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277  structures 663  species 19  interactions 2927  sequences 47  architectures

Clan: BCLiA (CL0551)

Summary

Bcl-2 inhibitors of programmed cell death Add an annotation

This superfamily is characterised by families of proteins that inhibit apoptosis, They are regulated by all BH3-only proteins to promote apoptosis.

This clan contains 4 families and the total number of domains in the clan is 2927. The clan was built by P Coggill.

Literature references

  1. Korsmeyer SJ;, Cancer Res. 1999;59:1693.: BCL-2 gene family and the regulation of programmed cell death. PUBMED:10197582 EPMC:10197582
  2. Youle RJ, Strasser A;, Nat Rev Mol Cell Biol. 2008;9:47-59.: The BCL-2 protein family: opposing activities that mediate cell death. PUBMED:18097445 EPMC:18097445

Members

This clan contains the following 4 member families:

APG6 Atg14 Bcl-2 Bcl-2_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Bcl-2 (PF00452) 1188 (40.6%) View
Atg14 (PF10186) 898 (30.7%) View
APG6 (PF04111) 837 (28.6%) View
Bcl-2_3 (PF15286) 4 (0.1%) View
Total: 4 Total: 2927 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 19 interactions for this clan. More...

Interacting families
A B
APG6 APG6
Bcl-2 Bcl-2
Bcl-2_BAD
Bclx_interact
BH3
BH4
BID
BMF
CARD
EGL-1
NB-ARC
PMAIP1
SOUL
Bcl-2_3 Bcl-2_3
BH3
BH3 Bcl-2
BH4 Bcl-2
M11L Bcl-2
PMAIP1 Bcl-2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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