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28  structures 1848  species 9  interactions 4493  sequences 104  architectures

Clan: CDC (CL0293)

Summary

Cholesterol-dependent cytolysin superfamily Add an annotation

This superfamily includes the MACPF domain as well as the Cholesterol-dependent cytolysins [1].

This clan contains 3 families and the total number of domains in the clan is 4493. The clan was built by A Bateman.

Literature references

  1. Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani , Science. 2007;317:1548-1551.: A common fold mediates vertebrate defense and bacterial attack. PUBMED:17717151 EPMC:17717151

Members

This clan contains the following 3 member families:

Aegerolysin MACPF Thiol_cytolysin

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MACPF (PF01823) 2325 (51.7%) View
Thiol_cytolysin (PF01289) 1814 (40.4%) View
Aegerolysin (PF06355) 354 (7.9%) View
Total: 3 Total: 4493 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 9 interactions for this clan. More...

Interacting families
A B
A2M_comp MACPF
Ldl_recept_a MACPF
MACPF Ldl_recept_a
Lipocalin
MACPF
TSP_1
Thiol_cytolysin Thiol_cytolysin
UPAR_LY6
TSP_1 MACPF

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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