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562  structures 2583  species 25  interactions 6990  sequences 515  architectures

Clan: ADP-ribosyl (CL0084)

Summary

ADP-ribosylation Superfamily Add an annotation

The members of this clan all represent ADP-ribosylating catalytic domains. The structurally conserved regions are located at the NAD binding region [1]. According to SCOP, the ADP-ribosylation domain is thought to have an "unusual fold".

This clan contains 7 families and the total number of domains in the clan is 6990. The clan was built by RD Finn.

Literature references

  1. Ame JC, Spenlehauer C, de Murcia G; , Bioessays 2004;26:882-893.: The PARP superfamily. PUBMED:15273990 EPMC:15273990

Members

This clan contains the following 7 member families:

ADPrib_exo_Tox Anthrax-tox_M ART Diphtheria_C Enterotoxin_a PARP Pertussis_S1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PARP (PF00644) 3404 (48.7%) View
ADPrib_exo_Tox (PF03496) 2030 (29.0%) View
ART (PF01129) 679 (9.7%) View
Enterotoxin_a (PF01375) 554 (7.9%) View
Pertussis_S1 (PF02917) 267 (3.8%) View
Anthrax-tox_M (PF09156) 29 (0.4%) View
Diphtheria_C (PF02763) 27 (0.4%) View
Total: 7 Total: 6990 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 25 interactions for this clan. More...

Interacting families
A B
ADPrib_exo_Tox Actin
ADPrib_exo_Tox
Anthrax-tox_M Anthrax-tox_M
ATLF
Arf Enterotoxin_a
ART ART
ATLF ADPrib_exo_Tox
Anthrax-tox_M
Diphtheria_C Diphtheria_C
Diphtheria_R
Diphtheria_T
Diphtheria_R Diphtheria_C
Enterotoxin_a Enterotoxin_a
Enterotoxin_b
Enterotoxin_b Enterotoxin_a
Exo_endo_phos Pertussis_S1
LT-IIB Enterotoxin_a
PARP PARP
PARP_reg
PARP_reg PARP
Pertussis_S1 Pertus-S4-tox
Pertus-S5-tox
Pertussis_S2S3
Pertussis_S2S3 Pertussis_S1
Ras ADPrib_exo_Tox

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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