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7190  structures 80351  species 553  interactions 5072865  sequences 17426  architectures

Clan: P-loop_NTPase (CL0023)

Summary

P-loop containing nucleoside triphosphate hydrolase superfamily Add an annotation

AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].

This clan contains 198 families and the total number of domains in the clan is 5072865. The clan was built by DJ Studholme.

Literature references

  1. Confalonieri F, Duguet M; , Bioessays 1995;17:639-650.: A 200-amino acid ATPase module in search of a basic function. PUBMED:7646486 EPMC:7646486
  2. Neuwald AF, Aravind L, Spouge JL, Koonin EV; , Genome Res 1999;9:27-43.: AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. PUBMED:9927482 EPMC:9927482
  3. Leipe DD, Wolf YI, Koonin EV, Aravind L;, J Mol Biol. 2002;317:41-72.: Classification and evolution of P-loop GTPases and related ATPases. PUBMED:11916378 EPMC:11916378
  4. Leipe DD, Koonin EV, Aravind L;, J Mol Biol. 2004;343:1-28.: STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer. PUBMED:15381417 EPMC:15381417
  5. Leipe DD, Koonin EV, Aravind L;, J Mol Biol. 2003;333:781-815.: Evolution and classification of P-loop kinases and related proteins. PUBMED:14568537 EPMC:14568537

Members

This clan contains the following 198 member families:

6PF2K AAA AAA-ATPase_like AAA_10 AAA_11 AAA_12 AAA_13 AAA_14 AAA_15 AAA_16 AAA_17 AAA_18 AAA_19 AAA_2 AAA_21 AAA_22 AAA_23 AAA_24 AAA_25 AAA_26 AAA_27 AAA_28 AAA_29 AAA_3 AAA_30 AAA_31 AAA_32 AAA_33 AAA_34 AAA_35 AAA_5 AAA_6 AAA_7 AAA_8 AAA_PrkA ABC_ATPase ABC_tran Adeno_IVa2 Adenylsucc_synt ADK AFG1_ATPase AIG1 APS_kinase Arch_ATPase Arf ArgK ArsA_ATPase ATP-synt_ab ATP_bind_1 ATP_bind_2 Bac_DnaA CbiA CBP_BcsQ CDC73_C CLP1_P CMS1 CoaE CobA_CobO_BtuR CobU cobW CPT CTP_synth_N Cytidylate_kin Cytidylate_kin2 DAP3 DEAD DEAD_2 DLIC DNA_pack_C DNA_pack_N DNA_pol3_delta DNA_pol3_delta2 DnaB_C dNK DUF1611 DUF2075 DUF2478 DUF258 DUF2791 DUF2813 DUF3584 DUF463 DUF815 DUF853 DUF87 DUF927 Dynamin_N ERCC3_RAD25_C Exonuc_V_gamma FeoB_N Fer4_NifH Flavi_DEAD FTHFS FtsK_SpoIIIE G-alpha Gal-3-0_sulfotr GBP GTP_EFTU Gtr1_RagA Guanylate_kin GvpD HDA2-3 Helicase_C Helicase_C_2 Helicase_C_4 Helicase_RecD Herpes_Helicase Herpes_ori_bp Herpes_TK IIGP IPPT IPT IstB_IS21 KaiC KAP_NTPase KdpD Kinesin Kinesin-relat_1 Kinesin-related KTI12 Lon_2 LpxK MCM MEDS Mg_chelatase Microtub_bd MipZ MMR_HSR1 MobB MukB MutS_V Myosin_head NACHT NB-ARC NOG1 NTPase_1 NTPase_P4 ParA Parvo_NS1 PAXNEB PduV-EutP PhoH PIF1 Podovirus_Gp16 Polyoma_lg_T_C Pox_A32 PPK2 PPV_E1_C PRK Rad17 Rad51 Ras RecA ResIII RHD3 RHSP RNA12 RNA_helicase Roc RuvB_N SbcCD_C SecA_DEAD Septin Sigma54_activ_2 Sigma54_activat SKI SMC_N SNF2_N Spore_IV_A SRP54 SRPRB Sulfotransfer_1 Sulfotransfer_2 Sulfotransfer_3 Sulphotransf T2SSE T4SS-DNA_transf Terminase_1 Terminase_3 Terminase_6 Terminase_GpA Thymidylate_kin TIP49 TK TniB Torsin TraG-D_C tRNA_lig_kinase TrwB_AAD_bind TsaE UvrD-helicase UvrD_C UvrD_C_2 Viral_helicase1 VirC1 VirE Zeta_toxin Zot

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ABC_tran (PF00005) 1466247 (28.9%) View
Helicase_C (PF00271) 299814 (5.9%) View
DEAD (PF00270) 200180 (3.9%) View
GTP_EFTU (PF00009) 189450 (3.7%) View
MMR_HSR1 (PF01926) 181801 (3.6%) View
AAA (PF00004) 177485 (3.5%) View
ATP-synt_ab (PF00006) 94948 (1.9%) View
Sigma54_activat (PF00158) 90640 (1.8%) View
AAA_2 (PF07724) 88630 (1.7%) View
ResIII (PF04851) 85706 (1.7%) View
UvrD_C (PF13361) 74056 (1.5%) View
UvrD-helicase (PF00580) 72337 (1.4%) View
FtsK_SpoIIIE (PF01580) 68657 (1.4%) View
CbiA (PF01656) 68109 (1.3%) View
SMC_N (PF02463) 57444 (1.1%) View
cobW (PF02492) 53961 (1.1%) View
T2SSE (PF00437) 47376 (0.9%) View
SRP54 (PF00448) 43389 (0.9%) View
SNF2_N (PF00176) 39744 (0.8%) View
DNA_pol3_delta2 (PF13177) 38989 (0.8%) View
Ras (PF00071) 37595 (0.7%) View
MutS_V (PF00488) 37532 (0.7%) View
AAA_5 (PF07728) 35347 (0.7%) View
IstB_IS21 (PF01695) 34555 (0.7%) View
AAA_31 (PF13614) 32766 (0.6%) View
RecA (PF00154) 31968 (0.6%) View
SKI (PF01202) 30924 (0.6%) View
PRK (PF00485) 29723 (0.6%) View
Fer4_NifH (PF00142) 28057 (0.6%) View
NB-ARC (PF00931) 27431 (0.5%) View
SecA_DEAD (PF07517) 27156 (0.5%) View
ADK (PF00406) 26488 (0.5%) View
PhoH (PF02562) 26261 (0.5%) View
AAA_26 (PF13500) 26127 (0.5%) View
Dynamin_N (PF00350) 25831 (0.5%) View
Bac_DnaA (PF00308) 25759 (0.5%) View
DnaB_C (PF03796) 25596 (0.5%) View
Guanylate_kin (PF00625) 25460 (0.5%) View
AAA_23 (PF13476) 24487 (0.5%) View
AAA_25 (PF13481) 24222 (0.5%) View
Helicase_C_2 (PF13307) 23613 (0.5%) View
UvrD_C_2 (PF13538) 22350 (0.4%) View
RuvB_N (PF05496) 22212 (0.4%) View
AAA_30 (PF13604) 21971 (0.4%) View
AAA_10 (PF12846) 21892 (0.4%) View
IPPT (PF01715) 20882 (0.4%) View
Adenylsucc_synt (PF00709) 20731 (0.4%) View
CTP_synth_N (PF06418) 20410 (0.4%) View
Thymidylate_kin (PF02223) 20119 (0.4%) View
AAA_16 (PF13191) 19837 (0.4%) View
ParA (PF10609) 19832 (0.4%) View
CoaE (PF01121) 19729 (0.4%) View
TsaE (PF02367) 18893 (0.4%) View
DUF258 (PF03193) 18667 (0.4%) View
Cytidylate_kin (PF02224) 18453 (0.4%) View
AAA_12 (PF13087) 18005 (0.4%) View
DNA_pol3_delta (PF06144) 17792 (0.4%) View
Kinesin (PF00225) 17399 (0.3%) View
SbcCD_C (PF13558) 17128 (0.3%) View
ATP_bind_2 (PF03668) 16543 (0.3%) View
AAA_21 (PF13304) 16108 (0.3%) View
FeoB_N (PF02421) 15585 (0.3%) View
Flavi_DEAD (PF07652) 14858 (0.3%) View
KdpD (PF02702) 14805 (0.3%) View
AAA_3 (PF07726) 14795 (0.3%) View
AAA_22 (PF13401) 13920 (0.3%) View
Mg_chelatase (PF01078) 13895 (0.3%) View
FTHFS (PF01268) 13804 (0.3%) View
dNK (PF01712) 13631 (0.3%) View
Myosin_head (PF00063) 13623 (0.3%) View
Terminase_1 (PF03354) 13388 (0.3%) View
AAA_11 (PF13086) 13376 (0.3%) View
TK (PF00265) 13235 (0.3%) View
AFG1_ATPase (PF03969) 13110 (0.3%) View
AAA_27 (PF13514) 12275 (0.2%) View
AAA_19 (PF13245) 11726 (0.2%) View
ArsA_ATPase (PF02374) 11627 (0.2%) View
AAA_14 (PF13173) 11194 (0.2%) View
Terminase_6 (PF03237) 10868 (0.2%) View
PPK2 (PF03976) 10733 (0.2%) View
APS_kinase (PF01583) 10543 (0.2%) View
AAA_33 (PF13671) 10368 (0.2%) View
MobB (PF03205) 10183 (0.2%) View
CobA_CobO_BtuR (PF02572) 9644 (0.2%) View
CobU (PF02283) 9623 (0.2%) View
Arf (PF00025) 9585 (0.2%) View
NACHT (PF05729) 9347 (0.2%) View
Exonuc_V_gamma (PF04257) 9222 (0.2%) View
LpxK (PF02606) 8809 (0.2%) View
DEAD_2 (PF06733) 8774 (0.2%) View
Sulfotransfer_1 (PF00685) 8739 (0.2%) View
Sulfotransfer_3 (PF13469) 8285 (0.2%) View
DUF927 (PF06048) 8243 (0.2%) View
AAA_28 (PF13521) 7878 (0.2%) View
Terminase_GpA (PF05876) 7851 (0.2%) View
AAA_18 (PF13238) 7747 (0.2%) View
T4SS-DNA_transf (PF02534) 7480 (0.1%) View
MCM (PF00493) 7369 (0.1%) View
DUF853 (PF05872) 7045 (0.1%) View
Terminase_3 (PF04466) 6716 (0.1%) View
continued
Pfam family Num. domains Alignment
AAA_32 (PF13654) 6507 (0.1%) View
RNA_helicase (PF00910) 6439 (0.1%) View
ArgK (PF03308) 6365 (0.1%) View
PIF1 (PF05970) 6127 (0.1%) View
PduV-EutP (PF10662) 6074 (0.1%) View
AAA_17 (PF13207) 6013 (0.1%) View
VirE (PF05272) 5511 (0.1%) View
AAA_PrkA (PF08298) 5488 (0.1%) View
ATP_bind_1 (PF03029) 5480 (0.1%) View
Zeta_toxin (PF06414) 5426 (0.1%) View
Helicase_RecD (PF05127) 4923 (0.1%) View
G-alpha (PF00503) 4840 (0.1%) View
Viral_helicase1 (PF01443) 4512 (0.1%) View
DUF463 (PF04317) 4405 (0.1%) View
Septin (PF00735) 4290 (0.1%) View
Rad51 (PF08423) 4106 (0.1%) View
DUF2813 (PF11398) 3967 (0.1%) View
TraG-D_C (PF12696) 3947 (0.1%) View
AAA_6 (PF12774) 3945 (0.1%) View
DUF815 (PF05673) 3912 (0.1%) View
AAA-ATPase_like (PF09820) 3793 (0.1%) View
CBP_BcsQ (PF06564) 3735 (0.1%) View
ERCC3_RAD25_C (PF16203) 3723 (0.1%) View
MukB (PF04310) 3712 (0.1%) View
KaiC (PF06745) 3675 (0.1%) View
Arch_ATPase (PF01637) 3573 (0.1%) View
Sulfotransfer_2 (PF03567) 3559 (0.1%) View
AAA_8 (PF12780) 3474 (0.1%) View
AAA_7 (PF12775) 3459 (0.1%) View
AAA_24 (PF13479) 3347 (0.1%) View
AAA_15 (PF13175) 3117 (0.1%) View
AIG1 (PF04548) 3101 (0.1%) View
DUF87 (PF01935) 3088 (0.1%) View
KAP_NTPase (PF07693) 2952 (0.1%) View
TrwB_AAD_bind (PF10412) 2791 (0.1%) View
Cytidylate_kin2 (PF13189) 2607 (0.1%) View
Sigma54_activ_2 (PF14532) 2516 (0.0%) View
AAA_13 (PF13166) 2381 (0.0%) View
AAA_29 (PF13555) 2200 (0.0%) View
6PF2K (PF01591) 2087 (0.0%) View
DUF2075 (PF09848) 2061 (0.0%) View
CPT (PF07931) 1966 (0.0%) View
Polyoma_lg_T_C (PF06431) 1965 (0.0%) View
Sulphotransf (PF09037) 1951 (0.0%) View
Herpes_Helicase (PF02689) 1895 (0.0%) View
GBP (PF02263) 1851 (0.0%) View
Parvo_NS1 (PF01057) 1819 (0.0%) View
Zot (PF05707) 1770 (0.0%) View
Roc (PF08477) 1638 (0.0%) View
TIP49 (PF06068) 1627 (0.0%) View
PPV_E1_C (PF00519) 1557 (0.0%) View
CLP1_P (PF16575) 1530 (0.0%) View
Gtr1_RagA (PF04670) 1379 (0.0%) View
RHSP (PF07999) 1337 (0.0%) View
Spore_IV_A (PF09547) 1267 (0.0%) View
Pox_A32 (PF04665) 1054 (0.0%) View
TniB (PF05621) 1022 (0.0%) View
AAA_35 (PF14516) 1011 (0.0%) View
ABC_ATPase (PF09818) 1008 (0.0%) View
NOG1 (PF06858) 998 (0.0%) View
DLIC (PF05783) 987 (0.0%) View
RHD3 (PF05879) 935 (0.0%) View
Lon_2 (PF13337) 894 (0.0%) View
AAA_34 (PF13872) 853 (0.0%) View
Helicase_C_4 (PF13871) 804 (0.0%) View
DUF2791 (PF10923) 797 (0.0%) View
Gal-3-0_sulfotr (PF06990) 765 (0.0%) View
KTI12 (PF08433) 764 (0.0%) View
Rad17 (PF03215) 751 (0.0%) View
DUF1611 (PF07755) 708 (0.0%) View
SRPRB (PF09439) 677 (0.0%) View
DAP3 (PF10236) 657 (0.0%) View
CDC73_C (PF05179) 643 (0.0%) View
NTPase_1 (PF03266) 623 (0.0%) View
IIGP (PF05049) 602 (0.0%) View
MEDS (PF14417) 593 (0.0%) View
PAXNEB (PF05625) 592 (0.0%) View
Herpes_TK (PF00693) 591 (0.0%) View
Torsin (PF06309) 532 (0.0%) View
DUF2478 (PF10649) 492 (0.0%) View
CMS1 (PF14617) 474 (0.0%) View
MipZ (PF09140) 437 (0.0%) View
RNA12 (PF10443) 359 (0.0%) View
DUF3584 (PF12128) 341 (0.0%) View
Herpes_ori_bp (PF02399) 319 (0.0%) View
DNA_pack_C (PF02499) 318 (0.0%) View
tRNA_lig_kinase (PF08303) 304 (0.0%) View
HDA2-3 (PF11496) 230 (0.0%) View
Adeno_IVa2 (PF02456) 212 (0.0%) View
Kinesin-relat_1 (PF12711) 206 (0.0%) View
DNA_pack_N (PF02500) 184 (0.0%) View
Kinesin-related (PF06548) 182 (0.0%) View
IPT (PF01745) 157 (0.0%) View
VirC1 (PF07015) 123 (0.0%) View
Microtub_bd (PF16796) 68 (0.0%) View
GvpD (PF07088) 48 (0.0%) View
Podovirus_Gp16 (PF05894) 48 (0.0%) View
NTPase_P4 (PF11602) 9 (0.0%) View
Total: 198 Total: 5072865 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

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Species distribution

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Interactions

There are 553 interactions for this clan. More...

Interacting families
A B
6PF2K 6PF2K
His_Phos_1
AAA AAA
AAA_2
Clp_N
ClpB_D2-small
DNA_pol3_delta2
DNA_PPF
gp45-slide_C
Lon_C
MecA
PCNA_C
PCNA_N
Peptidase_M41
Proteasome
Rep_fac_C
RFC1
RuvB_C
UVR
Vps4_C
AAA_11 AAA_12
AAA_12 AAA_11
AAA_12
AAA_17 AAA_17
AAA_18 AAA_18
AAA_2 AAA
AAA_2
ClpB_D2-small
Proteasome
AAA_21 AAA_21
SMC_N
AAA_22 AAA_22
Cdc6_C
AAA_23 AAA_23
SbcCD_C
SbcD_C
AAA_25 AAA_25
AAA_26 AAA_26
Aminotran_3
DRTGG
AAA_30 AAA_30
UvrD_C_2
AAA_31 AAA_31
CbiA
ParA
AAA_32 AAA_32
Lon_C
Mg_chelatase
AAA_33 AAA_33
PNK3P
AAA_5 AAA_7
AAA_6 AAA_5
Dynein_heavy
AAA_7 AAA_8
Dynein_heavy
AAA_8 AAA_9
MT
ABC_membrane ABC_tran
ABC_tran ABC_membrane
ABC_tran
ABC_tran_Xtn
BPD_transp_1
CFTR_R
TOBE_2
ABC_tran_Xtn ABC_tran
Actin Myosin_head
Adaptin_N Arf
Adenylsucc_synt Adenylsucc_synt
ADK ADK
ADK_lid
ADK_lid ADK
AIG1 AIG1
Aminotran_3 AAA_26
APS_kinase APS_kinase
ATP-sulfurylase
PUA_2
Arch_ATPase Arch_ATPase
Arf Adaptin_N
Ank_2
Arf
Arfaptin
ArfGap
ARL2_Bind_BART
Enterotoxin_a
GMP_PDE_delta
GRIP
PH
Robl_LC7
Sec31
Sec7
TBCC
Arfaptin Ras
ArfGap Arf
ArgK ArgK
ArsA_ATPase ArsA_ATPase
CHD5
GET2
ATP-sulfurylase APS_kinase
ATP-synt ATP-synt_ab
ATP-synt_ab ATP-synt
ATP-synt_ab
ATP-synt_ab_C
ATP-synt_ab_N
ATP-synt_D
ATP-synt_DE
ATP-synt_DE_N
ATP-synt_F6
Hom_end
Hom_end_hint
IATP
Mt_ATP-synt_D
Rho_N
vATP-synt_E
ATP-synt_ab_C ATP-synt_ab
ATP-synt_ab_N ATP-synt_ab
ATP-synt_DE ATP-synt_ab
ATP-synt_DE_N ATP-synt_ab
ATP_bind_1 ATP_bind_1
Bac_DnaA Bac_DnaA
Bac_DnaA_C
Bcl-2 NB-ARC
BH4 NB-ARC
BPD_transp_1 ABC_tran
Btz DEAD
Helicase_C
CARD NB-ARC
CbiA CbiA
MinE
CDC48_N AAA
Cdc6_C AAA_22
CFTR_R ABC_tran
Chromo SNF2_N
Clp_N AAA
ClpB_D2-small AAA_2
CoaE CoaE
CobA_CobO_BtuR Co_AT_N
CobA_CobO_BtuR
CobU CobU
cobW cobW
CobW_C
CRM1_C Ras
CTP_synth_N CTP_synth_N
GATase
CTP_transf_like CoaE
Cytidylate_kin Cytidylate_kin
Cytidylate_kin2 Cytidylate_kin2
dDENN Ras
DEAD Btz
DEAD
DSHCT
HA2
Helicase_C
MA3
Mago_nashi
MIF4G
OB_NTP_bind
PROCT
RIG-I_C-RD
RQC
rRNA_proc-arch
Sec63
Toprim
DEAD_2 Helicase_C_2
DENN Ras
DHC_N2 AAA_5
AAA_6
DHR-2 Ras
DNA_pack_C DNA_pack_C
DNA_pol3_beta_2 DNA_pol3_delta
DNA_pol3_beta_3 DNA_pol3_delta
DNA_pol3_delt_C DNA_pol3_delta2
DNA_pol3_delta DNA_pol3_delt_C
DNA_pol3_delta
DNA_pol3_delta2
DNA_pol3_gamma3
DNA_pol3_delta2 DNA_pol3_delta2
DNA_pol3_gamma3
DNApol3-delta_C
Rep_fac_C
DNA_pol3_gamma3 DNA_pol3_delta2
DnaB DnaB_C
DnaB_C DnaB
DnaB_C
Intein_splicing
dNK dNK
Drf_GBD Ras
DrrA_P4M Ras
DSHCT DEAD
Helicase_C
DUF1611 DUF1611
DUF1726 Helicase_RecD
DUF258 DUF258
Dynamin_M Dynamin_N
Dynamin_N Dynamin_M
Dynamin_N
GED
Dynein_heavy AAA_7
EF-hand_7 Myosin_head
EF_TS GTP_EFTU
EFG_II GTP_EFTU
EFG_IV GTP_EFTU
eIF2_C GTP_EFTU
Epsilon_antitox Zeta_toxin
eRF1_1 GTP_EFTU
EspG Arf
Ras
Exonuc_V_gamma AAA_30
FecCD ABC_tran
FeoB_N FeoB_N
FeoC
Fer4 ABC_tran
Fer4_NifH Fer4_NifH
Oxidored_nitro
FERM_M Ras
Flavi_DEAD Flavi_DEAD
Helicase_C
FTHFS FTHFS
FtsK_SpoIIIE FtsK_SpoIIIE
FYVE_2 Ras
G-alpha 7tm_1
EF-hand_like
G-alpha
GoLoco
PDE6_gamma
PI-PLC-Y
PLC-beta_C
RGS
RGS-like
RhoGEF
WD40
GBP GBP
GBP_C
GBP_C GBP
GDI Ras
Gelsolin Arf
GMP_PDE_delta G-alpha
GRIP Arf
GTP1_OBG MMR_HSR1
GTP_EFTU EF1_GNE
EF_TS
EFG_C
EFG_II
eIF-5_eIF-2B
eIF2_C
EIF_2_alpha
eRF1_1
eRF1_2
GTP_EFTU
GTP_EFTU_D2
GTP_EFTU_D3
IF-2
LepA_C
RIBIOP_C
RNA_replicase_B
UBA
GTP_EFTU_D2 GTP_EFTU
GTP_EFTU_D3 GTP_EFTU
Gtr1_RagA Gtr1_RagA
Guanylate_cyc G-alpha
Guanylate_kin Guanylate_kin
SH3_2
VGCC_beta4Aa_N
HAS-barrel ATP-synt_ab
HDA2-3 HDA2-3
Helicase_C Btz
DEAD
DSHCT
FDF
Flavi_DEAD
GLE1
HA2
Helicase_C
MA3
Mago_nashi
MIF4G
OB_NTP_bind
PAT1
PROCT
RapA_C
RIG-I_C-RD
rRNA_proc-arch
Sec63
SecA_SW
SecY
SUV3_C
UVR
UvrB
zf-Paramyx-P
Helicase_RecD GNAT_acetyltr_2
Herpes_TK Herpes_TK
HHH_4 AAA_30
HHH_5 Rad51
His_Phos_1 6PF2K
Hom_end ATP-synt_ab
Hom_end_hint ATP-synt_ab
HSDR_N ResIII
HSDR_N_2 ResIII
IBN_N Ras
IIGP IIGP
IPPT IPPT
IPT IPT
IstB_IS21 IstB_IS21
KaiC KaiC
KdpD KdpD
Kinesin Kinesin
Tubulin
Tubulin_C
KTI12 KTI12
LepA_C GTP_EFTU
MA3 DEAD
Helicase_C
Mago_nashi DEAD
Helicase_C
MecA AAA
Methyltransf_6 Helicase_C
Mg_chelatase AAA_32
Lon_C
Mg_chelatase
MipZ MipZ
MMR_HSR1 KH_2
KH_dom-like
MMR_HSR1
MMR_HSR1_C
MnmE_helical
TGS
TrmE_N
YchF-GTPase_C
MobB CFIA_Pcf11
Clp1
MobB
Mss4 Ras
MT AAA_8
MukB KicB
MukB
MukE
SbcCD_C
MutS_II MutS_V
MutS_III MutS_V
MutS_V MutS_II
MutS_V
Myosin_head Actin
Dynamin_M
Dynamin_N
EF-hand_1
EF-hand_6
EF-hand_7
EF-hand_8
IQ
Myosin_head
Myosin_N
Spectrin
Myosin_N Myosin_head
NB-ARC CARD
NB-ARC
WD40
NTF2 Ras
NTPase_P4 NTPase_P4
Oxidored_nitro Fer4_NifH
PAPS_reduct GTP_EFTU
ParA ParA
Parvo_NS1 Parvo_NS1
PAS_9 Ras
PAXNEB Elong_Iki1
PDDEXK_1 Exonuc_V_gamma
UvrD_C
Peptidase_M41 AAA
Peptidase_S29 Flavi_DEAD
Peptidase_S7 Flavi_DEAD
PH Ras
PhoH PhoH
PI3_PI4_kinase Ras
PI3K_rbd Ras
Pkinase Ras
Plexin_cytopl Ras
PNK3P AAA_33
Polyoma_lg_T_C P53
Pol_alpha_B_N
Polyoma_lg_T_C
PPK2 PPK2
PPV_E1_C PPV_E1_C
PPV_E2_N
PPV_E2_N PPV_E1_C
PRK PRK
PRONE Ras
Proteasome AAA
AAA_2
Proteasome_A_N AAA
PUA_2 APS_kinase
RA Ras
RabGAP-TBC Ras
Rad51 BRCA2
HHH_5
Rad51
Rad54_N SNF2_N
Rap_GAP Ras
Ras ADPrib_exo_Tox
CAS_CSE1
CRM1_C
Cse1
Drf_FH3
Drf_GBD
FERM_M
FYVE_2
GMP_PDE_delta
GTPase_binding
HR1
IBN_N
IpaB_EvcA
IpgD
LRR_6
PBD
PDZ
PH
Plexin_cytopl
RA
Rac1
Ran_BP1
Ras
Ras_bdg_2
RasGAP
RasGEF
RasGEF_N
RBD
RBD-FIP
Rbsn
RCC1
Rho_Binding
Rho_GDI
RhoGAP
RhoGEF
RILP
RUN
Sec2p
SopE_GEF
TIG
TPR_1
TRAPP
VPS9
Xpo1
zf-RanBP
RasGEF Ras
RBD-FIP Ras
Rbsn Ras
RCC1 Ras
RecA RecA
Rep_fac_C AAA
DNA_pol3_delta2
ResIII EcoR124_C
Helicase_C
HSDR_N
ResIII
UVR
UvrB
Response_reg Sigma54_activat
RFC1 AAA
DNA_pol3_delta2
RGS G-alpha
RGS-like G-alpha
Rho_RNA_bind ATP-synt_ab
RhoGAP Ras
RhoGEF Ras
Ribosomal_S25 GTP_EFTU
Ribosomal_S9 DUF258
RLI ABC_tran
Roc Roc
RQC DEAD
Helicase_C
RuvA_C RuvB_N
RuvB_N DNA_pol3_delta2
RuvB_C
RuvB_N
SbcCD_C AAA_23
Metallophos
MukB
MukE
SbcCD_C
SbcD_C
SBP_bac_1 Kinesin
Sec23_helical Arf
Sec23_trunk Arf
Sec2p Ras
Sec3-PIP2_bind Ras
Sec7 Arf
SecA_DEAD Helicase_C
SecA_DEAD
SecA_PP_bind
SecA_SW
SecG
SecY
SecA_PP_bind Helicase_C
SecA_SW SecA_DEAD
Septin Septin
SH3_1 Guanylate_kin
SH3_2 Guanylate_kin
Sigma54_activ_2 Sigma54_activ_2
Sigma54_activat Response_reg
Sigma54_activat
SKI SKI
SMC_hinge SMC_N
SMC_N AAA_21
Rad21_Rec8
ScpA_ScpB
SMC_hinge
SMC_N
SNF2_N Helicase_C
RapA_C
SNF2_N
SopE_GEF Ras
SRP-alpha_N SRPRB
SRP54 SRP54
SRP54_N
SRP_SPB
SRP54_N SRP54
SRP_SPB SRP54
SRPRB Ribosomal_L31e
SRPRB
SRX SRPRB
Sulfotransfer_1 Sulfotransfer_1
Sulfotransfer_3 Sulfotransfer_3
Sulphotransf Sulphotransf
Sybindin Ras
T2SSE PT-HINT
T2SSE
Terminase_6 Terminase_6
Thymidylate_kin Thymidylate_kin
TIP49 TIP49
TK TK
TrmE_N MMR_HSR1
Tropomyosin Myosin_head
TrwB_AAD_bind TrwB_AAD_bind
TsaE TsaE
Tubulin Kinesin
Tubulin_C Kinesin
UBA GTP_EFTU
uDENN Ras
UPF0051 ABC_tran
UPF1_Zn_bind AAA_12
UvrD-helicase Exonuc_V_gamma
PDDEXK_1
UvrD-helicase
UvrD_C
UvrD_C Exonuc_V_gamma
PDDEXK_1
UvrD-helicase
UvrD_C
VGCC_beta4Aa_N Guanylate_kin
VPS9 Ras
VWA Mg_chelatase
Xpo1 Ras
YchF-GTPase_C MMR_HSR1
YopE Ras
Zeta_toxin Zeta_toxin
Zot Zot

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...