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1416  structures 2066  species 52  interactions 64578  sequences 1286  architectures

Clan: Cupin (CL0029)

Summary

Cupin fold Add an annotation

This clan represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel). The cupin fold is found in a wide variety of enzymes, but notably contains the non-enzymatic seed storage proteins also.

This clan contains 57 families and the total number of domains in the clan is 64578. The clan was built by A Bateman.

Literature references

  1. Dunwell JM; , Biotechnol Genet Eng Rev 1998;15:1-32.: Cupins: a new superfamily of functionally diverse proteins that include germins and plant storage proteins. PUBMED:9573603 EPMC:9573603

Members

This clan contains the following 57 member families:

2OG-Fe_Oxy_2 2OG-FeII_Oxy 2OG-FeII_Oxy_2 2OG-FeII_Oxy_3 2OG-FeII_Oxy_4 2OG-FeII_Oxy_5 3-HAO AraC_binding AraC_binding_2 AraC_N ARD Asp_Arg_Hydrox Auxin_BP CDO_I CENP-C_C CsiD Cupin_1 Cupin_2 Cupin_3 Cupin_4 Cupin_5 Cupin_6 Cupin_7 Cupin_8 DMSP_lyase dTDP_sugar_isom DUF1255 DUF1479 DUF1498 DUF1637 DUF1971 DUF386 DUF4437 DUF4867 Ectoine_synth EutQ FdtA FTO_NTD GPI HgmA HutD JmjC KduI MannoseP_isomer Ofd1_CTDD Oxygenase-NA PhyH Pirin Pirin_C PMI_typeI Popeye Pox_C4_C10 TauD Tet_JBP Ureidogly_lyase VIT VIT_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cupin_2 (PF07883) 8307 (12.9%) View
2OG-FeII_Oxy (PF03171) 6821 (10.6%) View
AraC_binding (PF02311) 4179 (6.5%) View
2OG-FeII_Oxy_3 (PF13640) 3780 (5.9%) View
JmjC (PF02373) 3652 (5.7%) View
TauD (PF02668) 3572 (5.5%) View
Cupin_1 (PF00190) 3544 (5.5%) View
PhyH (PF05721) 2855 (4.4%) View
2OG-FeII_Oxy_2 (PF13532) 2555 (4.0%) View
Cupin_8 (PF13621) 2517 (3.9%) View
Pirin (PF02678) 2317 (3.6%) View
dTDP_sugar_isom (PF00908) 1506 (2.3%) View
PMI_typeI (PF01238) 1504 (2.3%) View
Pirin_C (PF05726) 1500 (2.3%) View
VIT (PF08487) 1096 (1.7%) View
MannoseP_isomer (PF01050) 934 (1.4%) View
HgmA (PF04209) 884 (1.4%) View
Cupin_4 (PF08007) 766 (1.2%) View
ARD (PF03079) 728 (1.1%) View
AraC_binding_2 (PF14525) 726 (1.1%) View
Cupin_3 (PF05899) 701 (1.1%) View
Asp_Arg_Hydrox (PF05118) 634 (1.0%) View
KduI (PF04962) 623 (1.0%) View
CDO_I (PF05995) 617 (1.0%) View
Cupin_6 (PF12852) 612 (0.9%) View
AraC_N (PF06719) 583 (0.9%) View
Cupin_5 (PF06172) 563 (0.9%) View
Cupin_7 (PF12973) 513 (0.8%) View
DUF1637 (PF07847) 463 (0.7%) View
continued
Pfam family Num. domains Alignment
DUF386 (PF04074) 427 (0.7%) View
Ureidogly_lyase (PF04115) 406 (0.6%) View
3-HAO (PF06052) 385 (0.6%) View
DUF1479 (PF07350) 353 (0.5%) View
Ofd1_CTDD (PF10637) 339 (0.5%) View
2OG-FeII_Oxy_4 (PF13661) 338 (0.5%) View
Tet_JBP (PF12851) 313 (0.5%) View
Popeye (PF04831) 295 (0.5%) View
DUF1255 (PF06865) 271 (0.4%) View
CENP-C_C (PF11699) 260 (0.4%) View
FdtA (PF05523) 242 (0.4%) View
HutD (PF05962) 232 (0.4%) View
Ectoine_synth (PF06339) 194 (0.3%) View
EutQ (PF06249) 191 (0.3%) View
2OG-Fe_Oxy_2 (PF10014) 185 (0.3%) View
Oxygenase-NA (PF09859) 153 (0.2%) View
2OG-FeII_Oxy_5 (PF13759) 138 (0.2%) View
DUF1971 (PF09313) 121 (0.2%) View
VIT_2 (PF13757) 118 (0.2%) View
GPI (PF06560) 108 (0.2%) View
DUF1498 (PF07385) 95 (0.1%) View
DUF4867 (PF16161) 94 (0.1%) View
FTO_NTD (PF12933) 80 (0.1%) View
Auxin_BP (PF02041) 61 (0.1%) View
DMSP_lyase (PF16867) 42 (0.1%) View
DUF4437 (PF14499) 41 (0.1%) View
CsiD (PF08943) 34 (0.1%) View
Pox_C4_C10 (PF03336) 10 (0.0%) View
Total: 57 Total: 64578
No alignment ℹ
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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