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241  structures 4906  species 8  interactions 47783  sequences 221  architectures

Clan: ACT (CL0070)

Summary

ACT-like domain Add an annotation

These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains [1]. The relationship between these two families was first noticed in [2].

This clan contains 9 families and the total number of domains in the clan is 47783. The clan was built by A Bateman.

Literature references

  1. Anantharaman V, Koonin EV, Aravind L; , J Mol Biol 2001;307:1271-1292.: Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. PUBMED:11292341 EPMC:11292341
  2. Murzin AG, Bateman A; , Proteins 1997;1:105-112.: Distant homology recognition using structural classification of proteins. PUBMED:9485501 EPMC:9485501

Members

This clan contains the following 9 member families:

ACT ACT_3 ACT_4 ACT_5 ACT_6 ACT_7 DUF493 NikR_C Thr_dehydrat_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ACT (PF01842) 20885 (43.7%) View
ACT_7 (PF13840) 6068 (12.7%) View
ACT_4 (PF13291) 5583 (11.7%) View
ACT_5 (PF13710) 4946 (10.4%) View
Thr_dehydrat_C (PF00585) 4280 (9.0%) View
ACT_6 (PF13740) 3060 (6.4%) View
DUF493 (PF04359) 1622 (3.4%) View
NikR_C (PF08753) 1066 (2.2%) View
ACT_3 (PF10000) 273 (0.6%) View
Total: 9 Total: 47783 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 8 interactions for this clan. More...

Interacting families
A B
ACT_3 ACT_3
ACT 2-Hacid_dh
ACT
ALS_ss_C
Thr_dehydrat_C PALP
Thr_dehydrat_C
NikR_C RHH_1
NikR_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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