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2851  structures 3153  species 27  interactions 21873  sequences 173  architectures

Clan: Ferritin (CL0044)


Ferritin-like Superfamily Add an annotation

The members of this clan all share a distinctive four helical bundle. The four helices are arranged antiparallel with a left-handed twist. This helical bundle is distinguished from others by the long connection between the second and third helices. Some of the members contain a Fe or Mn dimer at the centre of the helical bundle. The ferritin fold was first described by Murzin AG and Chothia C, Cur Opin Struc Biol 1992, 2:895-903.

This clan contains 21 families and the total number of domains in the clan is 21873. The clan was built by RD Finn.


This clan contains the following 21 member families:

Ald_deCOase AurF Coat_F COQ7 DUF2202 DUF2383 DUF305 DUF4142 DUF4439 DUF892 FA_desaturase_2 Ferritin Ferritin-like Ferritin_2 MiaE MiaE_2 Mn_catalase PaaA_PaaC Phenol_Hydrox Ribonuc_red_sm Rubrerythrin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ferritin (PF00210) 5365 (24.5%) View
Rubrerythrin (PF02915) 3089 (14.1%) View
Ribonuc_red_sm (PF00268) 2803 (12.8%) View
DUF305 (PF03713) 1380 (6.3%) View
Ferritin_2 (PF13668) 1208 (5.5%) View
PaaA_PaaC (PF05138) 937 (4.3%) View
Mn_catalase (PF05067) 918 (4.2%) View
FA_desaturase_2 (PF03405) 882 (4.0%) View
COQ7 (PF03232) 870 (4.0%) View
MiaE (PF06175) 665 (3.0%) View
DUF4142 (PF13628) 637 (2.9%) View
Pfam family Num. domains Alignment
Coat_F (PF07875) 613 (2.8%) View
DUF892 (PF05974) 540 (2.5%) View
AurF (PF11583) 501 (2.3%) View
DUF2383 (PF09537) 401 (1.8%) View
Phenol_Hydrox (PF02332) 284 (1.3%) View
MiaE_2 (PF13794) 212 (1.0%) View
DUF4439 (PF14530) 205 (0.9%) View
Ferritin-like (PF12902) 173 (0.8%) View
DUF2202 (PF09968) 119 (0.5%) View
Ald_deCOase (PF11266) 71 (0.3%) View
Total: 21 Total: 21873 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 27 interactions for this clan. More...

Interacting families
ATP-cone Ribonuc_red_sm
AurF AurF
DUF2202 DUF2202
DUF305 DUF305
DUF4439 DUF4439
DUF892 DUF892
FA_desaturase_2 FA_desaturase_2
Ferritin Fer2_BFD
Ferritin-like Ferritin-like
MiaE MiaE
MiaE_2 MiaE_2
MmoB_DmpM Phenol_Hydrox
Mn_catalase Mn_catalase
PaaA_PaaC PaaA_PaaC
Phenol_Hydrox MeMO_Hyd_G
Ribonuc_red_lgC Ribonuc_red_sm
Ribonuc_red_sm Flavodoxin_NdrI
RNR_N Ribonuc_red_sm
Rubrerythrin Linocin_M18
YHS Phenol_Hydrox


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...