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3250  structures 3107  species 52  interactions 8938  sequences 298  architectures

Clan: Nucleoplasmin (CL0055)


Nucleoplasmin-like/VP (viral coat and capsid proteins) superfamily Add an annotation

This large superfamily includes nucleoplasmin as well as a wide range of viral coat and capsid proteins that share a jelly roll topology.

This clan contains 42 families and the total number of domains in the clan is 8938. The clan was built by RD Finn and A Bateman.


This clan contains the following 42 member families:

Adeno_hexon_C Astro_capsid_N Birna_VP2 Bromo_coat Calici_coat Calici_coat_C Capsid-VNN Capsid_N Carmo_coat_C Circo_capsid Como_LCP Como_SCP CRPV_capsid Cucumo_coat Dicistro_VP4 DUF2961 DUF4621 HAV_VP IHHNV_capsid Ilar_coat Late_protein_L1 Luteo_coat Nepo_coat Nepo_coat_C Nepo_coat_N NPL Nucleoplasmin Peptidase_A21 Peptidase_A6 Pico_P1A Polyhedrin Polyoma_coat Pox_Rif Rhv SP2 TGFb_propeptide TNV_CP TT_ORF1 Tymo_coat Viral_coat VP4_2 Waikav_capsid_1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TGFb_propeptide (PF00688) 3521 (39.4%) View
NPL (PF17800) 1647 (18.4%) View
DUF2961 (PF11175) 956 (10.7%) View
Nucleoplasmin (PF03066) 754 (8.4%) View
Rhv (PF00073) 285 (3.2%) View
Cucumo_coat (PF00760) 246 (2.8%) View
Late_protein_L1 (PF00500) 229 (2.6%) View
Capsid_N (PF16903) 201 (2.2%) View
CRPV_capsid (PF08762) 201 (2.2%) View
Viral_coat (PF00729) 142 (1.6%) View
Dicistro_VP4 (PF11492) 137 (1.5%) View
Adeno_hexon_C (PF03678) 90 (1.0%) View
TT_ORF1 (PF02956) 86 (1.0%) View
Luteo_coat (PF00894) 79 (0.9%) View
Polyoma_coat (PF00718) 65 (0.7%) View
Polyhedrin (PF00738) 60 (0.7%) View
Calici_coat (PF00915) 42 (0.5%) View
Pox_Rif (PF03340) 39 (0.4%) View
Circo_capsid (PF02443) 27 (0.3%) View
Capsid-VNN (PF11729) 21 (0.2%) View
Waikav_capsid_1 (PF12264) 13 (0.1%) View
Ilar_coat (PF01787) 13 (0.1%) View
Pfam family Num. domains Alignment
Peptidase_A21 (PF03566) 11 (0.1%) View
TNV_CP (PF03898) 10 (0.1%) View
Pico_P1A (PF02226) 8 (0.1%) View
Birna_VP2 (PF01766) 8 (0.1%) View
Tymo_coat (PF00983) 7 (0.1%) View
VP4_2 (PF08935) 6 (0.1%) View
DUF4621 (PF15414) 4 (0.0%) View
Como_SCP (PF02248) 4 (0.0%) View
Peptidase_A6 (PF01829) 4 (0.0%) View
Como_LCP (PF02247) 4 (0.0%) View
Carmo_coat_C (PF08462) 3 (0.0%) View
Astro_capsid_N (PF03115) 3 (0.0%) View
HAV_VP (PF12944) 2 (0.0%) View
Nepo_coat_N (PF03689) 2 (0.0%) View
SP2 (PF03014) 2 (0.0%) View
Bromo_coat (PF01318) 2 (0.0%) View
IHHNV_capsid (PF16530) 1 (0.0%) View
Nepo_coat_C (PF03688) 1 (0.0%) View
Calici_coat_C (PF08435) 1 (0.0%) View
Nepo_coat (PF03391) 1 (0.0%) View
Total: 42 Total: 8938
No alignment ℹ

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...