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1816  structures 9252  species 0  interactions 340693  sequences 3243  architectures

Clan: Acetyltrans (CL0257)


N-acetyltransferase like Add an annotation

This clan contains families related to N-acetyltransferases. N-acetyltransferases catalyse the transfer of acetyl groups from acetyl-CoA to arylamines.

This clan contains 50 families and the total number of domains in the clan is 340693. The clan was built by J Mistry.

Literature references

  1. Chinenov Y; , Trends Biochem Sci 2002;27:115-117.: A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?. PUBMED:11893502 EPMC:11893502
  2. Kelley M, Vessey DA; , Biochem J 1992;288:315-317.: Structural comparison between the mitochondrial aralkyl-CoA and arylacetyl-CoA N-acyltransferases. PUBMED:1445276 EPMC:1445276


This clan contains the following 50 member families:

Acetyltransf_1 Acetyltransf_10 Acetyltransf_13 Acetyltransf_15 Acetyltransf_16 Acetyltransf_17 Acetyltransf_18 Acetyltransf_19 Acetyltransf_3 Acetyltransf_4 Acetyltransf_5 Acetyltransf_6 Acetyltransf_7 Acetyltransf_8 Acetyltransf_9 Acetyltransf_CG AstA ATE_C ATE_N Autoind_synth CFAP61_N DUF1122 DUF1248 DUF1999 DUF5613 DUF5645 FemAB FemAB_like FR47 Gly_acyl_tr_C GNAT_acetyltr_2 GNAT_acetyltran GNAT_C GNAT_like HAT_KAT11 HlyC Leu_Phe_trans LPG_synthase_C MCD Mig-14 MOZ_SAS NAT NMT NMT_C NodA ODC_AZ PanZ Phage_T7_Gp13 Pho86 T_hemolysin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Acetyltransf_1 (PF00583) 154452 (45.3%) View
Acetyltransf_3 (PF13302) 51560 (15.1%) View
Acetyltransf_10 (PF13673) 26587 (7.8%) View
Acetyltransf_7 (PF13508) 12386 (3.6%) View
Acetyltransf_6 (PF13480) 7098 (2.1%) View
MOZ_SAS (PF01853) 7072 (2.1%) View
Acetyltransf_CG (PF14542) 6125 (1.8%) View
LPG_synthase_C (PF09924) 4959 (1.5%) View
ATE_C (PF04377) 4954 (1.5%) View
ATE_N (PF04376) 4555 (1.3%) View
Acetyltransf_5 (PF13444) 4403 (1.3%) View
Acetyltransf_4 (PF13420) 4324 (1.3%) View
FR47 (PF08445) 4197 (1.2%) View
Leu_Phe_trans (PF03588) 4194 (1.2%) View
HAT_KAT11 (PF08214) 3746 (1.1%) View
Acetyltransf_8 (PF13523) 3674 (1.1%) View
GNAT_acetyltr_2 (PF13718) 3243 (1.0%) View
FemAB (PF02388) 3105 (0.9%) View
FemAB_like (PF04339) 2998 (0.9%) View
Acetyltransf_17 (PF17668) 2759 (0.8%) View
NMT_C (PF02799) 2656 (0.8%) View
NMT (PF01233) 2644 (0.8%) View
NAT (PF04768) 2115 (0.6%) View
Acetyltransf_18 (PF18014) 2030 (0.6%) View
MCD (PF05292) 1993 (0.6%) View
Acetyltransf_13 (PF13880) 1783 (0.5%) View
Pfam family Num. domains Alignment
ODC_AZ (PF02100) 1581 (0.5%) View
AstA (PF04958) 1476 (0.4%) View
Autoind_synth (PF00765) 1432 (0.4%) View
Acetyltransf_16 (PF05301) 1098 (0.3%) View
GNAT_acetyltran (PF12746) 1082 (0.3%) View
Gly_acyl_tr_C (PF08444) 760 (0.2%) View
CFAP61_N (PF16092) 738 (0.2%) View
GNAT_like (PF18407) 709 (0.2%) View
GNAT_C (PF18164) 464 (0.1%) View
T_hemolysin (PF12261) 330 (0.1%) View
HlyC (PF02794) 284 (0.1%) View
PanZ (PF12568) 240 (0.1%) View
Phage_T7_Gp13 (PF11090) 130 (0.0%) View
NodA (PF02474) 127 (0.0%) View
Mig-14 (PF07395) 112 (0.0%) View
DUF5613 (PF18467) 97 (0.0%) View
DUF1248 (PF06852) 96 (0.0%) View
Acetyltransf_19 (PF18015) 84 (0.0%) View
Pho86 (PF11124) 81 (0.0%) View
DUF5645 (PF18713) 69 (0.0%) View
DUF1122 (PF06557) 41 (0.0%) View
DUF1999 (PF09390) 26 (0.0%) View
Acetyltransf_15 (PF17013) 24 (0.0%) View
Acetyltransf_9 (PF13527) 0 (0.0%) View
Total: 50 Total: 340693
No alignment ℹ

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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