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184  structures 4165  species 11  interactions 19411  sequences 223  architectures

Clan: Beta-tent (CL0080)

Summary

Beta-tent fold Add an annotation

This clan contains TCTP, Mss4 and SelR families [1]. The common fold of members of this superfamily has been termed the beta-tent fold [2]. This fold contains two four stranded antiparallel beta sheets. These are oriented at right angles and pinned together at their tip by a zinc ion [2].

This clan contains 7 families and the total number of domains in the clan is 19411. The clan was built by A Bateman.

Literature references

  1. Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ; , Nat Struct Biol 2001;8:701-704.: Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones. PUBMED:11473261 EPMC:11473261
  2. Lupas AN, Zhu H, Korycinski M;, PLoS Comput Biol. 2015;11:e1004023.: The thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the beta-tent fold. PUBMED:25569776 EPMC:25569776

Members

This clan contains the following 7 member families:

GFA Mss4 NTP_transf_9 RIG-I_C-RD SelR TCTP Yippee-Mis18

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GFA (PF04828) 7168 (36.9%) View
SelR (PF01641) 5669 (29.2%) View
Yippee-Mis18 (PF03226) 2543 (13.1%) View
NTP_transf_9 (PF04248) 2234 (11.5%) View
TCTP (PF00838) 1047 (5.4%) View
RIG-I_C-RD (PF11648) 389 (2.0%) View
Mss4 (PF04421) 361 (1.9%) View
Total: 7 Total: 19411 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 11 interactions for this clan. More...

Interacting families
A B
DEAD RIG-I_C-RD
GFA GFA
Helicase_C RIG-I_C-RD
Mss4 Mss4
Ras
NTP_transf_9 NTP_transf_9
PMSR SelR
RIG-I_C-RD RIG-I_C-RD
SelR PMSR
SelR
TCTP TCTP

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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