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40  structures 2471  species 5  interactions 21064  sequences 335  architectures

Clan: MBD-like (CL0081)

Summary

MBD-like DNA-binding domain Add an annotation

This clan contains proteins with a distinctive three stranded DNA-binding domain [1].

This clan contains 10 families and the total number of domains in the clan is 21064. The clan was built by A Bateman.

Literature references

  1. Connolly KM, Ilangovan U, Wojciak JM, Iwahara M, Clubb RT; , J Mol Biol 2000;300:841-856.: Major groove recognition by three-stranded beta-sheets: affinity determinants and conserved structural features. PUBMED:10891272 EPMC:10891272

Members

This clan contains the following 10 member families:

AP2 Arm-DNA-bind_1 Arm-DNA-bind_2 Arm-DNA-bind_3 Arm-DNA-bind_4 Arm-DNA-bind_5 CedA Integrase_DNA MBD MBDa

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AP2 (PF00847) 12115 (57.5%) View
Arm-DNA-bind_3 (PF13356) 3204 (15.2%) View
MBD (PF01429) 2181 (10.4%) View
Arm-DNA-bind_5 (PF17293) 1548 (7.3%) View
Arm-DNA-bind_4 (PF14657) 927 (4.4%) View
MBDa (PF16564) 400 (1.9%) View
Arm-DNA-bind_2 (PF12167) 305 (1.4%) View
Integrase_DNA (PF02920) 279 (1.3%) View
Arm-DNA-bind_1 (PF09003) 80 (0.4%) View
CedA (PF10729) 25 (0.1%) View
Total: 10 Total: 21064 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
AP2 AP2
Arm-DNA-bind_1 Arm-DNA-bind_1
Phage_int_SAM_1
Arm-DNA-bind_3 Arm-DNA-bind_3
Phage_int_SAM_1 Arm-DNA-bind_1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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