Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1525  structures 27803  species 139  interactions 676016  sequences 11641  architectures

Clan: Beta_propeller (CL0186)

Summary

Beta propeller clan Add an annotation

This large clan contains proteins that contain beta propellers. These are composed of between 6 and 8 repeats. The individual repeats are composed of a four stranded sheet. The clan includes families such as WD40 Pfam:PF00400 where the individual repeats are modeled. The clan also includes families where the entire propeller is modeled such as Pfam:PF02239 usually because the individual repeats are not discernible. These proteins carry out a very wide diversity of functions including catalysis.

This clan contains 67 families and the total number of domains in the clan is 676016. The clan was built by A Bateman.

Literature references

  1. Murzin AG; , Proteins. 1992;14:191-201.: Structural principles for the propeller assembly of beta-sheets: the preference for seven-fold symmetry. PUBMED:1409568 EPMC:1409568

Members

This clan contains the following 67 member families:

ANAPC4_WD40 Arylesterase Arylsulfotran_2 Arylsulfotrans BBS2_Mid Beta_propel Coatomer_WDAD CPSF_A Cytochrom_D1 DPPIV_N DUF1513 DUF1668 DUF2415 DUF3312 DUF4221 DUF5050 DUF839 eIF2A FG-GAP FG-GAP_2 Ge1_WD40 Glu_cyclase_2 Gmad1 GSDH IKI3 Itfg2 Kelch_1 Kelch_2 Kelch_3 Kelch_4 Kelch_5 Kelch_6 Lactonase Ldl_recept_b Lgl_C LVIVD Me-amine-dh_H MRJP Nbas_N Neisseria_PilC NHL Nucleoporin_N Nup160 PALB2_WD40 PD40 Pectate_lyase22 Peptidase_S9_N Phytase-like PQQ PQQ_2 PQQ_3 RAG2 RCC1 RCC1_2 Reg_prop SBBP SBP56 SdiA-regulated SGL Str_synth TcdB_toxin_midN TolB_like VCBS WD40 WD40_3 WD40_4 WD40_like

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
WD40 (PF00400) 255261 (37.8%) View
PD40 (PF07676) 52601 (7.8%) View
Kelch_1 (PF01344) 34933 (5.2%) View
PQQ_2 (PF13360) 31427 (4.6%) View
RCC1 (PF00415) 30103 (4.5%) View
NHL (PF01436) 25136 (3.7%) View
PQQ (PF01011) 17257 (2.6%) View
Lactonase (PF10282) 17229 (2.5%) View
Reg_prop (PF07494) 16664 (2.5%) View
GSDH (PF07995) 14422 (2.1%) View
VCBS (PF13517) 13922 (2.1%) View
SGL (PF08450) 13695 (2.0%) View
Cytochrom_D1 (PF02239) 12769 (1.9%) View
Peptidase_S9_N (PF02897) 11890 (1.8%) View
Ldl_recept_b (PF00058) 11663 (1.7%) View
RAG2 (PF03089) 7725 (1.1%) View
Kelch_3 (PF13415) 7032 (1.0%) View
DUF839 (PF05787) 6944 (1.0%) View
SBBP (PF06739) 6813 (1.0%) View
Kelch_4 (PF13418) 6750 (1.0%) View
RCC1_2 (PF13540) 6539 (1.0%) View
FG-GAP (PF01839) 6204 (0.9%) View
Arylsulfotrans (PF05935) 5431 (0.8%) View
SdiA-regulated (PF06977) 5220 (0.8%) View
DPPIV_N (PF00930) 4371 (0.6%) View
Phytase-like (PF13449) 4337 (0.6%) View
PQQ_3 (PF13570) 4088 (0.6%) View
LVIVD (PF08309) 3711 (0.5%) View
Kelch_6 (PF13964) 3453 (0.5%) View
eIF2A (PF08662) 2626 (0.4%) View
Kelch_5 (PF13854) 2545 (0.4%) View
Gmad1 (PF10647) 2345 (0.3%) View
CPSF_A (PF03178) 2185 (0.3%) View
FG-GAP_2 (PF14312) 2180 (0.3%) View
continued
Pfam family Num. domains Alignment
Neisseria_PilC (PF05567) 2066 (0.3%) View
Str_synth (PF03088) 1951 (0.3%) View
Coatomer_WDAD (PF04053) 1741 (0.3%) View
MRJP (PF03022) 1579 (0.2%) View
Arylsulfotran_2 (PF14269) 1524 (0.2%) View
WD40_4 (PF16300) 1495 (0.2%) View
TolB_like (PF15869) 1448 (0.2%) View
Kelch_2 (PF07646) 1399 (0.2%) View
Glu_cyclase_2 (PF05096) 1180 (0.2%) View
Nucleoporin_N (PF08801) 1066 (0.2%) View
DUF1513 (PF07433) 1061 (0.2%) View
Nup160 (PF11715) 983 (0.1%) View
IKI3 (PF04762) 893 (0.1%) View
DUF1668 (PF07893) 863 (0.1%) View
Pectate_lyase22 (PF14583) 818 (0.1%) View
SBP56 (PF05694) 770 (0.1%) View
TcdB_toxin_midN (PF12256) 752 (0.1%) View
DUF5050 (PF16472) 727 (0.1%) View
Lgl_C (PF08596) 558 (0.1%) View
ANAPC4_WD40 (PF12894) 532 (0.1%) View
Arylesterase (PF01731) 454 (0.1%) View
DUF4221 (PF13970) 436 (0.1%) View
Beta_propel (PF09826) 383 (0.1%) View
DUF2415 (PF10313) 321 (0.0%) View
Ge1_WD40 (PF16529) 313 (0.0%) View
Itfg2 (PF15907) 258 (0.0%) View
WD40_3 (PF15911) 211 (0.0%) View
BBS2_Mid (PF14783) 200 (0.0%) View
Me-amine-dh_H (PF06433) 172 (0.0%) View
DUF3312 (PF11768) 150 (0.0%) View
Nbas_N (PF15492) 121 (0.0%) View
PALB2_WD40 (PF16756) 83 (0.0%) View
WD40_like (PF17005) 37 (0.0%) View
Total: 67 Total: 676016 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 139 interactions for this clan. More...

Interacting families
A B
Actin WD40
Arylsulfotrans Arylsulfotrans
Beta-lactamase2 RCC1_2
CAF1C_H4-bd WD40
Coatomer_WDAD Coatomer_WDAD
COPI_C
Copper-bind Me-amine-dh_H
CPSF_A Cullin
Soyouz_module
WD40
X
zf-Paramyx-P
Cytochrom_D1 Cytochrom_D1
Cytochrome_CBB3 Cytochrom_D1
DEP WD40
DPPIV_N A_deaminase
Cloacin
DPPIV_N
Hormone_3
OmpA
PD40
Peptidase_S9
Spike_rec_bind
TolB_N
DUF1899 WD40
FATC WD40
FG-GAP FG-GAP
Integrin_alpha2
Integrin_beta
G-alpha WD40
G-gamma WD40
Glu_cyclase_2 Glu_cyclase_2
GSDH GSDH
HH_signal
HH_signal GSDH
Inhibitor_I9 Ldl_recept_b
IRK WD40
Kelch_1 DUF1929
Kelch_1
Prothymosin
Lactonase Lactonase
PKD
Laminin_G_1 Ldl_recept_b
Ldl_recept_a Ldl_recept_b
Ldl_recept_b FXa_inhibition
Laminin_EGF
Laminin_G_1
Ldl_recept_b
Sclerostin
Lipase_GDSL_2 WD40
Me-amine-dh_H Copper-bind
Me-amine-dh_H
Me-amine-dh_L
Me-amine-dh_L Me-amine-dh_H
MMS1_N CPSF_A
WD40
MRJP MRJP
NB-ARC WD40
Neisseria_PilC Neisseria_PilC
NHL NHL
Nucleopor_Nup85 WD40
Nup160 Nup160
Nup96 WD40
PD40 Cloacin
DPPIV_N
OmpA
PD40
Peptidase_S41
TolB_N
Tricorn_PDZ
Pectate_lyase22 Pectate_lyase22
Peptidase_S41 PD40
Peptidase_S9 DPPIV_N
Peptidase_S9_N Peptidase_S9
Peptidase_S9_N
PH WD40
PI3_PI4_kinase WD40
PKD Lactonase
PQQ Cytochrome_CBB3
MDH
PQQ
PQQ_2
PQQ_2 Cytochrome_CBB3
PQQ
PQQ_2
PQQ_3
PQQ_3 PQQ_2
PRMT5 WD40
Ras RCC1
RCC1 Ras
RCC1
RCC1_2 RCC1_2
Reg_prop Reg_prop
Y_Y_Y
RGS WD40
Ribosomal_S17e WD40
Ribosomal_S2 WD40
Ribosomal_S4e WD40
Ribosomal_S6e WD40
Ribosomal_S9 WD40
Sec16 WD40
Sec16_C WD40
SGL SGL
SpvB TcdB_toxin_midN
TcdB_toxin_midN TcdB_toxin_midC
TolB_N DPPIV_N
PD40
Tricorn_PDZ PD40
VCBS VCBS
WD40 7tm_1
ARPC4
CAF1C_H4-bd
Coatomer_WDAD
Cofilin_ADF
Cytochrom_C
EZH2_WD-Binding
G-gamma
Histone
HORMA
Lipase_GDSL_2
Mad3_BUB1_II
Methyltransf_4
MMS1_N
N-SET
Nucleopor_Nup85
Nup96
P16-Arc
Phosducin
Ribosomal_S17e
Ribosomal_S2
Ribosomal_S5
Ribosomal_S8
Ribosomal_S9
SBP_bac_1
Sec16
Sec16_C
Trimer_CC
WD40
Y_Y_Y Reg_prop

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...