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583  structures 19616  species 23  interactions 139592  sequences 301  architectures

Clan: FAD_DHS (CL0085)

Summary

DHS-like NAD/FAD-binding domain Add an annotation

The members of this family adopt a Rossmann fold, similar to CLAN:CL0063. However, the members of this family are distinguished in that the FAD/NAD cofactor is bound in the opposite direction. In this arrangement, the adenosine moiety is found bound at the second half of the fold. In addition, the conserved GxGxxG motif found in classical NADP binding Rossmann folds is absent. Finally, another distinguishing characteristic is the formation of an internal hydrogen bond in the FAD molecule [1].

This clan contains 9 families and the total number of domains in the clan is 139592. The clan was built by RD Finn.

Literature references

  1. Dym O, Eisenberg D; , Protein Sci 2001;10:1712-1728.: Sequence-structure analysis of FAD-containing proteins. PUBMED:11514662 EPMC:11514662

Members

This clan contains the following 9 member families:

CO_dh DS DUF4917 ETF_alpha PNTB SIR2 SIR2_2 TPP_enzyme_M TPP_enzyme_M_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TPP_enzyme_M (PF00205) 73541 (52.7%) View
SIR2 (PF02146) 21314 (15.3%) View
ETF_alpha (PF00766) 18500 (13.3%) View
PNTB (PF02233) 9833 (7.0%) View
TPP_enzyme_M_2 (PF16582) 9103 (6.5%) View
SIR2_2 (PF13289) 5020 (3.6%) View
DS (PF01916) 1741 (1.2%) View
DUF4917 (PF16263) 393 (0.3%) View
CO_dh (PF02552) 147 (0.1%) View
Total: 9 Total: 139592 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 23 interactions for this clan. More...

Interacting families
A B
Acyl-CoA_dh_1 ETF_alpha
Acyl-CoA_dh_M ETF_alpha
AlaDh_PNT_C PNTB
AlaDh_PNT_N PNTB
CO_dh CO_dh
DS DS
DUF592 SIR2
ETF ETF_alpha
ETF_alpha ETF
Fer4_7 CO_dh
PNTB AlaDh_PNT_C
AlaDh_PNT_N
PNTB
Prismane CO_dh
SIR2 AMP-binding_C
DUF592
Histone
SIR2
TPP_enzyme_C TPP_enzyme_M
TPP_enzyme_M TPP_enzyme_C
TPP_enzyme_M
TPP_enzyme_N
TPP_enzyme_N TPP_enzyme_M

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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