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444  structures 147  species 74  interactions 4665  sequences 83  architectures

Clan: 4H_Cytokine (CL0053)


4-helical cytokine superfamily Add an annotation

Cytokines are regulatory peptides that can be produced by various cells for communicating and orchestrating the large multicellular system. Cytokines are key mediators of hematopoiesis, immunity, allergy, inflammation, tissue remodeling, angiogenesis, and embryonic development [2]. This superfamily includes both the long and short chain helical cytokines.

This clan contains 29 families and the total number of domains in the clan is 4665. The clan was built by A Bateman.

Literature references

  1. Hill EE, Morea V, Chothia C; , J Mol Biol 2002;322:205-233.: Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes. PUBMED:12215425 EPMC:12215425
  2. Ouyang S, He F; , J Mol Evol 2003;56:131-136.: Phylogeny of a growth hormone-like cytokine superfamily based upon 3D structure. PUBMED:12574859 EPMC:12574859


This clan contains the following 29 member families:

CNTF CSF-1 EPO_TPO Flt3_lig GCSF GM_CSF Hormone_1 IFN-gamma IL10 IL11 IL12 IL13 IL15 IL2 IL22 IL23 IL28A IL3 IL34 IL4 IL5 IL6 IL7 Interferon Leptin LIF_OSM PRF SCF TSLP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Interferon (PF00143) 792 (17.0%) View
Hormone_1 (PF00103) 746 (16.0%) View
IL10 (PF00726) 308 (6.6%) View
IL15 (PF02372) 247 (5.3%) View
EPO_TPO (PF00758) 208 (4.5%) View
SCF (PF02404) 185 (4.0%) View
IL28A (PF15177) 168 (3.6%) View
LIF_OSM (PF01291) 151 (3.2%) View
IL6 (PF00489) 149 (3.2%) View
PRF (PF06875) 138 (3.0%) View
IL7 (PF01415) 134 (2.9%) View
IL12 (PF03039) 127 (2.7%) View
IL4 (PF00727) 118 (2.5%) View
CSF-1 (PF05337) 110 (2.4%) View
IFN-gamma (PF00714) 109 (2.3%) View
Pfam family Num. domains Alignment
IL22 (PF14565) 107 (2.3%) View
IL34 (PF15036) 94 (2.0%) View
GCSF (PF16647) 91 (2.0%) View
IL5 (PF02025) 90 (1.9%) View
CNTF (PF01110) 88 (1.9%) View
IL11 (PF07400) 80 (1.7%) View
Leptin (PF02024) 75 (1.6%) View
Flt3_lig (PF02947) 71 (1.5%) View
IL2 (PF00715) 55 (1.2%) View
IL13 (PF03487) 52 (1.1%) View
GM_CSF (PF01109) 49 (1.1%) View
IL23 (PF16649) 48 (1.0%) View
TSLP (PF15216) 43 (0.9%) View
IL3 (PF02059) 32 (0.7%) View
Total: 29 Total: 4665 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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