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1020  structures 20982  species 30  interactions 309334  sequences 582  architectures

Clan: Amidohydrolase (CL0034)

Summary

Amidohydrolase superfamily Add an annotation

This family includes a large family of metal dependent amidohydrolase enzymes [1].

This clan contains 14 families and the total number of domains in the clan is 309334. The clan was built by A Bateman.

Literature references

  1. Holm L, Sander C; , Proteins 1997;28:72-82.: An evolutionary treasure: unification of a broad set of amidohydrolases related to urease. PUBMED:9144792 EPMC:9144792

Members

This clan contains the following 14 member families:

A_deaminase Amidohydro_1 Amidohydro_2 Amidohydro_3 DHOase DUF3604 Peptidase_M19 PHP PHP_C PTE RNase_P_p30 TatD_DNase Urease_alpha UxaC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Amidohydro_1 (PF01979) 114539 (37.0%) View
PHP (PF02811) 54515 (17.6%) View
TatD_DNase (PF01026) 33022 (10.7%) View
Amidohydro_3 (PF07969) 32778 (10.6%) View
Amidohydro_2 (PF04909) 25624 (8.3%) View
A_deaminase (PF00962) 15176 (4.9%) View
Urease_alpha (PF00449) 11448 (3.7%) View
Peptidase_M19 (PF01244) 6888 (2.2%) View
PTE (PF02126) 6186 (2.0%) View
UxaC (PF02614) 5946 (1.9%) View
PHP_C (PF13263) 1586 (0.5%) View
RNase_P_p30 (PF01876) 886 (0.3%) View
DUF3604 (PF12228) 669 (0.2%) View
DHOase (PF12890) 71 (0.0%) View
Total: 14 Total: 309334 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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