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1228  structures 33067  species 47  interactions 135237  sequences 377  architectures

Clan: CU_oxidase (CL0026)

Summary

Multicopper oxidase-like domain Add an annotation

Many of the proteins in this family contain multiple similar copies of this plastocyanin-like domain.

This clan contains 9 families and the total number of domains in the clan is 135237. The clan was built by DJ Studholme and RD Finn.

Literature references

  1. Messerschmidt A, Huber R; , Eur J Biochem 1990;187:341-352.: The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and structural relationships. PUBMED:2404764 EPMC:2404764
  2. Messerschmidt A, Ladenstein R, Huber R, Bolognesi M, Avigliano L, Petruzzelli R, Rossi A, Finazzi-Agro A; , J Mol Biol 1992;224:179-205.: Refined crystal structure of ascorbate oxidase at 1.9 A resolution. PUBMED:1548698 EPMC:1548698
  3. Page CC, Moser CC, Chen X, Dutton PL; , Nature 1999;402:47-52.: Natural engineering principles of electron tunnelling in biological oxidation-reduction. PUBMED:10573417 EPMC:10573417
  4. Grossmann JG, Ingledew WJ, Harvey I, Strange RW, Hasnain SS; , Biochemistry 1995;34:8406-8414.: X-ray absorption studies and homology modeling define the structural features that specify the nature of the copper site in rusticyanin. PUBMED:7599131 EPMC:7599131

Members

This clan contains the following 9 member families:

Copper-bind COX2 Cu-oxidase Cu-oxidase_2 Cu-oxidase_3 Cu_bind_like Cupredoxin_1 Ephrin SoxE

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
COX2 (PF00116) 45825 (33.9%) View
Cu-oxidase_3 (PF07732) 26234 (19.4%) View
Cu-oxidase (PF00394) 25014 (18.5%) View
Cu-oxidase_2 (PF07731) 22342 (16.5%) View
Cupredoxin_1 (PF13473) 8071 (6.0%) View
Copper-bind (PF00127) 4260 (3.2%) View
Cu_bind_like (PF02298) 2587 (1.9%) View
Ephrin (PF00812) 802 (0.6%) View
SoxE (PF06525) 102 (0.1%) View
Total: 9 Total: 135237 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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