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429  structures 1185  species 12  interactions 8803  sequences 259  architectures

Clan: CDC (CL0293)


Cholesterol-dependent cytolysin superfamily Add an annotation

This superfamily includes the MACPF domain as well as the Cholesterol-dependent cytolysins [1].

This clan contains 8 families and the total number of domains in the clan is 8803. The clan was built by A Bateman.

Literature references

  1. Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani , Science. 2007;317:1548-1551.: A common fold mediates vertebrate defense and bacterial attack. PUBMED:17717151 EPMC:17717151


This clan contains the following 8 member families:

Aegerolysin Anemone_cytotox FB_lectin Gasdermin MACPF TDH Thaumatin Thiol_cytolysin

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Thaumatin (PF00314) 4052 (46.0%) View
MACPF (PF01823) 3445 (39.1%) View
Gasdermin (PF04598) 574 (6.5%) View
Aegerolysin (PF06355) 260 (3.0%) View
Thiol_cytolysin (PF01289) 251 (2.9%) View
FB_lectin (PF07367) 140 (1.6%) View
Anemone_cytotox (PF06369) 79 (0.9%) View
TDH (PF03347) 2 (0.0%) View
Total: 8 Total: 8803 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 12 interactions for this clan. More...

Interacting families
Anemone_cytotox Anemone_cytotox
FB_lectin FB_lectin
Ldl_recept_a MACPF
MACPF Ldl_recept_a
TED_complement MACPF
Thaumatin Thaumatin
Thiol_cytolysin Thiol_cytolysin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...