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736  structures 878  species 32  interactions 4235  sequences 413  architectures

Clan: ADP-ribosyl (CL0084)

Summary

ADP-ribosylation Superfamily Add an annotation

The members of this clan all represent ADP-ribosylating catalytic domains. The structurally conserved regions are located at the NAD binding region [1]. According to SCOP, the ADP-ribosylation domain is thought to have an "unusual fold".

This clan contains 12 families and the total number of domains in the clan is 4235. The clan was built by RD Finn.

Literature references

  1. Ame JC, Spenlehauer C, de Murcia G; , Bioessays 2004;26:882-893.: The PARP superfamily. PUBMED:15273990 EPMC:15273990

Members

This clan contains the following 12 member families:

ADPrib_exo_Tox Anthrax-tox_M ART AvrPphF-ORF-2 Diphtheria_C DUF2441 DUF952 Enterotoxin_a Exotox-A_cataly PARP Pertussis_S1 PTS_2-RNA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PARP (PF00644) 2475 (58.4%) View
PTS_2-RNA (PF01885) 711 (16.8%) View
ART (PF01129) 421 (9.9%) View
DUF952 (PF06108) 396 (9.4%) View
ADPrib_exo_Tox (PF03496) 100 (2.4%) View
Enterotoxin_a (PF01375) 87 (2.1%) View
Pertussis_S1 (PF02917) 21 (0.5%) View
DUF2441 (PF10386) 18 (0.4%) View
AvrPphF-ORF-2 (PF09143) 3 (0.1%) View
Exotox-A_cataly (PF09009) 1 (0.0%) View
Anthrax-tox_M (PF09156) 1 (0.0%) View
Diphtheria_C (PF02763) 1 (0.0%) View
Total: 12 Total: 4235 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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