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2597  structures 22869  species 66  interactions 741477  sequences 3763  architectures

Clan: AB_hydrolase (CL0028)

Summary

Alpha/Beta hydrolase fold Add an annotation

This catalytic domain is found in a very wide range of enzymes.

This clan contains 67 families and the total number of domains in the clan is 741477. The clan was built by A Bateman.

Literature references

  1. Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag J, Sussman JL, Verschueren KHG, Goldman A; , Protein Eng 1992;5:197-211.: The alpha/beta hydrolase fold PUBMED:1409539 EPMC:1409539

Members

This clan contains the following 67 member families:

Abhydro_lipase Abhydrolase_1 Abhydrolase_2 Abhydrolase_3 Abhydrolase_4 Abhydrolase_5 Abhydrolase_6 Abhydrolase_7 Abhydrolase_8 Acyl_transf_2 Arb2 AXE1 BAAT_C Chlorophyllase Chlorophyllase2 COesterase Cutinase DLH DUF1057 DUF1100 DUF1350 DUF1400 DUF1749 DUF2048 DUF2235 DUF2305 DUF2424 DUF2920 DUF2974 DUF3089 DUF3141 DUF3530 DUF452 DUF676 DUF726 DUF818 DUF829 DUF900 DUF915 EHN Esterase Esterase_phd FSH1 Hydrolase_4 LCAT LIP Lipase Lipase_2 Lipase_3 Ndr PAF-AH_p_II Palm_thioest PE-PPE Peptidase_S10 Peptidase_S15 Peptidase_S28 Peptidase_S37 Peptidase_S9 PGAP1 PhaC_N PHB_depo_C PhoPQ_related Ser_hydrolase Tannase Thioesterase UPF0227 VirJ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Abhydrolase_1 (PF00561) 118167 (15.9%) View
Abhydrolase_5 (PF12695) 114820 (15.5%) View
Abhydrolase_3 (PF07859) 72258 (9.7%) View
Abhydrolase_6 (PF12697) 66767 (9.0%) View
Esterase (PF00756) 51643 (7.0%) View
Hydrolase_4 (PF12146) 42261 (5.7%) View
Peptidase_S9 (PF00326) 29517 (4.0%) View
COesterase (PF00135) 25777 (3.5%) View
Thioesterase (PF00975) 24073 (3.2%) View
DLH (PF01738) 19465 (2.6%) View
PE-PPE (PF08237) 16696 (2.3%) View
Cutinase (PF01083) 15315 (2.1%) View
Peptidase_S15 (PF02129) 14821 (2.0%) View
UPF0227 (PF05728) 9813 (1.3%) View
Ser_hydrolase (PF06821) 8481 (1.1%) View
Peptidase_S10 (PF00450) 8237 (1.1%) View
Lipase_3 (PF01764) 8046 (1.1%) View
Abhydrolase_2 (PF02230) 7624 (1.0%) View
Abhydrolase_8 (PF06259) 7269 (1.0%) View
DUF915 (PF06028) 7062 (1.0%) View
Esterase_phd (PF10503) 5552 (0.7%) View
Abhydrolase_4 (PF08386) 5174 (0.7%) View
PGAP1 (PF07819) 5044 (0.7%) View
LIP (PF03583) 4816 (0.6%) View
DUF1100 (PF06500) 3775 (0.5%) View
DUF2235 (PF09994) 3419 (0.5%) View
Lipase (PF00151) 2747 (0.4%) View
DUF2974 (PF11187) 2681 (0.4%) View
PhaC_N (PF07167) 2608 (0.4%) View
DUF676 (PF05057) 2487 (0.3%) View
Peptidase_S28 (PF05577) 2459 (0.3%) View
AXE1 (PF05448) 2389 (0.3%) View
EHN (PF06441) 2306 (0.3%) View
Tannase (PF07519) 2274 (0.3%) View
continued
Pfam family Num. domains Alignment
LCAT (PF02450) 2204 (0.3%) View
FSH1 (PF03959) 1798 (0.2%) View
Abhydro_lipase (PF04083) 1616 (0.2%) View
BAAT_C (PF08840) 1437 (0.2%) View
DUF900 (PF05990) 1437 (0.2%) View
DUF726 (PF05277) 1244 (0.2%) View
Ndr (PF03096) 1127 (0.2%) View
PhoPQ_related (PF10142) 1070 (0.1%) View
DUF829 (PF05705) 1067 (0.1%) View
PHB_depo_C (PF06850) 1054 (0.1%) View
VirJ (PF06057) 1027 (0.1%) View
Lipase_2 (PF01674) 1016 (0.1%) View
Palm_thioest (PF02089) 962 (0.1%) View
DUF2920 (PF11144) 955 (0.1%) View
PAF-AH_p_II (PF03403) 904 (0.1%) View
DUF452 (PF04301) 848 (0.1%) View
Arb2 (PF09757) 762 (0.1%) View
DUF2305 (PF10230) 645 (0.1%) View
DUF3530 (PF12048) 591 (0.1%) View
DUF1400 (PF07176) 506 (0.1%) View
DUF3141 (PF11339) 476 (0.1%) View
DUF1749 (PF08538) 439 (0.1%) View
DUF2048 (PF09752) 402 (0.1%) View
Abhydrolase_7 (PF12715) 396 (0.1%) View
DUF1350 (PF07082) 355 (0.0%) View
Peptidase_S37 (PF05576) 303 (0.0%) View
DUF3089 (PF11288) 229 (0.0%) View
DUF2424 (PF10340) 190 (0.0%) View
DUF1057 (PF06342) 140 (0.0%) View
Chlorophyllase (PF07224) 130 (0.0%) View
DUF818 (PF05677) 118 (0.0%) View
Chlorophyllase2 (PF12740) 107 (0.0%) View
Acyl_transf_2 (PF02273) 79 (0.0%) View
Total: 67 Total: 741477 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

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Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 66 interactions for this clan. More...

Interacting families
A B
Abhydro_lipase Abhydro_lipase
Abhydrolase_1
Abhydrolase_1 Abhydro_lipase
Abhydrolase_1
Flu_M1
Lipase_chap
Abhydrolase_2 Abhydrolase_2
Abhydrolase_3 Abhydrolase_3
DELLA
Abhydrolase_5 Abhydrolase_5
Abhydrolase_6 Abhydrolase_6
PP-binding
Abhydrolase_7 Abhydrolase_7
Acyl_transf_2 Acyl_transf_2
AXE1 AXE1
BAAT_C BAAT_C
Bile_Hydr_Trans
Bile_Hydr_Trans BAAT_C
COesterase AChE_tetra
COesterase
Laminin_G_2
Toxin_1
Colipase Lipase
Condensation Thioesterase
Cutinase Cutinase
DPPIV_N Peptidase_S9
DUF1100 DUF1100
PTS_EIIA_1
DUF1749 DUF1749
DUF3327 Esterase
DUF915 DUF915
EHN EHN
Esterase DUF3327
Esterase
Flu_M1 Abhydrolase_1
FSH1 FSH1
Hist_deacetyl Arb2
Lipase Colipase
Lipase
PLAT
Lipase3_N Lipase_3
Lipase_2 Lipase_2
Lipase_3 Lipase3_N
Lipase_3
Lipase_chap Abhydrolase_1
Metallophos Abhydrolase_6
Ndr Ndr
PAF-AH_p_II PAF-AH_p_II
Palm_thioest Palm_thioest
Peptidase_S10 PBP
Peptidase_S10
Peptidase_S15 Peptidase_S15
PepX_C
Peptidase_S28 Peptidase_S28
Peptidase_S9 DPPIV_N
Hormone_3
Peptidase_S9
V-set
Peptidase_S9_N Peptidase_S9
PepX_C Peptidase_S15
PepX_N Peptidase_S15
PLAT Lipase
PP-binding Thioesterase
PTS_EIIA_1 DUF1100
Ser_hydrolase Ser_hydrolase
Thioesterase Thioesterase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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