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576  structures 14395  species 4  interactions 42132  sequences 130  architectures

Clan: Arginase (CL0302)

Summary

Arginase/deacetylase superfamily Add an annotation

This superfamily includes arginase enzymes as well as histone deacetylases and related enzymes [1].

This clan contains 3 families and the total number of domains in the clan is 42132. The clan was built by A Bateman.

Literature references

  1. Dowling DP, Costanzo LD, Gennadios HA, Christianson DW; , Cell Mol Life Sci. 2008; [Epub ahead of print]: Evolution of the arginase fold and functional diversity. PUBMED:18360740 EPMC:18360740

Members

This clan contains the following 3 member families:

Arginase Hist_deacetyl UPF0489

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Arginase (PF00491) 25795 (61.2%) View
Hist_deacetyl (PF00850) 15804 (37.5%) View
UPF0489 (PF12640) 533 (1.3%) View
Total: 3 Total: 42132 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
Arginase Arginase
ELM2 Hist_deacetyl
Hist_deacetyl Arb2
Hist_deacetyl

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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