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352  structures 1352  species 16  interactions 420550  sequences 8541  architectures

Clan: C2H2-zf (CL0361)

Summary

Classical C2H2 and C2HC zinc fingers Add an annotation

Superfamily of classical and closely related C2H2 or beta-beta-alpha zinc finger DNA-binding domains.

This clan contains 37 families and the total number of domains in the clan is 420550. The clan was built by P Coggill.

Members

This clan contains the following 37 member families:

4F5 ARS2 DUF3449 GAGA Hat1_N Nairovirus_M ROS_MUCR Sgf11 UBZ_FAAP20 zf-AD zf-BED zf-C2H2 zf-C2H2_10 zf-C2H2_11 zf-C2H2_2 zf-C2H2_3 zf-C2H2_4 zf-C2H2_6 zf-C2H2_7 zf-C2H2_8 zf-C2H2_9 zf-C2H2_aberr zf-C2H2_jaz zf-C2HC_2 zf-C2HE zf-DBF zf-Di19 zf-H2C2 zf-H2C2_2 zf-H2C2_5 zf-H3C2 zf-LYAR zf-met zf-met2 zf-RAG1 zf-U1 zf-U11-48K

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-C2H2 (PF00096) 340711 (81.0%) View
zf-C2H2_6 (PF13912) 20575 (4.9%) View
zf-met (PF12874) 14429 (3.4%) View
zf-C2H2_4 (PF13894) 6858 (1.6%) View
zf-H2C2_5 (PF13909) 6023 (1.4%) View
zf-C2H2_jaz (PF12171) 5205 (1.2%) View
zf-AD (PF07776) 3027 (0.7%) View
zf-BED (PF02892) 2780 (0.7%) View
zf-C2HC_2 (PF13913) 2147 (0.5%) View
zf-C2H2_2 (PF12756) 1986 (0.5%) View
zf-H2C2_2 (PF13465) 1745 (0.4%) View
zf-U1 (PF06220) 1645 (0.4%) View
zf-Di19 (PF05605) 1482 (0.4%) View
4F5 (PF04419) 1224 (0.3%) View
zf-U11-48K (PF05253) 1121 (0.3%) View
ROS_MUCR (PF05443) 1074 (0.3%) View
zf-H2C2 (PF09337) 1036 (0.2%) View
DUF3449 (PF11931) 845 (0.2%) View
zf-C2H2_3 (PF13878) 818 (0.2%) View
continued
Pfam family Num. domains Alignment
ARS2 (PF04959) 802 (0.2%) View
zf-C2H2_11 (PF16622) 768 (0.2%) View
Hat1_N (PF10394) 767 (0.2%) View
zf-LYAR (PF08790) 708 (0.2%) View
zf-DBF (PF07535) 667 (0.2%) View
zf-C2HE (PF16278) 576 (0.1%) View
Sgf11 (PF08209) 514 (0.1%) View
zf-met2 (PF12907) 496 (0.1%) View
zf-C2H2_7 (PF15269) 145 (0.0%) View
GAGA (PF09237) 100 (0.0%) View
zf-RAG1 (PF10426) 69 (0.0%) View
zf-C2H2_8 (PF15909) 66 (0.0%) View
zf-C2H2_aberr (PF17017) 48 (0.0%) View
zf-C2H2_10 (PF16588) 46 (0.0%) View
UBZ_FAAP20 (PF15750) 34 (0.0%) View
zf-C2H2_9 (PF16293) 9 (0.0%) View
Nairovirus_M (PF07948) 2 (0.0%) View
zf-H3C2 (PF16721) 2 (0.0%) View
Total: 37 Total: 420550 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 16 interactions for this clan. More...

Interacting families
A B
DUF3449 PRP21_like_P
DUF3546 ARS2
GATA zf-C2H2_6
Hat1_N Acetyltransf_10
Pkinase zf-DBF
UCH Sgf11
zf-C2H2 zf-C2H2
zf-C2H2_4
zf-C2H2_2 zf-C2H2_2
zf-C2H2_4 zf-C2H2_4
zf-C2H2_6 zf-H2C2_2
zf-C2H2_jaz DUF3449
zf-C3HC4 zf-RAG1
zf-H2C2_2 zf-C2H2
zf-H2C2_2
zf-H2C2_5 zf-H2C2_5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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