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58  structures 353  species 4  interactions 2801  sequences 39  architectures

Clan: CHCH (CL0351)


Coiled-coil helix coiled-coil helix superfamily Add an annotation

The conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain) superfamily members include NADH-ubiquinone oxidoreductases, some cytochrome oxidases and yeast mitochondrial ribosomal proteins. Within each helix of the CHCH domain there are two cysteines present in a C-X9-C motif.

This clan contains 6 families and the total number of domains in the clan is 2801. The clan was built by A Bateman.


This clan contains the following 6 member families:

CHCH Cmc1 COX6B DUF1903 NDUF_B7 Ndufs5

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CHCH (PF06747) 994 (35.5%) View
COX6B (PF02297) 675 (24.1%) View
Cmc1 (PF08583) 511 (18.2%) View
NDUF_B7 (PF05676) 256 (9.1%) View
DUF1903 (PF08991) 194 (6.9%) View
Ndufs5 (PF10200) 171 (6.1%) View
Total: 6 Total: 2801 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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