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421  structures 1400  species 25  interactions 65835  sequences 1921  architectures

Clan: C2 (CL0154)

Summary

C2 superfamily Add an annotation

This superfamily includes C2 domains and C2-like domains.

This clan contains 15 families and the total number of domains in the clan is 65835. The clan was built by A Bateman.

Literature references

  1. Ponting CP, Parker PJ; , Protein Sci 1996;5:162-166.: Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin. PUBMED:8771209 EPMC:8771209
  2. Zhang D, Aravind L;, Gene. 2010;469:18-30.: Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. PUBMED:20713135 EPMC:20713135

Members

This clan contains the following 15 member families:

Aida_C2 Anillin B9-C2 C2 C2-C2_1 CC2D2AN-C2 CEP76-C2 DOCK-C2 IcmF_C MNNL NT-C2 PI3K_C2 PTEN_C2 Spond_N YEATS

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
C2 (PF00168) 51668 (78.5%) View
DOCK-C2 (PF14429) 2282 (3.5%) View
NT-C2 (PF10358) 1894 (2.9%) View
YEATS (PF03366) 1821 (2.8%) View
PTEN_C2 (PF10409) 1783 (2.7%) View
PI3K_C2 (PF00792) 1745 (2.7%) View
B9-C2 (PF07162) 871 (1.3%) View
Anillin (PF08174) 843 (1.3%) View
Spond_N (PF06468) 746 (1.1%) View
IcmF_C (PF06744) 729 (1.1%) View
MNNL (PF07657) 489 (0.7%) View
C2-C2_1 (PF11618) 324 (0.5%) View
CC2D2AN-C2 (PF15625) 298 (0.5%) View
Aida_C2 (PF14186) 183 (0.3%) View
CEP76-C2 (PF15627) 159 (0.2%) View
Total: 15 Total: 65835 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 25 interactions for this clan. More...

Interacting families
A B
Aida_C2 Aida_C2
C2 C2
EF-hand_like
FGF
FYVE_2
PI-PLC-X
PI-PLC-Y
PLA2_B
S_100
DOCK-C2 DOCK-C2
DSPc PTEN_C2
EF-hand_10 C2
EF-hand_like C2
FGF C2
Ion_trans PTEN_C2
PI-PLC-X C2
PI-PLC-Y C2
PI3K_C2 PI3_PI4_kinase
PI3Ka
SH2
PTEN_C2 PTEN_C2
S_100 C2
SH2 C2
Spond_N Spond_N
YEATS YEATS

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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