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222  structures 571  species 7  interactions 27805  sequences 791  architectures

Clan: C2 (CL0154)


C2 superfamily Add an annotation

This superfamily includes C2 domains and C2-like domains.

This clan contains 9 families and the total number of domains in the clan is 27805. The clan was built by A Bateman.

Literature references

  1. Ponting CP, Parker PJ; , Protein Sci 1996;5:162-166.: Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin. PUBMED:8771209 EPMC:8771209
  2. Zhang D, Aravind L;, Gene. 2010;469:18-30.: Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. PUBMED:20713135 EPMC:20713135


This clan contains the following 9 member families:

Aida_C2 B9-C2 C2 CC2D2AN-C2 CEP76-C2 DOCK-C2 NT-C2 PI3K_C2 PTEN_C2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
C2 (PF00168) 23398 (84.2%) View
DOCK-C2 (PF14429) 1118 (4.0%) View
PI3K_C2 (PF00792) 929 (3.3%) View
PTEN_C2 (PF10409) 847 (3.0%) View
NT-C2 (PF10358) 744 (2.7%) View
B9-C2 (PF07162) 444 (1.6%) View
CC2D2AN-C2 (PF15625) 138 (0.5%) View
Aida_C2 (PF14186) 105 (0.4%) View
CEP76-C2 (PF15627) 82 (0.3%) View
Total: 9 Total: 27805 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 7 interactions for this clan. More...

Interacting families
PI3K_C2 PI3_PI4_kinase
C2 C2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...