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689  structures 7685  species 10  interactions 52118  sequences 189  architectures

Clan: Chelatase (CL0043)


Chelatase Superfamily Add an annotation

Metallated tetrapyrroles are used as prosthetic groups in proteins involved in biologically important processes such as photosynthesis, oxygen transport, drug metabolism and nitric oxide synthesis. In living organisms, metallation is catalysed by a group of enzymes called chelatases. This clan contains ferrochelatase (heme) and cobalt chelatase [1].

This clan contains 7 families and the total number of domains in the clan is 52118. The clan was built by RD Finn.

Literature references

  1. Lecerof D, Fodje MN, Alvarez Leon R, Olsson U, Hansson A, Sigfridsson E, Ryde U, Hansson M, Al-Karadaghi S; , J Biol Inorg Chem 2003;8:452-458.: Metal binding to Bacillus subtilis ferrochelatase and interaction between metal sites. PUBMED:12761666 EPMC:12761666


This clan contains the following 7 member families:

CbiK CbiX DUF3364 Ferrochelatase Oxidored_nitro Peripla_BP_2 ZnuA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peripla_BP_2 (PF01497) 22085 (42.4%) View
ZnuA (PF01297) 8980 (17.2%) View
Ferrochelatase (PF00762) 7132 (13.7%) View
CbiX (PF01903) 7024 (13.5%) View
Oxidored_nitro (PF00148) 5579 (10.7%) View
CbiK (PF06180) 946 (1.8%) View
DUF3364 (PF11844) 372 (0.7%) View
Total: 7 Total: 52118 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 10 interactions for this clan. More...

Interacting families
CbiX CbiX
DUF3364 Oxidored_nitro
FecCD Peripla_BP_2
Fer4_NifH Oxidored_nitro
Ferrochelatase Ferrochelatase
Oxidored_nitro DUF3364
Peripla_BP_2 Peripla_BP_2
ZnuA ZnuA


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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