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2058  structures 6054  species 13  interactions 34310  sequences 121  architectures

Clan: Ferritin (CL0044)


Ferritin-like Superfamily Add an annotation

The members of this clan all share a distinctive four helical bundle. The four helices are arranged antiparallel with a left-handed twist. This helical bundle is distinguished from others by the long connection between the second and third helices. Some of the members contain a Fe or Mn dimer at the centre of the helical bundle. The ferritin fold was first described by Murzin AG and Chothia C, Cur Opin Struc Biol 1992, 2:895-903.

This clan contains 19 families and the total number of domains in the clan is 34310. The clan was built by RD Finn.


This clan contains the following 19 member families:

Coat_F COQ7 DUF2202 DUF2383 DUF305 DUF4142 DUF4439 DUF892 FA_desaturase_2 Ferritin Ferritin-like Ferritin_2 MiaE MiaE_2 Mn_catalase PaaA_PaaC Phenol_Hydrox Ribonuc_red_sm Rubrerythrin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ferritin (PF00210) 10640 (31.0%) View
Ribonuc_red_sm (PF00268) 7021 (20.5%) View
Rubrerythrin (PF02915) 3551 (10.3%) View
DUF892 (PF05974) 1538 (4.5%) View
PaaA_PaaC (PF05138) 1413 (4.1%) View
DUF305 (PF03713) 1321 (3.9%) View
Mn_catalase (PF05067) 1280 (3.7%) View
Phenol_Hydrox (PF02332) 1141 (3.3%) View
MiaE (PF06175) 1063 (3.1%) View
FA_desaturase_2 (PF03405) 926 (2.7%) View
COQ7 (PF03232) 840 (2.4%) View
DUF4142 (PF13628) 804 (2.3%) View
Coat_F (PF07875) 780 (2.3%) View
Ferritin_2 (PF13668) 660 (1.9%) View
DUF2383 (PF09537) 432 (1.3%) View
DUF4439 (PF14530) 325 (0.9%) View
MiaE_2 (PF13794) 288 (0.8%) View
Ferritin-like (PF12902) 153 (0.4%) View
DUF2202 (PF09968) 134 (0.4%) View
Total: 19 Total: 34310 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 13 interactions for this clan. More...

Interacting families
Phenol_Hydrox Phenol_Hydrox
Mn_catalase Mn_catalase
Ribonuc_red_sm Ribonuc_red_sm
Ferritin Ferritin
FA_desaturase_2 FA_desaturase_2
Rubrerythrin Rubredoxin
MiaE MiaE
DUF305 DUF305


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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