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1966  structures 6391  species 0  interactions 128588  sequences 7690  architectures

Clan: RdRP (CL0027)


RNA dependent RNA polymerase Add an annotation

This clan represents the replicative RNA dependent RNA polymerase. from a variety of RNA viruses [1].

This clan contains 12 families and the total number of domains in the clan is 128588. The clan was built by A Bateman.

Literature references

  1. Koonin EV; , J Gen Virol 1991;72:2197-2206.: The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses. PUBMED:1895057 EPMC:1895057


This clan contains the following 12 member families:

Birna_RdRp_palm Birna_VP1_thumb DUF6451 Flavi_NS5 Flavi_NS5_thumb Mitovir_RNA_pol RdRP_1 RdRP_2 RdRP_3 RdRP_4 RVT_1 RVT_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RVT_1 (PF00078) 100689 (78.3%) View
RVT_2 (PF07727) 23657 (18.4%) View
DUF6451 (PF20049) 2134 (1.7%) View
RdRP_1 (PF00680) 867 (0.7%) View
RdRP_2 (PF00978) 433 (0.3%) View
Mitovir_RNA_pol (PF05919) 275 (0.2%) View
RdRP_4 (PF02123) 260 (0.2%) View
RdRP_3 (PF00998) 221 (0.2%) View
Birna_RdRp_palm (PF04197) 17 (0.0%) View
Birna_VP1_thumb (PF20488) 13 (0.0%) View
Flavi_NS5 (PF00972) 13 (0.0%) View
Flavi_NS5_thumb (PF20483) 9 (0.0%) View
Total: 12 Total: 128588 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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