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67  structures 1740  species 3  interactions 2530  sequences 9  architectures

Clan: CI-2 (CL0367)


CI-2 family of serine protease inhibitors Add an annotation

This superfamily includes a range of universally found subtilases, that are serine proteases.

This clan contains 2 families and the total number of domains in the clan is 2530. The clan was built by A Bateman.


This clan contains the following 2 member families:

Inhibitor_I78 potato_inhibit

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Inhibitor_I78 (PF11720) 1752 (69.2%) View
potato_inhibit (PF00280) 778 (30.8%) View
Total: 2 Total: 2530 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
Peptidase_S8 potato_inhibit
potato_inhibit potato_inhibit
Trypsin potato_inhibit


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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