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62  structures 1089  species 6  interactions 35516  sequences 1487  architectures

Clan: C1 (CL0006)


Protein kinase C, C1 domain Add an annotation

The members of this clan are all variations of the protein kinase C1 domain that is characterised by a rich cysteine and histidine content. The C1 domain is the N-terminal region of conservation found in protein kinase C domains. This domain is involved in binding many ligands, which include diacylglycerol, phorbol esters and zinc [1].

This clan contains 4 families and the total number of domains in the clan is 35516. The clan was built by RD Finn.

Literature references

  1. Azzi A, Boscoboinik D, Hensey C; , Eur J Biochem 1992;208:547-557.: The protein kinase C family. PUBMED:1396661 EPMC:1396661


This clan contains the following 4 member families:

C1_1 C1_2 C1_4 ZZ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
C1_1 (PF00130) 17396 (49.0%) View
ZZ (PF00569) 9130 (25.7%) View
C1_2 (PF03107) 8150 (22.9%) View
C1_4 (PF07975) 840 (2.4%) View
Total: 4 Total: 35516 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 6 interactions for this clan. More...

Interacting families
C1_1 Pkinase
PH C1_1
RhoGEF C1_1
SH2 C1_1


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...