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1824  structures 5439  species 72  interactions 150464  sequences 1056  architectures

Clan: Actin_ATPase (CL0108)


Actin-like ATPase Superfamily Add an annotation

The actin-like ATPase domain forms an alpha/beta canonical fold. The domain can be subdivided into 1A, 1B, 2A and 2B subdomains. Subdomains 1A and 1B share the same RNAseH-like fold (a five-stranded beta-sheet decorated by a number of alpha-helices). Domains 1A and 2A are conserved in all members of this superfamily, whereas domain 1B and 2B have a variable structure and are even missing from some homologues [1]. Within the actin-like ATPase domain the ATP-binding site is highly conserved. The phosphate part of the ATP is bound in a cleft between subdomains 1A and 2A, whereas the adenosine moiety is bound to residues from domains 2A and 2B[1].

This clan contains 31 families and the total number of domains in the clan is 150464. The clan was built by RD Finn.

Literature references

  1. Abendroth J, Bagdasarian M, Sandkvist M, Hol WG; , J Mol Biol 2004;344:619-633.: The structure of the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae: an unusual member of the actin-like ATPase superfamily. PUBMED:15533433 EPMC:15533433


This clan contains the following 31 member families:

Acetate_kinase Actin Actin_micro AnmK BcrAD_BadFG Carbam_trans_N DDR DUF1464 DUF2229 EutA FGGY_C FGGY_N FtsA Fumble GDA1_CD39 Glucokinase Hexokinase_1 Hexokinase_2 HGD-D HSP70 Hydant_A_N Hydantoinase_A MreB_Mbl MutL Pan_kinase Peptidase_M22 PilM_2 Ppx-GppA ROK StbA T2SSL

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HSP70 (PF00012) 23151 (15.4%) View
Actin (PF00022) 14516 (9.6%) View
FGGY_N (PF00370) 13981 (9.3%) View
ROK (PF00480) 13910 (9.2%) View
FGGY_C (PF02782) 13544 (9.0%) View
Peptidase_M22 (PF00814) 10495 (7.0%) View
MreB_Mbl (PF06723) 5434 (3.6%) View
Ppx-GppA (PF02541) 5072 (3.4%) View
FtsA (PF14450) 4791 (3.2%) View
BcrAD_BadFG (PF01869) 4762 (3.2%) View
Acetate_kinase (PF00871) 4676 (3.1%) View
Hydantoinase_A (PF01968) 4578 (3.0%) View
Hydant_A_N (PF05378) 4307 (2.9%) View
Hexokinase_2 (PF03727) 3875 (2.6%) View
Hexokinase_1 (PF00349) 3650 (2.4%) View
GDA1_CD39 (PF01150) 3258 (2.2%) View
Pfam family Num. domains Alignment
Pan_kinase (PF03309) 2909 (1.9%) View
PilM_2 (PF11104) 2317 (1.5%) View
HGD-D (PF06050) 2091 (1.4%) View
AnmK (PF03702) 2049 (1.4%) View
Fumble (PF03630) 1775 (1.2%) View
Glucokinase (PF02685) 1452 (1.0%) View
DUF2229 (PF09989) 1130 (0.8%) View
Carbam_trans_N (PF02543) 1114 (0.7%) View
T2SSL (PF05134) 547 (0.4%) View
MutL (PF13941) 363 (0.2%) View
StbA (PF06406) 254 (0.2%) View
EutA (PF06277) 235 (0.2%) View
DDR (PF08841) 147 (0.1%) View
DUF1464 (PF07318) 56 (0.0%) View
Actin_micro (PF17003) 25 (0.0%) View
Total: 31 Total: 150464 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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