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912  structures 490  species 79  interactions 182627  sequences 10479  architectures

Clan: EGF (CL0001)

Summary

EGF superfamily Add an annotation

Members of this clan all belong to the EGF superfamily. This particular superfamily is characterised as having least 6 cysteine residues. These cysteines form disulphide bonds, in the order 1-3, 2-4, 5-6, which are essential for the stability of the EGF fold. These disulphide bonds are stacked in a ladder-like arrangement. The Laminin EGF family is distinguished by having an an additional disulphide bond. The function of the domains within this family remains unclear, but they are thought to largely perform a structural role. More often than not, these domains are arranged in tandem repeats in extracellular proteins.

This clan contains 18 families and the total number of domains in the clan is 182627. The clan was built by RD Finn and A Bateman.

Literature references

  1. Appella E, Weber IT, Blasi F; , FEBS Lett 1988;231:1-4.: Structure and function of epidermal growth factor-like regions in proteins. PUBMED:3282918 EPMC:3282918
  2. Hohenester E, Engel J; , Matrix Biol 2002;21:115-128.: Domain structure and organisation in extracellular matrix proteins. PUBMED:11852228 EPMC:11852228

Members

This clan contains the following 18 member families:

cEGF CFC DSL EGF EGF_2 EGF_3 EGF_alliinase EGF_CA EGF_MSP1_1 FOLN FXa_inhibition Gla hEGF Laminin_EGF Plasmod_Pvs28 Sushi Sushi_2 Tme5_EGF_like

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EGF_CA (PF07645) 43415 (23.8%) View
EGF (PF00008) 41563 (22.8%) View
Sushi (PF00084) 32437 (17.8%) View
Laminin_EGF (PF00053) 31797 (17.4%) View
hEGF (PF12661) 9095 (5.0%) View
FXa_inhibition (PF14670) 8990 (4.9%) View
cEGF (PF12662) 4456 (2.4%) View
EGF_2 (PF07974) 3981 (2.2%) View
EGF_3 (PF12947) 3734 (2.0%) View
Gla (PF00594) 1107 (0.6%) View
DSL (PF01414) 917 (0.5%) View
FOLN (PF09289) 510 (0.3%) View
CFC (PF09443) 139 (0.1%) View
Sushi_2 (PF09014) 130 (0.1%) View
Plasmod_Pvs28 (PF06247) 122 (0.1%) View
EGF_alliinase (PF04863) 122 (0.1%) View
Tme5_EGF_like (PF09064) 64 (0.0%) View
EGF_MSP1_1 (PF12946) 48 (0.0%) View
Total: 18 Total: 182627 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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