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235  structures 19473  species 28  interactions 169058  sequences 261  architectures

Clan: ACT (CL0070)

Summary

ACT-like domain Add an annotation

These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains [1]. The relationship between these two families was first noticed in [2].

This clan contains 9 families and the total number of domains in the clan is 169058. The clan was built by A Bateman.

Literature references

  1. Anantharaman V, Koonin EV, Aravind L; , J Mol Biol 2001;307:1271-1292.: Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. PUBMED:11292341 EPMC:11292341
  2. Murzin AG, Bateman A; , Proteins 1997;1:105-112.: Distant homology recognition using structural classification of proteins. PUBMED:9485501 EPMC:9485501

Members

This clan contains the following 9 member families:

ACT ACT_3 ACT_4 ACT_5 ACT_6 ACT_7 DUF493 NikR_C Thr_dehydrat_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ACT (PF01842) 62637 (37.1%) View
ACT_4 (PF13291) 28000 (16.6%) View
Thr_dehydrat_C (PF00585) 20980 (12.4%) View
ACT_7 (PF13840) 18309 (10.8%) View
ACT_5 (PF13710) 14521 (8.6%) View
ACT_6 (PF13740) 12151 (7.2%) View
DUF493 (PF04359) 6525 (3.9%) View
NikR_C (PF08753) 5073 (3.0%) View
ACT_3 (PF10000) 862 (0.5%) View
Total: 9 Total: 169058 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 28 interactions for this clan. More...

Interacting families
A B
2-Hacid_dh ACT
AA_kinase ACT
ACT_7
ACT AA_kinase
ACT
ACT_7
Biopterin_H
Formyl_trans_N
PDT
ACT_3 ACT_3
ACT_7
ACT_4 ACT_4
ACT_5 ACT_5
ALS_ss_C
ACT_6 ACT_6
ACT_7 AA_kinase
ACT
ACT_3
ACT_7
ALS_ss_C ACT_5
Formyl_trans_N ACT
Homoserine_dh ACT
NikR_C NikR_C
RHH_1
PALP Thr_dehydrat_C
PDT ACT
RHH_1 NikR_C
Thr_dehydrat_C Thr_dehydrat_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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