Summary
Protein kinase superfamily
This superfamily includes the Serine/Threonine- and Tyrosine- protein kinases as well as related kinases that act on non-protein substrates.
This clan contains 40 families and the total number of domains in the clan is 930239. The clan was built by DJ Studholme.
Literature references
- Hanks SK, Quinn AM; , Methods Enzymol 1991;200:38-62.: Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. PUBMED:1956325 EPMC:1956325
- Hanks SK, Hunter T; , FASEB J 1995;9:576-596.: Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. PUBMED:7768349 EPMC:7768349
- Hunter T, Plowman GD; , Trends Biochem Sci 1997;22:18-22.: The protein kinases of budding yeast: six score and more. PUBMED:9020587 EPMC:9020587
Members
This clan contains the following 40 member families:
ABC1 AceK Act-Frag_cataly Alpha_kinase APH APH_6_hur Choline_kinase CotH DUF1679 DUF2252 DUF4135 DUF5898 EcKL Fam20C Fructosamin_kin FTA2 Haspin_kinase HipA_C Ins_P5_2-kin IPK IucA_IucC Kdo Kinase-like Kinase-PolyVal KIND Pan3_PK PI3_PI4_kinase PIP49_C PIP5K PK_Tyr_Ser-Thr Pkinase Pkinase_fungal Pox_ser-thr_kin RIO1 Seadorna_VP7 TCAD9 UL97 WaaY YrbL-PhoP_reg YukCDomain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
| Pfam family | Num. domains | Alignment |
|---|---|---|
| Pkinase (PF00069) | 558654 (60.1%) | View |
| PK_Tyr_Ser-Thr (PF07714) | 187300 (20.1%) | View |
| APH (PF01636) | 50139 (5.4%) | View |
| PI3_PI4_kinase (PF00454) | 23731 (2.6%) | View |
| ABC1 (PF03109) | 21286 (2.3%) | View |
| PIP5K (PF01504) | 13770 (1.5%) | View |
| Pkinase_fungal (PF17667) | 10423 (1.1%) | View |
| RIO1 (PF01163) | 6509 (0.7%) | View |
| Choline_kinase (PF01633) | 6105 (0.7%) | View |
| IPK (PF03770) | 5142 (0.6%) | View |
| Fructosamin_kin (PF03881) | 4800 (0.5%) | View |
| HipA_C (PF07804) | 4794 (0.5%) | View |
| EcKL (PF02958) | 4221 (0.5%) | View |
| Kdo (PF06293) | 4188 (0.5%) | View |
| Alpha_kinase (PF02816) | 3855 (0.4%) | View |
| CotH (PF08757) | 3427 (0.4%) | View |
| IucA_IucC (PF04183) | 3250 (0.3%) | View |
| DUF2252 (PF10009) | 2498 (0.3%) | View |
| PIP49_C (PF12260) | 2015 (0.2%) | View |
| Ins_P5_2-kin (PF06090) | 1901 (0.2%) | View |
| APH_6_hur (PF04655) | 1894 (0.2%) | View |
| continued | ||
| Pfam family | Num. domains | Alignment |
|---|---|---|
| Pan3_PK (PF18101) | 1613 (0.2%) | View |
| Fam20C (PF06702) | 1605 (0.2%) | View |
| Haspin_kinase (PF12330) | 1407 (0.2%) | View |
| KIND (PF16474) | 1406 (0.2%) | View |
| DUF1679 (PF07914) | 935 (0.1%) | View |
| AceK (PF06315) | 787 (0.1%) | View |
| DUF4135 (PF13575) | 730 (0.1%) | View |
| Act-Frag_cataly (PF09192) | 436 (0.0%) | View |
| FTA2 (PF13095) | 371 (0.0%) | View |
| YrbL-PhoP_reg (PF10707) | 285 (0.0%) | View |
| YukC (PF10140) | 195 (0.0%) | View |
| Kinase-like (PF14531) | 138 (0.0%) | View |
| WaaY (PF06176) | 112 (0.0%) | View |
| Kinase-PolyVal (PF18762) | 103 (0.0%) | View |
| TCAD9 (PF19974) | 81 (0.0%) | View |
| Pox_ser-thr_kin (PF05445) | 50 (0.0%) | View |
| DUF5898 (PF19250) | 45 (0.0%) | View |
| UL97 (PF06734) | 27 (0.0%) | View |
| Seadorna_VP7 (PF07387) | 11 (0.0%) | View |
| Total: 40 | Total: 930239 |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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