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946  structures 4393  species 33  interactions 14033  sequences 987  architectures

Clan: ADP-ribosyl (CL0084)


ADP-ribosylation Superfamily Add an annotation

The members of this clan all represent ADP-ribosylating catalytic domains. The structurally conserved regions are located at the NAD binding region [1]. According to SCOP, the ADP-ribosylation domain is thought to have an "unusual fold".

This clan contains 19 families and the total number of domains in the clan is 14033. The clan was built by RD Finn.

Literature references

  1. Ame JC, Spenlehauer C, de Murcia G; , Bioessays 2004;26:882-893.: The PARP superfamily. PUBMED:15273990 EPMC:15273990


This clan contains the following 19 member families:

ADPrib_exo_Tox ADPRTs_Tse2 Anthrax-tox_M Arr-ms ART ART-PolyVal AvrPphF-ORF-2 Diphtheria_C Dot_icm_IcmQ DUF2441 DUF952 Enterotoxin_a Exotox-A_cataly NADase_NGA PARP Pertussis_S1 PTS_2-RNA RolB_RolC TNT

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PARP (PF00644) 5835 (41.6%) View
PTS_2-RNA (PF01885) 2477 (17.7%) View
DUF952 (PF06108) 2183 (15.6%) View
ART (PF01129) 821 (5.9%) View
TNT (PF14021) 744 (5.3%) View
Arr-ms (PF12120) 617 (4.4%) View
ADPrib_exo_Tox (PF03496) 469 (3.3%) View
Enterotoxin_a (PF01375) 416 (3.0%) View
ART-PolyVal (PF18760) 129 (0.9%) View
Pertussis_S1 (PF02917) 94 (0.7%) View
DUF2441 (PF10386) 81 (0.6%) View
ADPRTs_Tse2 (PF18648) 51 (0.4%) View
RolB_RolC (PF02027) 37 (0.3%) View
Dot_icm_IcmQ (PF09475) 35 (0.2%) View
NADase_NGA (PF07461) 18 (0.1%) View
AvrPphF-ORF-2 (PF09143) 12 (0.1%) View
Exotox-A_cataly (PF09009) 8 (0.1%) View
Anthrax-tox_M (PF09156) 3 (0.0%) View
Diphtheria_C (PF02763) 3 (0.0%) View
Total: 19 Total: 14033 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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