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745  structures 4242  species 51  interactions 61350  sequences 1384  architectures

Clan: 6_Hairpin (CL0059)


Six-hairpin glycosidase superfamily Add an annotation

This Clan includes CAZy clans GH-L, GH-M and GH-G. The members of this clan share a common structure composed of 6 helical hairpins. Most members of this superfamily are glycosyl hydrolase enzymes.

This clan contains 27 families and the total number of domains in the clan is 61350. The clan was built by A Bateman.


This clan contains the following 27 member families:

A2M_comp Bac_rhamnosid6H C5-epim_C Cobalamin_bind DUF608 GDE_C GlcNAc_2-epim Glyco_hydro_100 Glyco_hydro_125 Glyco_hydro_127 Glyco_hydro_15 Glyco_hydro_36 Glyco_hydro_47 Glyco_hydro_48 Glyco_hydro_63 Glyco_hydro_65m Glyco_hydro_76 Glyco_hydro_8 Glyco_hydro_88 Glyco_hydro_9 Glycoamylase LANC_like Pec_lyase Prenyltrans SQHop_cyclase_C SQHop_cyclase_N Trehalase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Prenyltrans (PF00432) 12588 (20.5%) View
Glyco_hydro_47 (PF01532) 5088 (8.3%) View
Glyco_hydro_15 (PF00723) 4318 (7.0%) View
Glyco_hydro_88 (PF07470) 3283 (5.4%) View
Glyco_hydro_9 (PF00759) 3081 (5.0%) View
Bac_rhamnosid6H (PF17389) 2850 (4.6%) View
Glyco_hydro_76 (PF03663) 2773 (4.5%) View
Trehalase (PF01204) 2644 (4.3%) View
Glyco_hydro_127 (PF07944) 2236 (3.6%) View
SQHop_cyclase_C (PF13243) 2212 (3.6%) View
Glyco_hydro_65m (PF03632) 2125 (3.5%) View
A2M_comp (PF07678) 1998 (3.3%) View
GDE_C (PF06202) 1981 (3.2%) View
LANC_like (PF05147) 1911 (3.1%) View
Pfam family Num. domains Alignment
SQHop_cyclase_N (PF13249) 1907 (3.1%) View
GlcNAc_2-epim (PF07221) 1883 (3.1%) View
Glyco_hydro_63 (PF03200) 1555 (2.5%) View
Glyco_hydro_36 (PF17167) 1263 (2.1%) View
Glyco_hydro_125 (PF06824) 1115 (1.8%) View
Glycoamylase (PF10091) 999 (1.6%) View
DUF608 (PF04685) 932 (1.5%) View
Glyco_hydro_100 (PF12899) 804 (1.3%) View
Glyco_hydro_8 (PF01270) 762 (1.2%) View
C5-epim_C (PF06662) 368 (0.6%) View
Cobalamin_bind (PF01122) 265 (0.4%) View
Pec_lyase (PF09492) 225 (0.4%) View
Glyco_hydro_48 (PF02011) 184 (0.3%) View
Total: 27 Total: 61350 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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