Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
3088  structures 22129  species 115  interactions 337405  sequences 3659  architectures

Clan: Glyco_hydro_tim (CL0058)

Summary

Tim barrel glycosyl hydrolase superfamily Add an annotation

This large superfamily contains a range of glycosyl hydrolase enzymes that possess a TIM barrel fold. This CLAN merges clans GH-A, GH-D, GH-H and GH-K from CAZy.

This clan contains 50 families and the total number of domains in the clan is 337405. The clan was built by A Bateman.

Literature references

  1. Naumov DG, Karreras M;, Mol Biol (Mosk). 2009;43:709-721.: [New program PSI protein classifier automatizes the PSI-BLAST results analysis]. PUBMED:19807035 EPMC:19807035

Members

This clan contains the following 50 member families:

Alpha-amylase Alpha_L_fucos Cellulase Cellulase-like DUF4015 DUF4038 DUF4434 DUF4849 GHL1-3 GHL10 GHL13 GHL15 GHL5 GHL6 Glyco_hydr_30_2 Glyco_hydro_1 Glyco_hydro_10 Glyco_hydro_101 Glyco_hydro_114 Glyco_hydro_14 Glyco_hydro_17 Glyco_hydro_18 Glyco_hydro_20 Glyco_hydro_25 Glyco_hydro_26 Glyco_hydro_2_C Glyco_hydro_3 Glyco_hydro_30 Glyco_hydro_31 Glyco_hydro_35 Glyco_hydro_39 Glyco_hydro_42 Glyco_hydro_44 Glyco_hydro_53 Glyco_hydro_56 Glyco_hydro_59 Glyco_hydro_66 Glyco_hydro_70 Glyco_hydro_72 Glyco_hydro_77 Glyco_hydro_79n Glyco_hydro_85 Glyco_hydro_97 Glyco_hydro_cc hDGE_amylase Melibiase Melibiase_2 NAGidase NAGLU Raffinose_syn

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Alpha-amylase (PF00128) 100720 (29.9%) View
Glyco_hydro_1 (PF00232) 44198 (13.1%) View
Glyco_hydro_3 (PF00933) 29740 (8.8%) View
Glyco_hydro_2_C (PF02836) 18828 (5.6%) View
Glyco_hydro_18 (PF00704) 18714 (5.5%) View
Glyco_hydro_31 (PF01055) 15935 (4.7%) View
Cellulase (PF00150) 11685 (3.5%) View
Glyco_hydro_25 (PF01183) 11598 (3.4%) View
Glyco_hydro_77 (PF02446) 10579 (3.1%) View
Glyco_hydro_20 (PF00728) 8961 (2.7%) View
GHL10 (PF02638) 5445 (1.6%) View
Glyco_hydro_35 (PF01301) 5099 (1.5%) View
Alpha_L_fucos (PF01120) 4938 (1.5%) View
Melibiase (PF02065) 4642 (1.4%) View
Glyco_hydro_10 (PF00331) 4027 (1.2%) View
Glyco_hydro_17 (PF00332) 3988 (1.2%) View
GHL13 (PF14883) 3495 (1.0%) View
Glyco_hydro_42 (PF02449) 3308 (1.0%) View
Melibiase_2 (PF16499) 2960 (0.9%) View
Glyco_hydro_30 (PF02055) 2383 (0.7%) View
Glyco_hydro_97 (PF10566) 2115 (0.6%) View
DUF4434 (PF14488) 2062 (0.6%) View
Glyco_hydro_26 (PF02156) 1854 (0.5%) View
Glyco_hydro_53 (PF07745) 1595 (0.5%) View
Glyco_hydro_72 (PF03198) 1446 (0.4%) View
Raffinose_syn (PF05691) 1264 (0.4%) View
continued
Pfam family Num. domains Alignment
NAGidase (PF07555) 1238 (0.4%) View
Glyco_hydro_114 (PF03537) 1179 (0.3%) View
Glyco_hydro_85 (PF03644) 1138 (0.3%) View
Glyco_hydro_cc (PF11790) 1050 (0.3%) View
Glyco_hydro_101 (PF12905) 992 (0.3%) View
NAGLU (PF05089) 975 (0.3%) View
Glyco_hydro_14 (PF01373) 974 (0.3%) View
Glyco_hydro_39 (PF01229) 874 (0.3%) View
DUF4038 (PF13204) 826 (0.2%) View
DUF4015 (PF13200) 826 (0.2%) View
Glyco_hydro_56 (PF01630) 822 (0.2%) View
GHL1-3 (PF11308) 740 (0.2%) View
Glyco_hydro_70 (PF02324) 716 (0.2%) View
DUF4849 (PF16141) 687 (0.2%) View
hDGE_amylase (PF14701) 594 (0.2%) View
Glyco_hydro_79n (PF03662) 544 (0.2%) View
Glyco_hydr_30_2 (PF14587) 504 (0.1%) View
Glyco_hydro_66 (PF13199) 322 (0.1%) View
Glyco_hydro_59 (PF02057) 288 (0.1%) View
GHL6 (PF14871) 190 (0.1%) View
Glyco_hydro_44 (PF12891) 171 (0.1%) View
GHL5 (PF14872) 66 (0.0%) View
Cellulase-like (PF12876) 58 (0.0%) View
GHL15 (PF14885) 52 (0.0%) View
Total: 50 Total: 337405 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 115 interactions for this clan. More...

Interacting families
A B
Alpha-amylase A_amylase_inhib
Alpha-amyl_C
Alpha-amyl_C2
Alpha-amylase
Alpha-amylase_C
Alpha-amylase_N
CBM_20
CBM_48
Cyc-maltodext_C
Cyc-maltodext_N
DUF1921
DUF1939
DUF1945
DUF1953
DUF1964
DUF1966
DUF3372
DUF3416
DUF3459
Kunitz_legume
Lectin_legB
TIG
Tryp_alpha_amyl
Alpha-amylase_C Alpha-amylase
Alpha-amylase_N Alpha-amylase
Alpha_L_fucos Alpha_L_fucos
F5_F8_type_C
Bgal_small_N Glyco_hydro_2_C
CBM_15 Glyco_hydro_10
CBM_2 Cellulase
CBM_20 Glyco_hydro_14
CBM_48 Alpha-amylase
CBM_4_9 Glyco_hydro_10
CBM_5_12 Glyco_hydro_18
Cellulase CBM_17_28
CBM_2
CBM_6
Cellulase
CHB_HEX Glyco_hydro_20
ChitinaseA_N Glyco_hydro_18
Collagen_bind_2 DUF4038
Cyc-maltodext_C Alpha-amylase
Cyc-maltodext_N Alpha-amylase
DUF1735 Glyco_hydro_18
DUF1966 Alpha-amylase
DUF3416 Alpha-amylase
DUF4038 Collagen_bind_2
DUF4038
F5_F8_type_C NAGLU
Fn3-like Glyco_hydro_3
Gal_mutarotas_2 Glyco_hydro_31
GH97_N Glyco_hydro_97
Glyco_hydr_30_2 Glyco_hydr_30_2
Glyco_hydro_1 Glyco_hydro_1
Glyco_hydro_10 Glyco_hydro_10
Ricin_B_lectin
Glyco_hydro_114 Glyco_hydro_114
Glyco_hydro_14 CBM_20
Glyco_hydro_14
Glyco_hydro_17 Glyco_hydro_17
Glyco_hydro_18 CBM_5_12
Glyco_hydro_10
Glyco_hydro_11
Glyco_hydro_18
Glyco_hydro_2 Glyco_hydro_2_C
Glyco_hydro_20 CHB_HEX_C
Glyco_hydro_20
Glycohydro_20b2
Glyco_hydro_20b Glyco_hydro_20
NAGidase
Glyco_hydro_25 CW_binding_1
Glyco_hydro_25
Glyco_hydro_26 Glyco_hydro_26
Glyco_hydro_2_C Bgal_small_N
Glyco_hydro_2
Glyco_hydro_2_C
Glyco_hydro_2_N
Glyco_hydro_2_N Glyco_hydro_2_C
Glyco_hydro_3 Fn3-like
Glyco_hydro_3
Glyco_hydro_3_C
PA14
Glyco_hydro_30 Glyco_hydro_30
Glyco_hydro_31 CBM_6
Gal_mutarotas_2
Glyco_hydro_31
Trefoil
Glyco_hydro_35 BetaGal_dom2
BetaGal_dom3
BetaGal_dom4_5
Glyco_hydro_35
Glyco_hydro_39 Glyco_hydro_39
Glyco_hydro_3_C Glyco_hydro_3
Glyco_hydro_42 Glyco_hydro_42C
Glyco_hydro_42M
Glyco_hydro_44 Alpha-L-AF_C
Glyco_hydro_44
Glyco_hydro_53 Glyco_hydro_53
Glyco_hydro_70 CW_binding_1
Glyco_hydro_70
Glyco_hydro_72 X8
Glyco_hydro_85 Glyco_hydro_85
Glyco_hydro_97 GH97_C
GH97_N
Glyco_hydro_97
Glycohydro_20b2 Glyco_hydro_20
Melibiase Melibiase
NAGidase NAGidase
NAGLU NAGLU_C
NAGLU_N NAGLU
PA14 Glyco_hydro_3
Glyco_hydro_31
PUD Alpha-amylase
Ricin_B_lectin Glyco_hydro_10
Trefoil Glyco_hydro_31

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...