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1240  structures 19610  species 14  interactions 106504  sequences 1205  architectures

Clan: Ion_channel (CL0030)

Summary

Ion channel (VIC) superfamily Add an annotation

This superfamily contains a diverse range of ion channels that share a pair of transmembrane helices in common. This clan is classified as the VIC (Voltage-gated Ion Channel) superfamily in TCDB.

This clan contains 7 families and the total number of domains in the clan is 106504. The clan was built by A Bateman.

Members

This clan contains the following 7 member families:

Ion_trans Ion_trans_2 IRK KdpA Lig_chan PKD_channel TrkH

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ion_trans (PF00520) 35054 (32.9%) View
TrkH (PF02386) 26794 (25.2%) View
Ion_trans_2 (PF07885) 20182 (18.9%) View
KdpA (PF03814) 15237 (14.3%) View
Lig_chan (PF00060) 4923 (4.6%) View
IRK (PF01007) 2263 (2.1%) View
PKD_channel (PF08016) 2051 (1.9%) View
Total: 7 Total: 106504 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 14 interactions for this clan. More...

Interacting families
A B
Ion_trans DSPc
Ion_trans
PTEN_C2
Ion_trans_2 Ion_trans_2
IRK IRK
IRK_N
WD40
IRK_N IRK
Lig_chan Lig_chan
Lig_chan-Glu_bd
SBP_bac_3
Lig_chan-Glu_bd Lig_chan
SBP_bac_3 Lig_chan
TrkH TrkH

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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