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703  structures 7275  species 4  interactions 30349  sequences 251  architectures

Clan: Arginase (CL0302)


Arginase/deacetylase superfamily Add an annotation

This superfamily includes arginase enzymes as well as histone deacetylases and related enzymes [1].

This clan contains 3 families and the total number of domains in the clan is 30349. The clan was built by A Bateman.

Literature references

  1. Dowling DP, Costanzo LD, Gennadios HA, Christianson DW; , Cell Mol Life Sci. 2008; [Epub ahead of print]: Evolution of the arginase fold and functional diversity. PUBMED:18360740 EPMC:18360740


This clan contains the following 3 member families:

Arginase Hist_deacetyl UPF0489

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Hist_deacetyl (PF00850) 16021 (52.8%) View
Arginase (PF00491) 13894 (45.8%) View
UPF0489 (PF12640) 434 (1.4%) View
Total: 3 Total: 30349 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
Arginase Arginase
ELM2 Hist_deacetyl
Hist_deacetyl Arb2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...