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200  structures 6742  species 16  interactions 56235  sequences 651  architectures

Clan: 2heme_cytochrom (CL0328)


Transmembrane di-heme cytochrome superfamily Add an annotation

This superfamily includes a variety of different heme binding cytochromes.

This clan contains 9 families and the total number of domains in the clan is 56235. The clan was built by A Bateman.


This clan contains the following 9 member families:

COX15-CtaA Cytochrom_B561 Cytochrom_B_N_2 Cytochrom_C_asm Cytochrome_B DUF2427 DUF4405 Ferric_reduct Ni_hydr_CYTB

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ferric_reduct (PF01794) 15631 (27.8%) View
Cytochrom_C_asm (PF01578) 11346 (20.2%) View
Ni_hydr_CYTB (PF01292) 9456 (16.8%) View
COX15-CtaA (PF02628) 6349 (11.3%) View
Cytochrom_B561 (PF03188) 6007 (10.7%) View
Cytochrome_B (PF00033) 3728 (6.6%) View
Cytochrom_B_N_2 (PF13631) 1708 (3.0%) View
DUF2427 (PF10348) 1327 (2.4%) View
DUF4405 (PF14358) 683 (1.2%) View
Total: 9 Total: 56235 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 16 interactions for this clan. More...

Interacting families
Cytochrom_B_N_2 Cytochrom_B_C
Fer4_11 Cytochrome_B
Fer4_9 Cytochrome_B
Form-deh_trans Cytochrome_B
Peptidase_M16_C Cytochrom_B_N_2
Rieske Cytochrom_B_N_2
UCR_Fe-S_N Cytochrom_B_N_2
UCR_TM Cytochrom_B_N_2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...