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1303  structures 20323  species 21  interactions 247272  sequences 444  architectures

Clan: Beta-lactamase (CL0013)

Summary

Serine beta-lactamase-like superfamily Add an annotation

This superfamily contains proteins that have a beta-lactamase fold. This includes beta-lactamases as well as Dala-Dala carboxypeptidases and glutaminases.

This clan contains 6 families and the total number of domains in the clan is 247272. The clan was built by RD Finn and A Bateman.

Members

This clan contains the following 6 member families:

Beta-lactamase Beta-lactamase2 Glutaminase Peptidase_S11 Peptidase_S13 Transpeptidase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Transpeptidase (PF00905) 102112 (41.3%) View
Beta-lactamase (PF00144) 65816 (26.6%) View
Peptidase_S11 (PF00768) 39497 (16.0%) View
Beta-lactamase2 (PF13354) 18236 (7.4%) View
Peptidase_S13 (PF02113) 11527 (4.7%) View
Glutaminase (PF04960) 10084 (4.1%) View
Total: 6 Total: 247272 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 21 interactions for this clan. More...

Interacting families
A B
Beta-lactamase Beta-lactamase
DAP_B
Pab87_oct
Beta-lactamase2 Beta-lactamase2
BLIP
RCC1_2
Glutaminase Glutaminase
Pab87_oct Beta-lactamase
PBP5_C Peptidase_S11
PBP_dimer Transpeptidase
Peptidase_S11 DUF1958
PBP5_C
Peptidase_S11
Peptidase_S13 Peptidase_S13
SBP_bac_1 Beta-lactamase2
Transgly Transpeptidase
Transpeptidase PASTA
PBP_dimer
Transgly
Transpeptidase
UB2H Transpeptidase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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