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961  structures 5474  species 14  interactions 58501  sequences 303  architectures

Clan: Beta-lactamase (CL0013)


Serine beta-lactamase-like superfamily Add an annotation

This superfamily contains proteins that have a beta-lactamase fold. This includes beta-lactamases as well as Dala-Dala carboxypeptidases and glutaminases.

This clan contains 7 families and the total number of domains in the clan is 58501. The clan was built by RD Finn and A Bateman.


This clan contains the following 7 member families:

Beta-lactamase Beta-lactamase2 DAP_B Glutaminase Peptidase_S11 Peptidase_S13 Transpeptidase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Transpeptidase (PF00905) 25088 (42.9%) View
Beta-lactamase (PF00144) 13942 (23.8%) View
Peptidase_S11 (PF00768) 8726 (14.9%) View
Beta-lactamase2 (PF13354) 5244 (9.0%) View
Peptidase_S13 (PF02113) 2907 (5.0%) View
Glutaminase (PF04960) 2528 (4.3%) View
DAP_B (PF07930) 66 (0.1%) View
Total: 7 Total: 58501 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 14 interactions for this clan. More...

Interacting families
Glutaminase Glutaminase
Peptidase_S13 Peptidase_S13
DAP_B Beta-lactamase
Peptidase_S11 Peptidase_S11
Beta-lactamase Beta-lactamase
Transpeptidase Transpeptidase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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