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134  structures 20596  species 4  interactions 588872  sequences 779  architectures

Clan: APC (CL0062)


APC superfamily Add an annotation

This large superfamily contains a variety of transporters including amino acid permeases that according to TCDB belong to the APC (Amino acid-Polyamine-organoCation) superfamily.

This clan contains 20 families and the total number of domains in the clan is 588872. The clan was built by A Bateman.


This clan contains the following 20 member families:

AA_permease AA_permease_2 AA_permease_C Aa_trans BCCT BenE Branch_AA_trans CstA HCO3_cotransp K_trans MFS_MOT1 Na_Ala_symp Nramp SNF Spore_permease SSF Sulfate_transp Transp_cyt_pur Trp_Tyr_perm Xan_ur_permease

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AA_permease_2 (PF13520) 112943 (19.2%) View
AA_permease (PF00324) 93344 (15.9%) View
Xan_ur_permease (PF00860) 71441 (12.1%) View
SSF (PF00474) 45830 (7.8%) View
BCCT (PF02028) 32309 (5.5%) View
Sulfate_transp (PF00916) 32101 (5.5%) View
SNF (PF00209) 31163 (5.3%) View
Na_Ala_symp (PF01235) 25025 (4.2%) View
Nramp (PF01566) 24562 (4.2%) View
Branch_AA_trans (PF05525) 24086 (4.1%) View
Trp_Tyr_perm (PF03222) 21903 (3.7%) View
Transp_cyt_pur (PF02133) 18941 (3.2%) View
CstA (PF02554) 16031 (2.7%) View
Aa_trans (PF01490) 12652 (2.1%) View
K_trans (PF02705) 9694 (1.6%) View
BenE (PF03594) 6906 (1.2%) View
Spore_permease (PF03845) 3831 (0.7%) View
HCO3_cotransp (PF00955) 3605 (0.6%) View
AA_permease_C (PF13906) 1603 (0.3%) View
MFS_MOT1 (PF16983) 902 (0.2%) View
Total: 20 Total: 588872 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
AA_permease_2 AA_permease_2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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