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35  structures 20184  species 1  interaction 195162  sequences 259  architectures

Clan: CPA_AT (CL0064)


CPA/AT transporter superfamily Add an annotation

This Clan contains transporter proteins that belong to the CPA superfamily and AT superfamily according to TCDB [1].

This clan contains 13 families and the total number of domains in the clan is 195162. The clan was built by A Bateman.

Literature references

  1. Chang AB, Lin R, Keith Studley W, Tran CV, Saier MH Jr; , Mol Membr Biol 2004;21:171-181.: Phylogeny as a guide to structure and function of membrane transport proteins. PUBMED:15204625 EPMC:15204625


This clan contains the following 13 member families:

Asp-Al_Ex Cons_hypoth698 DUF340 DUF819 Glt_symporter KdgT Mem_trans Na_H_antiport_1 Na_H_Exchanger OAD_beta SBF SBF_like Sbt_1

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Na_H_Exchanger (PF00999) 68622 (35.2%) View
Mem_trans (PF03547) 29036 (14.9%) View
Asp-Al_Ex (PF06826) 19646 (10.1%) View
SBF (PF01758) 18290 (9.4%) View
Cons_hypoth698 (PF03601) 13805 (7.1%) View
Glt_symporter (PF03616) 11077 (5.7%) View
Na_H_antiport_1 (PF06965) 7366 (3.8%) View
SBF_like (PF13593) 6363 (3.3%) View
DUF340 (PF03956) 6046 (3.1%) View
OAD_beta (PF03977) 5799 (3.0%) View
KdgT (PF03812) 4871 (2.5%) View
Sbt_1 (PF05982) 2301 (1.2%) View
DUF819 (PF05684) 1940 (1.0%) View
Total: 13 Total: 195162 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families
Na_H_antiport_1 Na_H_antiport_1


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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