_NS2A CPDase DUF1045 HVSL LigT_PEase

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
2_5_RNA_ligase2 (PF13563) 10745 (57.7%) View
LigT_PEase (PF02834) 4805 (25.8%) View
AKAP7_NLS (PF10469) 794 (4.3%) View
DUF1045 (PF06299) 727 (3.9%) View
HVSL (PF09749) 554 (3.0%) View
2H-phosphodiest (PF08975) 487 (2.6%) View
CPDase (PF07823) 258 (1.4%) View
Corona_NS2A (PF05213) 133 (0.7%) View
CNPase (PF05881) 109 (0.6%) View
Total: 9 Total: 18612 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
CNPase CNPase
CPDase CPDase
LigT_PEase LigT_PEase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...