Sequence alignment for CL0047

PF02728

CAO2_SCHPO/105-207---PIITADLLAITDEIVR..NDANVIEQCKICGVPESGLSNVYCDPWTIGYDERYG...SGRRLQQALMYYKPGDS...
AOC3_MOUSE/169-269---RPVLDREYQDIEEMIFHRELPQASGLLHHCCFYKH..QGQNLLTMTTAPRGLQS....GDRATWFGLYYNLSGA...
AOC2_HUMAN/165-263---RPVLRAEFTQMWRHLK..EVELPKAPIFLSS.TFN.YNGSTLAAVHATPRGLRS....GDRATWMALYHNISGV...
AOC1_RAT/141-241---RPISTAEYDLLYHTLKRATMPLHQFFLDTTGFSFLGCDDRCLTFTDVAPRGVAS....GQRRSWFIVQRYVEG....
AOCX_BOVIN/168-268---RPVLLREYLDIDQMIFNRELPQAAGVLHHCCSYKQ..GGQKLLTMNSAPRGVQS....GDRSTWFGIYYNITKG...
Q9STI4_ARATH/177-277---PIVTSEEMDSAASAPF..SNADFNRTINSRG..VN.LTDVICIPISSGWFGNKD..DNTKRVTKIQCFSTQDTP...
A1R2C3_ARTAT/111-210---.PVLLEEFGIIEDILA..VDPQWNAALASRG.LT..PAQVRVAPLSAGVFEYGN..EEGKRLLRGLGFRQDHPA...
A6T8H8_KLEP7/216-317---.MVLLDDFVSVQNIIN..TSSEFAEVLKKHG.ITD.PGKVVTTPLTVGFFDGKDGLQQDARLLKVVSYLDTGDG...
I1KXB5_SOYBN/199-302---PPMDAVEYAECEAVVK..DFPPFREAMKKRG.IED.MDLVMVDPWCAGYHSEAD..APSRRLAKPLIFCRTESDCPM
O23349_ARATH/119-216---PSFTFIELFKASKLPL..TYPPFKKSILDRS..LN.ISEVSCIPFTVGWYGETT....TRRELKASCFYRDGSV...
Q8L742_ARATH/175-274---PMMTIEEMNDITVVPF..SNADFNRTIISRG..VN.LTDVICFPISCGWFGNKE...ENARVIKSQCFMTQGTP...
W1QDC8_OGAPD/114-215---PILTVEDLCATEDVIR..NDPAVIEQCVLSGIPANEMHKVYCDPWTIGYDERWG...TGKRLQQALVYYRSDED...

PF09248

M2TXC2_COCH5/220-286-..TVAPLGFNIKFDVSSR--DWNDWS---------------------VAGWYSVGK-------------FYSSTEE---
R0JI53_SETT2/219-285-..TLQPLGFNVKFDLTSK--NWEDWK---------------------VVGWYSVGE-------------FYATTED---
E3RJ87_PYRTT/219-287-.VTVLPHGFSIKFDLTGR--NWEDWK---------------------VMGWYSYGK-------------FWETADE---
Q0U2Y2_PHANO/234-300-..TLLALGVTVKLDLTGR--DWQDWK---------------------VAGWYSLGE-------------FYDSTES---
N4V1E7_FUSC1/244-311-SETVLPTSLQFKVDLTGR--DPSKWK---------------------VVGWYYDGN-------------FWSTTAA---
A0A098DCG3_GIBZA/250-317-SETILPTSLQFKVDITGR--DPSKWK---------------------VVGWYYDGS-------------YWSTTAE---
C7ZPS7_NECH7/240-307-SETILPTSLQFKLDITGR--DPSKWK---------------------VVGWYYDGN-------------YWPTTAA---
E9E944_METAQ/264-332-SETILPLGLYFGVDVMGR--DPSKWS---------------------VIGWYYDGK-------------YYPTTKA---
L2FSU1_COLGN/263-331-VESMMPMGLFFMSDVTGR--DPSQWT---------------------VEGWYYNGI-------------FYETTEE---
Q0UVX5_PHANO/255-323-VTSNMQMGLFFLSDVTGR--DPSKWT---------------------IEGWYYNGI-------------FYETTEE---
M7TMW6_EUTLA/268-336-SETLLPLGLYFKSEMTGR--DSSQWK---------------------IEGWLYNNI-------------FYATTEE---
A0A0C4DZZ4_MAGP6/268-336-AQSLLPTGLFLLTDVTGR--DPSRWR---------------------LEGWLYNGI-------------FYNSTAA---
R8BSG8_TOGMI/266-334-AETLLPLGLFFKSDVTGR--DPSKWK---------------------LEGWLYNNI-------------FYATTEE---
G4UWG4_NEUT9/270-338-AETLLPLGLYFVSDITGR--DPSKWS---------------------LEGWLYNGT-------------FYATTEE---
B2AMT0_PODAN/268-336-DMTLFPLGLYFSSEVSGR--DPSKWE---------------------LRGWLYNSV-------------FYATTEE---
K2RHS0_MACPH/259-327-ADTLLPLGLYFSLNITGR--DPNLWK---------------------LQGWYYNGV-------------FYETTED---
R1GHV8_BOTPV/238-306-EETLLPLGLYFSGNITGR--DPSLWT---------------------FEGWLYNNE-------------FYTTTEE---
Q2U101_ASPOR/259-327-TGSILPLGLFFKSDVTGR--DPSQWK---------------------LEGWLYNDI-------------FYETTEA---
G7XHV3_ASPKW/193-258-...ILPLGLFFKSDVTGR--DPSKWK---------------------LEGWFYNNT-------------FYETTNA---
Q5B038_EMENI/270-338-SETLLPLGLYLKSDVTGR--DPSQWK---------------------LLGWMYNDI-------------FYETTEE---
R7YS33_CONA1/182-250-VETLLPLGLYFKADVTGR--DPAGWS---------------------VEGWFYNGI-------------FYSTTEE---
J4KM93_BEAB2/880-946-.MSLLSQNLYVKIDTTGR--DPRNWK---------------------VLNWFYNDV-------------LYNSTEA---
A8NZT0_COPC7/270-338-VETLVPQGLYLKLDITGR--DPAGWK---------------------LLGIYYGGI-------------FYESAAA---
M7XDI7_RHOT1/242-312-GETLLPQGLYMKFDFTGR--DPSGWA---------------------FLGWLHDGI-------------FYPTTAD---
Q5KEB2_CRYNJ/253-321-GETLLPQGLYIQTDITGR--DRSKWA---------------------LMGILYGDD-------------YYTSVDE---
U4KXS2_PYROM/245-314-TTTLLGQGLFMKFDVTGR--SESEWK---------------------LLNILYDNI-------------MYDSIGE---
D5GIL7_TUBMM/237-305-SSTLLPQGLYLKLDITGR--DMSGWK---------------------LLNILYDNK-------------LYKSIDE---
K2QJH1_MACPH/254-322-AQTLLPQGLFLKTDVTGR--DPSKWR---------------------VLGWFYNNK-------------FYAGTRE---
J3KJQ0_COCIM/249-317-RASVLPLGLHTKINIAGR--DPSKWS---------------------VLGWYYNGN-------------FYKTTEA---
C4JSG1_UNCRE/202-270-RAAVLPLGLYVKVDIYGR--DPSKWS---------------------VHGWFYNGI-------------FYRNTRA---
R0IJB2_SETT2/233-301-PISLLPLGLYMRTDITGR--DPSKWK---------------------VTGWVYNNV-------------FYPTLDD---
F9G6L3_FUSOF/232-300-TISLLPLGLYLRTDITGR--DPSKWK---------------------VTGWVYNNE-------------FYKDLDE---

PF02727

AOC1_HUMAN/39-125QELKAVHSFLWSKKELRLQPSSTTTMA.KNTVFLIEMLLPKKYHVLRF....LDKGERH..PVREARAVIFFGDQE.---
AOC3_HUMAN/66-152EELTAVMRFLTQRLGPGLVDAAQARPS.DNCVFSVELQLPPKAAALAH....LDRGSPP..PAREALAIVFFGRQP.---
AMO_ECOLI/124-210HPLNALTADEIKQAVEIVKASA.DFKP.NTRFTEISLLPPDKEAVWAF.....ALENKPVDQPRKADVIMLDGKHI.---
O23349_ARATH/23-113HPLDPLTPQEINKTSFIVKKSHLGNLK.DLTFHYLDLEEPNKSHVLQWLSPNPSKKPPP..PRRRSFVVVRAGGQT.---
AOC1_RAT/39-125QEIKAVHSFLMNREELGLQPSKEPTLA.KNSVFLIEMLLPKKKHVLKF....LDEGRKG..PNREARAVIFFGAQD.---
Q9STI4_ARATH/84-170HPLDPLTVMEINKVRSILSSHALFASRVPHLLNSVVLEEPDKNLVRQW.....EKGDQL..PPRKASVIARVGGNS.---
A6T8H8_KLEP7/124-209HPLNSLSAAEISEAVTIVKAAP.EFQP.NTRFTEISLHEPDKAAVWAF.....ALQGTPVDAPRTADVVMLDGKHV.---
Q8L742_ARATH/82-167HPLDPLTVSEINKIRSILSSHALFTSGTPHALHTVVLEEPEKNLVRHW.....EKGNPL..PPRKASVIARVGADT.---
W1QDC8_OGAPD/25-108..LDPLSTAEIKAVTSTVKSYF..AGK.QISFNTVTLREPARKAYIQW....KEQGGPL..PPRLAYYVILEAGKPG---

PF02728

CAO2_SCHPO/105-207GHLRSIPLD.FCPIIDVDQKKVIA-IDIPKVRRPIP
AOC3_MOUSE/169-269.GFYPHPIG.LELLIDHKALDPAL-WTIQKVFYQGR
AOC2_HUMAN/165-263.GLFLHPVG.LELLLDHRALDPAH-WTVQQVFYLGH
AOC1_RAT/141-241..YFLHPTG.LEILLDHGSTDVQD-WRVEQLWYNGK
AOCX_BOVIN/168-268.GPYLHPVG.LELLVDHKALDPAD-WTVQKVFFQGR
Q9STI4_ARATH/177-277.NFYMRPIEGLTLLFDLDTKRILE-ITDTGQSIPIP
A1R2C3_ARTAT/111-210DHPWAHPIDGLVAFVDIENRRVNH-LIDDG.PVPVP
A6T8H8_KLEP7/216-317.NYWAHPIENLVAVVDLEAKKIIK-IEEGP.VIPVP
I1KXB5_SOYBN/199-302ENGYARPVEGIHVLVDMQNMVVLE-FEDRK.LVPL.
O23349_ARATH/119-216.NVFTRPIEGITVTIDVDSMQVIK-YSDRF.RKPIP
Q8L742_ARATH/175-274.NFYMRPIEGLTILIDLDTKQVIE-ITDTGRAIPIP
W1QDC8_OGAPD/114-215DSQYSHPLD.FCPIVDTEEKKVIF-IDIPNRRRKV.

PF09248

M2TXC2_COCH5/220-286---FRAAINSPKYKKPSPNVA.GK.WS.ST-DKNGS
R0JI53_SETT2/219-285---FRAAINAADYKVPSPNVQ.GE.WT.ST-DKNGE
E3RJ87_PYRTT/219-287---FRAVINAPDYQIIPPSTQDGD.WS.ST-DQRGE
Q0U2Y2_PHANO/234-300---FLNALSAPEFIRPHANVD.GN.WT.ST-NQQGA
N4V1E7_FUSC1/244-311---FRKGIKTLK.RKPGPVVD.GP.WT.ST-DQKGD
A0A098DCG3_GIBZA/250-317---FKEGSKTLK.RKPGPNVD.GL.WT.ST-DQQGD
C7ZPS7_NECH7/240-307---FRKGIETLT.RRPGTNVD.GS.WT.ST-DQQGE
E9E944_METAQ/264-332---FRAAAASSNFTILGANSD.GP.WA.QI-DKQGN
L2FSU1_COLGN/263-331---FRNAYWSGKVEKLGGNWA.GD.WS.AT-DQQGE
Q0UVX5_PHANO/255-323---FRTAYFSGNFEKLLGNVD.GE.WA.HT-DQRGP
M7TMW6_EUTLA/268-336---FRTAYWTPGFEKLAANVE.GP.WD.RT-DPQGE
A0A0C4DZZ4_MAGP6/268-336---FRTAYWTPGFEKLGVNVE.GD.WA.RT-DHQGP
R8BSG8_TOGMI/266-334---FRAAYWSEGFEKLGANVE.GD.WA.TT-DQQGP
G4UWG4_NEUT9/270-338---FREAYWSSCFKKNGPNVP.GA.WS.AT-DHNGD
B2AMT0_PODAN/268-336---FRAAYWSEDFVKNGPNVD.GD.WA.RT-DKNGE
K2RHS0_MACPH/259-327---FKSAFAAPGFEKLAPNVA.GQ.WT.ST-DQTGE
R1GHV8_BOTPV/238-306---FRTAFSSPGFEKLKPNVG.GS.WA.AT-DQQGE
Q2U101_ASPOR/259-327---FRHAFFSTGFVKLKPNTE.GP.WA.QT-DQRGP
G7XHV3_ASPKW/193-258---FRKAYYSPGFVKLPSNTE.GD.WA.RT-DQQGP
Q5B038_EMENI/270-338---FRKAYWSPGFVKLKPNVD.GA.WA.HT-EQRGP
R7YS33_CONA1/182-250---LRSAFFSPDFVKLPPDED.GL.WI.QT-GQRGP
J4KM93_BEAB2/880-946---FRAAWMAPGFVITPPNLD.GR.WT.HI-DSRS.
A8NZT0_COPC7/270-338---FRAAWEKPDFVRTEKTFV.TQ.SM.MT-NRTGE
M7XDI7_RHOT1/242-312---FRHAWSNGKVAKTTRNAGMNETWI.GT-DRDGA
Q5KEB2_CRYNJ/253-321---FRAAWQKPGFKKFTPNYS.GD.WI.GT-DQTGD
U4KXS2_PYROM/245-314---FRNAWKKPGFHKLPKAED.GD.WAYAT-KHEGK
D5GIL7_TUBMM/237-305---FRAAWKSPGFRKLAKQAD.GE.WA.GT-GQTGT
K2QJH1_MACPH/254-322---FRAAYESPDFQRLKPNVE.GD.WA.RT-DRQGP
J3KJQ0_COCIM/249-317---FRKAYFSPGFQKRGANVD.GL.WA.QL-MRDGE
C4JSG1_UNCRE/202-270---FRKAYFSPGFKKLGANVD.GP.WA.QL-NREGD
R0IJB2_SETT2/233-301---FRKVINQPNFKSLGMNVD.EP.WA.HT-KTHGD
F9G6L3_FUSOF/232-300---FRKVIAEPDFKPLGANLD.QP.WA.HT-NKHGD

PF02727

AOC1_HUMAN/39-125---------.HPNVTEFAVGPLPG-PCYM-------
AOC3_HUMAN/66-152---------.QPNVSELVVGPLPH-PSYM-------
AMO_ECOLI/124-210---------.IEAVVDLQNNKLLS-WQPI-------
O23349_ARATH/23-113---------.YELIIDLTTSKIAS-SRIY-------
AOC1_RAT/39-125---------.YPNVTEFAVGPLPR-PYYI-------
Q9STI4_ARATH/84-170---------.HLLIVDLSTSRVDQ-ADSP-------
A6T8H8_KLEP7/124-209---------.IEAVVDLQNKKILS-WTP.-------
Q8L742_ARATH/82-167---------.HVLTVDISTGRVDS-ENS.-------
W1QDC8_OGAPD/25-108---------VKEGLVDLASLSVIE-TRA.-------

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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