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216  structures 111  species 3  interactions 1468  sequences 21  architectures

Clan: Defensin (CL0075)


Defensin/myotoxin-like superfamily Add an annotation

This clan includes diverse defensins as well as myotoxins.

This clan contains 15 families and the total number of domains in the clan is 1468. The clan was built by A Bateman.


This clan contains the following 15 member families:

DEFB136 Defensin_1 Defensin_3 Defensin_4 Defensin_beta Defensin_beta_2 Defensin_big Defensin_int Defensin_RK-1 Inhibitor_I68 Laterosporulin Meleagrin Myotoxins Pelovaterin Toxin_4

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Defensin_beta_2 (PF13841) 642 (43.7%) View
Defensin_beta (PF00711) 562 (38.3%) View
Defensin_1 (PF00323) 140 (9.5%) View
Meleagrin (PF08189) 61 (4.2%) View
DEFB136 (PF17333) 28 (1.9%) View
Defensin_3 (PF08131) 11 (0.7%) View
Toxin_4 (PF00706) 9 (0.6%) View
Defensin_big (PF14862) 7 (0.5%) View
Defensin_RK-1 (PF17860) 4 (0.3%) View
Laterosporulin (PF17861) 1 (0.1%) View
Pelovaterin (PF17859) 1 (0.1%) View
Defensin_int (PF17858) 1 (0.1%) View
Inhibitor_I68 (PF10468) 1 (0.1%) View
Myotoxins (PF00819) 0 (0.0%) View
Defensin_4 (PF07936) 0 (0.0%) View
Total: 15 Total: 1468 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
Defensin_1 Defensin_1
Defensin_beta Defensin_beta
Peptidase_M14 Inhibitor_I68


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...