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680  structures 5405  species 12  interactions 63766  sequences 539  architectures

Clan: Peptidase_MH (CL0035)


Peptidase clan MH/MC/MF Add an annotation

This clan contains peptidases belonging to MEROPS clan MH, MC and MF. We also include Nicastrin that is part of the gamma secretase complex and not known to be a peptidase.

This clan contains 12 families and the total number of domains in the clan is 63766. The clan was built by A Bateman.


This clan contains the following 12 member families:

Amidase_3 AstE_AspA DUF2172 DUF2817 Nicastrin Peptidase_M14 Peptidase_M17 Peptidase_M18 Peptidase_M20 Peptidase_M28 Peptidase_M42 SpoIIP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_M20 (PF01546) 29469 (46.2%) View
Amidase_3 (PF01520) 7380 (11.6%) View
Peptidase_M14 (PF00246) 5755 (9.0%) View
Peptidase_M28 (PF04389) 5682 (8.9%) View
Peptidase_M17 (PF00883) 5342 (8.4%) View
Peptidase_M42 (PF05343) 4278 (6.7%) View
AstE_AspA (PF04952) 2822 (4.4%) View
Peptidase_M18 (PF02127) 1876 (2.9%) View
SpoIIP (PF07454) 584 (0.9%) View
Nicastrin (PF05450) 234 (0.4%) View
DUF2172 (PF09940) 203 (0.3%) View
DUF2817 (PF10994) 141 (0.2%) View
Total: 12 Total: 63766 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 12 interactions for this clan. More...

Interacting families
AstE_AspA AstE_AspA
Peptidase_M18 Peptidase_M18
Peptidase_M28 PA
Peptidase_M42 Peptidase_M42
Peptidase_M17 Peptidase_M17
Peptidase_M14 Peptidase_M14
Peptidase_M20 Peptidase_M20


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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