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76  structures 21522  species 4  interactions 1071358  sequences 1430  architectures

Clan: MFS (CL0015)

Summary

Major Facilitator Superfamily Add an annotation

The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth [1]. It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity [1]. All permeases of the MFS possess either 12 or 14 transmembrane helices [1].

This clan contains 24 families and the total number of domains in the clan is 1071358. The clan was built by A Bateman.

Literature references

  1. Pao SS, Paulsen IT, Saier MH Jr; , Microbiol Mol Biol Rev 1998;62:1-34.: Major facilitator superfamily. PUBMED:9529885 EPMC:9529885

Members

This clan contains the following 24 member families:

Acatn ATG22 BT1 Folate_carrier FPN1 FTR1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_4 MFS_5 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MFS_1 (PF07690) 838004 (78.2%) View
Sugar_tr (PF00083) 100431 (9.4%) View
PTR2 (PF00854) 31086 (2.9%) View
MFS_2 (PF13347) 26615 (2.5%) View
MFS_3 (PF05977) 19738 (1.8%) View
FTR1 (PF03239) 11503 (1.1%) View
Nuc_H_symport (PF03825) 10080 (0.9%) View
LacY_symp (PF01306) 7479 (0.7%) View
MFS_4 (PF06779) 5964 (0.6%) View
ATG22 (PF11700) 4791 (0.4%) View
BT1 (PF03092) 2376 (0.2%) View
OATP (PF03137) 1964 (0.2%) View
MFS_1_like (PF12832) 1906 (0.2%) View
continued
Pfam family Num. domains Alignment
Nucleoside_tran (PF01733) 1850 (0.2%) View
Nodulin-like (PF06813) 1205 (0.1%) View
UNC-93 (PF05978) 1116 (0.1%) View
TLC (PF03219) 1015 (0.1%) View
Acatn (PF13000) 1014 (0.1%) View
FPN1 (PF06963) 757 (0.1%) View
TRI12 (PF06609) 706 (0.1%) View
Folate_carrier (PF01770) 611 (0.1%) View
MFS_5 (PF05631) 578 (0.1%) View
PUCC (PF03209) 470 (0.0%) View
MFS_Mycoplasma (PF07672) 99 (0.0%) View
Total: 24 Total: 1071358 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
LacY_symp LacY_symp
MFS_1 MFS_1
MHC_I OATP
PTR2 PTR2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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