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453  structures 22151  species 99  interactions 550967  sequences 2707  architectures

Clan: 4Fe-4S (CL0344)

Summary

4Fe-4S ferredoxins Add an annotation

Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.

This clan contains 25 families and the total number of domains in the clan is 550967. The clan was built by A Bateman.

Members

This clan contains the following 25 member families:

ETF_QO Fer4 Fer4_10 Fer4_11 Fer4_12 Fer4_13 Fer4_14 Fer4_15 Fer4_16 Fer4_17 Fer4_18 Fer4_19 Fer4_2 Fer4_20 Fer4_21 Fer4_3 Fer4_4 Fer4_5 Fer4_6 Fer4_7 Fer4_8 Fer4_9 FeS Molybdop_Fe4S4 RLI

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Fer4_12 (PF13353) 87224 (15.8%) View
Fer4_11 (PF13247) 61706 (11.2%) View
Fer4_7 (PF12838) 54730 (9.9%) View
Molybdop_Fe4S4 (PF04879) 48741 (8.8%) View
Fer4_8 (PF13183) 38959 (7.1%) View
Fer4_4 (PF12800) 31750 (5.8%) View
Fer4 (PF00037) 31315 (5.7%) View
Fer4_20 (PF14691) 29577 (5.4%) View
Fer4_10 (PF13237) 28306 (5.1%) View
Fer4_14 (PF13394) 22122 (4.0%) View
Fer4_5 (PF12801) 21838 (4.0%) View
Fer4_16 (PF13484) 15040 (2.7%) View
Fer4_17 (PF13534) 12893 (2.3%) View
continued
Pfam family Num. domains Alignment
Fer4_21 (PF14697) 12572 (2.3%) View
Fer4_9 (PF13187) 10269 (1.9%) View
FeS (PF04060) 8426 (1.5%) View
Fer4_15 (PF13459) 8265 (1.5%) View
Fer4_13 (PF13370) 7909 (1.4%) View
Fer4_18 (PF13746) 4951 (0.9%) View
ETF_QO (PF05187) 4581 (0.8%) View
Fer4_6 (PF12837) 4105 (0.7%) View
Fer4_19 (PF06902) 3056 (0.6%) View
RLI (PF04068) 1750 (0.3%) View
Fer4_3 (PF12798) 708 (0.1%) View
Fer4_2 (PF12797) 174 (0.0%) View
Total: 25 Total: 550967 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 99 interactions for this clan. More...

Interacting families
A B
Cna_B Fer4_11
Complex1_49kDa Fer4
DHO_dh Fer4_20
Fer4_21
eRF1_3 Fer4
RLI
FAD_binding_2 Fer4
Fer4_17
Fer4_8
Fer4_9
Fe_hyd_SSU Fer4
Fer2 Molybdop_Fe4S4
Fer2_3 Fer4_17
Fer4_8
Fer2_4 Molybdop_Fe4S4
Fer4 ABC_tran
APS-reductase_C
Cytochrom_C
Cytochrom_CIII
DUF3197
DUF3470
Fe_hyd_lg_C
Fe_hyd_SSU
Fer4
FrhB_FdhB_C
NADH_Oxid_Nqo15
NrfD_2
PsaD
PSI_PsaE
TPP_enzyme_C
Fer4_11 Cna_B
Cytochrome_B
Fer4
Fer4_9
Form-deh_trans
Molydop_binding
Nitr_red_bet_C
Nitrate_red_gam
NrfD_2
Fer4_12 Radical_SAM
Wyosine_form
Fer4_13 Fer4_13
Fer4_14 Mob_synth_C
Fer4_17 CybS
Sdh_cyt
Fer4_20 DHO_dh
Fer4_20
Fer4_21
NAD_binding_8
Pyr_redox
Pyr_redox_2
Fer4_21 DHO_dh
Fer4_20
Fer4_9
Fer4_4 Fer4
Fer4_7 CO_dh
Fer4_7
PsaD
PSI_PsaE
Fer4_8 Fumarate_red_C
Fumarate_red_D
Sdh_cyt
Fer4_9 APS-reductase_C
Cytochrome_B
Form-deh_trans
PsaD
PSI_PsaE
FeS CdhD
Glu_syn_central Fer4_20
Glu_synthase Fer4_20
Molybdop_Fe4S4 Fer4
Fer4_11
Fer4_9
Molybdop_Fe4S4
Molybdopterin
Molydop_binding
NapB
Molybdopterin Fer4_11
Fer4_9
Molybdop_Fe4S4
Molydop_binding Fer4_11
NADH-G_4Fe-4S_3 Fer4
NADH_Oxid_Nqo15 Fer4
NapB Molybdop_Fe4S4
NIR_SIR Fer4
Nitr_red_alph_N Fer4_11
Oxidored_q6 Fer4
Prismane Fer4_7
PsaA_PsaB Fer4
Fer4_21
Fer4_7
Fer4_9
Pterin_bind FeS
Radical_SAM Fer4_12
Fer4_14
RLI ABC_tran
Fer4
Sdh_cyt Fer4_8
Succ_DH_flav_C Fer4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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