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323  structures 1311  species 36  interactions 26573  sequences 249  architectures

Clan: Cyclin (CL0065)

Summary

Cyclin-like superfamily Add an annotation

This Clan contains cyclins, Transcription factor IIB (TFIIB), and the Retinoblastoma tumour suppressor proteins. These were predicted to be related by sequence [1].

This clan contains 8 families and the total number of domains in the clan is 26573. The clan was built by A Bateman.

Literature references

  1. Gibson TJ, Thompson JD, Blocker A, Kouzarides T; , Nucleic Acids Res 1994;22:946-952.: Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107. PUBMED:8152925 EPMC:8152925
  2. Noble ME, Endicott JA, Brown NR, Johnson LN; , Trends Biochem Sci 1997;22:482-487.: The cyclin box fold: protein recognition in cell-cycle and transcription control. PUBMED:9433129 EPMC:9433129

Members

This clan contains the following 8 member families:

CDK5_activator Cyclin Cyclin_C Cyclin_C_2 Cyclin_N RB_A RB_B TFIIB

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cyclin_N (PF00134) 10953 (41.2%) View
TFIIB (PF00382) 5659 (21.3%) View
Cyclin_C (PF02984) 5338 (20.1%) View
Cyclin (PF08613) 2480 (9.3%) View
Cyclin_C_2 (PF16899) 718 (2.7%) View
RB_A (PF01858) 584 (2.2%) View
RB_B (PF01857) 576 (2.2%) View
CDK5_activator (PF03261) 265 (1.0%) View
Total: 8 Total: 26573 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 36 interactions for this clan. More...

Interacting families
A B
Cyclin Cyclin
Pkinase
Cyclin_C Cyclin_C
Cyclin_N
Pkinase
Cyclin_N CDI
Cyclin_C
Cyclin_N
Herp-Cyclin
K-cyclin_vir_C
Pkinase
Rb_C
Tat
DUF3452 RB_A
RB_B
K-cyclin_vir_C Cyclin_N
Pkinase CDK5_activator
Cyclin
Cyclin_C
Cyclin_N
RB_A Adeno_E1A
RB_A
RB_B
Rb_C
RB_B Adeno_E1A
RB_A
Rb_C
Rb_C RB_A
RB_B
RNA_pol_Rpb1_1 TFIIB
RNA_pol_Rpb2_1 TFIIB
RNA_pol_Rpb2_6 TFIIB
TBP TFIIB
TFIIB HSV_VP16_C
TBP
TFIIB

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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