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380  structures 344  species 19  interactions 14280  sequences 1589  architectures

Clan: Death (CL0041)


Death Domain Superfamily Add an annotation

The death domain superfamily is composed of three families: the death domain (DD); the death effector domain (DED) and the caspase recruitment domain (CARD). All of the members perform a pivotal role in signalling events that regulate apoptosis. Protein-protein interactions are mediated by self-self associations, in which CARD-CARD, DD-DD and DED-DED contacts are formed exclusively The three families possess remarkably similar structures, each comprising an antiparallel six helical bundle in the Greek Key topology. Structurally, the DD and CARD families are the most dissimilar. The former is comprised of two perpendicular three-helix bundles, whereas the latter CARD domain contains six helices that are almost parallel with each other. Interestingly, the interactions in CARD or DD containing heterodimers are quite different [1].

This clan contains 7 families and the total number of domains in the clan is 14280. The clan was built by RD Finn.

Literature references

  1. Weber CH, Vincenz C; , Trends Biochem Sci 2001;26:475-481.: The death domain superfamily: a tale of two interfaces?. PUBMED:11504623 EPMC:11504623


This clan contains the following 7 member families:

Atypical_Card CARD CARD_2 Death Death_2 DED PYRIN

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Death (PF00531) 6961 (48.7%) View
CARD (PF00619) 3626 (25.4%) View
DED (PF01335) 1591 (11.1%) View
PYRIN (PF02758) 1373 (9.6%) View
CARD_2 (PF16739) 537 (3.8%) View
Death_2 (PF14786) 98 (0.7%) View
Atypical_Card (PF18461) 94 (0.7%) View
Total: 7 Total: 14280 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 19 interactions for this clan. More...

Interacting families
Bcl-2 CARD
Death Death
Death_2 Death
DED Death
EF-hand_1 Death
EF-hand_7 Death
EF-hand_8 Death
Pkinase DED
SBP_bac_1 CARD
SBP_bac_8 CARD
ZU5 Death


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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