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351  structures 6465  species 0  interactions 36403  sequences 218  architectures

Clan: Met_repress (CL0057)


MetJ/Arc repressor, antitoxin of TA systems superfamily Add an annotation

This superfamily contains many antitoxin families, all of which carry a ribbon-helix-helix DNA-binding motif with the beta-ribbon located in and recognising the major groove of operator DNA [1].

This clan contains 43 families and the total number of domains in the clan is 36403. The clan was built by A Bateman.

Literature references

  1. Murayama K, Orth P, de la Hoz AB, Alonso JC, Saenger W; , J Mol Biol 2001;314:789-796.: Crystal structure of omega transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 A resolution. PUBMED:11733997 EPMC:11733997
  2. Gerdes K, Maisonneuve E;, Annu Rev Microbiol. 2012;66:103-123.: Bacterial persistence and toxin-antitoxin Loci. PUBMED:22994490 EPMC:22994490


This clan contains the following 43 member families:

Arc BrnA_antitoxin CcdA CopG_antitoxin DndE DUF1778 DUF1902 DUF2540 DUF2610 DUF6290 DUF6364 HicB HicB-like_2 HicB_lk_antitox MatP_C MetJ MobC MobC_2 Omega_Repress ParB_C ParD ParD_antitoxin ParD_like ParG Plasmid_stab_B PSK_trans_fac RelB RepB-RCR_reg Repressor_Mnt RHH_1 RHH_3 RHH_4 RHH_5 RHH_6 RHH_7 RHH_8 RHH_9 SeqA_N TraY VAPB_antitox VapB_antitoxin VirC2 VirD1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RHH_1 (PF01402) 6215 (17.1%) View
HicB_lk_antitox (PF15919) 3376 (9.3%) View
ParD_antitoxin (PF03693) 2679 (7.4%) View
MobC (PF05713) 2636 (7.2%) View
RelB (PF04221) 2296 (6.3%) View
HicB (PF05534) 2067 (5.7%) View
BrnA_antitoxin (PF14384) 1868 (5.1%) View
RHH_4 (PF13467) 1814 (5.0%) View
DUF1778 (PF08681) 1738 (4.8%) View
VapB_antitoxin (PF09957) 1537 (4.2%) View
Arc (PF03869) 1272 (3.5%) View
ParD_like (PF11903) 851 (2.3%) View
CcdA (PF07362) 847 (2.3%) View
MobC_2 (PF19514) 812 (2.2%) View
PSK_trans_fac (PF07704) 774 (2.1%) View
DUF6364 (PF19891) 579 (1.6%) View
DUF6290 (PF19807) 467 (1.3%) View
RHH_8 (PF17723) 415 (1.1%) View
CopG_antitoxin (PF12441) 412 (1.1%) View
MetJ (PF01340) 378 (1.0%) View
DndE (PF08870) 373 (1.0%) View
RHH_5 (PF07878) 366 (1.0%) View
Pfam family Num. domains Alignment
VAPB_antitox (PF02697) 363 (1.0%) View
RHH_3 (PF12651) 342 (0.9%) View
SeqA_N (PF17206) 340 (0.9%) View
DUF1902 (PF08972) 233 (0.6%) View
MatP_C (PF17414) 223 (0.6%) View
RHH_9 (PF19839) 218 (0.6%) View
TraY (PF05509) 173 (0.5%) View
ParG (PF09274) 155 (0.4%) View
ParD (PF09386) 133 (0.4%) View
ParB_C (PF18064) 94 (0.3%) View
RHH_6 (PF16762) 75 (0.2%) View
RepB-RCR_reg (PF10723) 60 (0.2%) View
Plasmid_stab_B (PF10784) 56 (0.2%) View
DUF2610 (PF11020) 43 (0.1%) View
HicB-like_2 (PF15970) 30 (0.1%) View
Omega_Repress (PF07764) 26 (0.1%) View
VirD1 (PF07328) 21 (0.1%) View
VirC2 (PF07181) 18 (0.0%) View
Repressor_Mnt (PF11423) 17 (0.0%) View
RHH_7 (PF16777) 6 (0.0%) View
DUF2540 (PF10802) 5 (0.0%) View
Total: 43 Total: 36403
No alignment ℹ

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...