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1560  structures 7712  species 14  interactions 152775  sequences 574  architectures

Clan: PLP_aminotran (CL0061)


PLP dependent aminotransferase superfamily Add an annotation

This superfamily contains a variety of PLP-dependent enzymes.

This clan contains 15 families and the total number of domains in the clan is 152775. The clan was built by A Bateman.


This clan contains the following 15 member families:

Alliinase_C Aminotran_1_2 Aminotran_3 Aminotran_5 Aminotran_MocR Beta_elim_lyase Cys_Met_Meta_PP DegT_DnrJ_EryC1 GDC-P Met_gamma_lyase OKR_DC_1 Pyridoxal_deC SelA SHMT SLA_LP_auto_ag

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Aminotran_1_2 (PF00155) 52439 (34.3%) View
Aminotran_5 (PF00266) 23746 (15.5%) View
Aminotran_3 (PF00202) 23135 (15.1%) View
Cys_Met_Meta_PP (PF01053) 12248 (8.0%) View
DegT_DnrJ_EryC1 (PF01041) 8204 (5.4%) View
Pyridoxal_deC (PF00282) 7254 (4.7%) View
SHMT (PF00464) 6460 (4.2%) View
GDC-P (PF02347) 6351 (4.2%) View
OKR_DC_1 (PF01276) 4944 (3.2%) View
Beta_elim_lyase (PF01212) 4088 (2.7%) View
SelA (PF03841) 2029 (1.3%) View
Met_gamma_lyase (PF06838) 999 (0.7%) View
Aminotran_MocR (PF12897) 444 (0.3%) View
SLA_LP_auto_ag (PF05889) 254 (0.2%) View
Alliinase_C (PF04864) 180 (0.1%) View
Total: 15 Total: 152775 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 14 interactions for this clan. More...

Interacting families
Beta_elim_lyase Beta_elim_lyase
Aminotran_5 Aminotran_5
Pyridoxal_deC Pyridoxal_deC
Aminotran_3 Aminotran_3
DegT_DnrJ_EryC1 DegT_DnrJ_EryC1
Aminotran_1_2 Aminotran_1_2
Alliinase_C EGF_alliinase
Cys_Met_Meta_PP Cys_Met_Meta_PP


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...