Sequence alignment for CL0086

PF01619

PROD_HUMAN/259-582HQMAVEQGQAGLAAMDTK.LEVAVLQESVAKLGIASR.AEIEDWFTAETLGVSGTMDLLDWSSLIDSRTKLS........
PROD_CAEEL/276-595LTGGMSLQEG....RLT....SQEFYKRLGELGVKTDTESVKKFFDEVDFDSDGIVDLHGWNHILDDHVKLG........
O50444_MYCTU/40-320VPGDTLDDVVDIVTALR....DSGRYLSIDYLG.........ENVTDADDAAAAVRAYLGLLDVLGRRGDIA........
PROD_DROME/337-657GGQGNVLTHHKTIKDLE.........KYYATLGDNK...DVKEFLNNVTSDKEGILHLFPWSGIVDEDSQLS........
PUTA_ECOLI/260-574VTGETIAEALANARKLE....EKGFRYSYDMLG.........EAALTAADAQAYMVSYQQAIHAIGKASNGR........
O24897_HELPY/119-428LDQEESQLKERILKRKN.....EKIILNVNFIG.........EEVLGEEEANARFEKYSQALKSNYIQYIS.........
Q52711_RHOCA/168-473VLGETIEKALERAEKRE....AEGYTFSYDMLG.........EAALTAADAERYRLAYAQAITAIGKAATRG........
P74275_SYNY3/128-447IAGETIAQVIKTVERLR....KEKMGFTIDLLG.........EAVITESEAAEYWQNYLDLMAQLSQQAKSWSKVPQIDQ
PROD1_ARATH/167-486SCDDNMQQFIRTIEAAKS.LPTSHFSSVVVKIT..........AICPISL.LKRVSDLLRWEYKSPNFKLSW........
Q44334_RHIRD/198-509VTGETIGEAIKRSKPLE....EQGFQYSYDMLG.........EAATTAKDAERYYKDYENAIHAIGKASAGR........
Q59206_BRAJP/168-475VLGETIEQALERGKPRS....GQKTRYSFDMLG.........EGARTAADARRYFDAYASAIETIGKAAGNH........
PROD1_BACSU/32-302VAGDTIESAVKTVKRLN....RSGLCATIDYLG.........EYAASEKEANQVAEECKKAIQAIAEHQLN.........
PUT1_YEAST/145-464SEGTKSLSSTPVDQIVKETISSVHNILLPNIIG........QLESKPINDIAPGYIALKPSALVDNPHEVLY........
Q59426_ECOLX/258-571VTGETIAQALANARKLE....EKGFRYSYDMLG.........ERALTAADAQAYMVSYQQAIHAIGKASNGR........
PROD2_BACSU/33-303IGGNDFNSSIPTIRQLN....SQGLSVTVDHLG.........EFVNSAEVARERTEECIQTIATIADQELN.........

PF02219

MTHR2_YEAST/6-298----KLEQH.RQTSGKP----TYSFEYFVPKTT---------QGVQNLYDRMDRMYEASLPQFIDITWNAGG--------
MTHR1_SCHPO/6-292----KLL.HPDW.KEKV----TYSYEFFPPKTS---------TGVQNLYNRIDRMKTWGRPMFVDVTWGAGG--------
METF_STRLI/15-300----TVRDILA..TGKT----TYSFEFSAPKTP---------KGEKNLWSALRRVEAVA.PDFVSVTYGAGG--------
METF_AQUAE/2-288----KIGDILR..KGVF----SISFEFFPPKTE---------EGERQLFETIRKLEKLN.PTFVSVTYGAGG--------
MTHR2_SCHPO/6-305----LIDKIPN...GNA----FYSFEYFPPKTT---------VGLENLSSRITRMSRNMMPLFSSVTWGTAG--------
MTHR_CAEEL/61-350----RIERLID..EKQQ----FFSLEFFPPRFV---------NGVPNFLERVERLSEGG.SVFVDMTWHMGS--------
METF_HAEIN/9-289----TLNQHIADFNKKI----NVSFEFFPPKNE---------KMETLLWDSIHRLKVLK.PKFVSVTYGANS--------
MTHR1_YEAST/6-302----LYHAR.....ASP----FISLEFFPPKTE---------LGTRNLMERMHRMT.ALDPLFITVTWGAGG--------
P73677_SYNY3/47-334----RFRQAAE..AKEF----LITAEVTPPKGG---------NPERMLAVAAKLRGRVH...GVNVTDGSRA--------
MTHR_HUMAN/48-337----KMRRRLE..SGDK----WFSLEFFPPRTA---------EGAVNLISRFDRMAAGG.PLYIDVTWHPAG--------
METF_PECCC/11-291----ALNQSLAELQGRI----NVSFEFFPPRTS---------DMEETLWSSIDRLSSLK.PKFVSVTYGANS--------
MTHR2_ARATH/6-301----KIQSLAD..EGKT----AFSFEFFPPKTE---------DGVDNLFERMDRMVAYG.PTFCDITWGAGG--------

PF01619

PROD_HUMAN/259-582...KHLVVPNAQT.GQLEPLLSRF.....TEEEEL...QMTRMLQRMDVLAKKATEMGVRLMVDAEQTYFQPAI......
PROD_CAEEL/276-595...QLFQVLNIKT.GSLEPLIQNL.....SNEEEQ...EFRNMVRRTLDVAEYAIEKGVRIMVDAEQTYLQPAI......
O50444_MYCTU/40-320...CDGVRP.......LEVSLKLS.....ALGQALDRDGQKIALDNARAICERAERVGAWVTVDAEDHTTTDST......
PROD_DROME/337-657...DTFRVPDPQTGQMRRLISQIP.....PKEEEM....FRNMIRRLNTIVKAAADLDVRIMVDAEQTYFQPAI......
PUTA_ECOLI/260-574...GIYEGPGISI.KLSALHPRYS.....RAQYDR...VMEELYPRLKSLTLLARQYDIGINIDAEESDRLEIS......
O24897_HELPY/119-428.....IKITTIFS.QINILDFEYS.....KKEIVK....RLDALYALALEEEKKQGMPKFINLDMEEFRDLELT......
Q52711_RHOCA/168-473...SIAANPGISI.KLSALHPRYE.....VAQEAR...VMAELVPVVRDLARAAARAGIALHIDAEEQDRLALS......
P74275_SYNY3/128-447ADGEILPQVQVSV.KLTAFYSQFD.....PLDPAG...SKAKVCERIRELLRRAQELGVAVHFDMEQYHYKDLI......
PROD1_ARATH/167-486...KLKSFP.VFS.ESSPLYHTNSEPEPLTAEEER...ELEAAHGRIQEICRKCQESNVPLLIDAEDTILQPAIDYMAYS
Q44334_RHIRD/198-509...GIYGGPGISI.KLSALHPRYA.....RVQAER...VMAELLPRVKSLMLLSKKYDIGLNIDAEEADRLELS......
Q59206_BRAJP/168-475...ALPDRPGISV.KLSALHPRFE.....AISRAR...VMVELVPQLLDLAQRGKAHDLNFTVDAEEADRLELS......
PROD1_BACSU/32-302................SELSLKLT.....SIGLDL...SEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQT......
PUT1_YEAST/145-464...N.FSNPAYKA.QRDQLIENCS.....KITKEIFELNQSLLKKYPERKAPFMVSTIDAEKYDLQENGVYELQ......
Q59426_ECOLX/258-571...GIYEGPASRL.SCPPCIHAIA.....RAIRS....GMEELYPRLKSLTLLARQSTLGLNIDVRKRRIVWRS......
PROD2_BACSU/33-303................SHVSLKMT.....SLGLDI...DMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKT......

PF02219

MTHR2_YEAST/6-298-.....GRLSHLSTDLVATAQSVL-----GLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRDAE------
MTHR1_SCHPO/6-292-.....TSS.ELTPGIVNVIQTDF-----EVDTCMHLTCTNMSTEMIDAALKRAHETGCRNILALRGDPVKDTD------
METF_STRLI/15-300-.....STR.AGTVRETQQIVADT-----TLTPVAHLTAVDHSVAELRNIIGQYADAGIRNMLAVRGDPPGDPN------
METF_AQUAE/2-288-.....STR.DRTRNIVQKIHEET-----NLTVMAHLTCIAHTREELIDILQDYKNIGIENILALRGDVPRD.K------
MTHR2_SCHPO/6-305-.....STA.EVSIYLAKMLEQHH-----KIPACLHLTCTNVDKAIIDKALETAKEYGIRNILALRGDPPLNSD------
MTHR_CAEEL/61-350-DPANVDKV.TSSSSIAASMLDYC-----GVDTMLHMTCVQYNKADTLKHLEQAKAMGLRSILALRGDLPPGTE------
METF_HAEIN/9-289-.....GER.DRTHGIVKAIKQET-----GLEAAPHLTGIDATPEELKQIARDYWDSGIRRIVALRGDEPKG..------
MTHR1_YEAST/6-302-.....TTA.EKTLTLASLAQQTL-----NIPVCMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGED------
P73677_SYNY3/47-334-......VL.RMSSIAACVLLQQR-----GIEAICQMTCRDRNLIGLQADLMGAYALGLRNVLALTGDPLKAGD------
MTHR_HUMAN/48-337-DPG.SDKE.TSSMMIASTAVNYC-----GLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGD.PIGDQ------
METF_PECCC/11-291-.....GER.DRTHSIIKTIKERT-----GLEAAPHLTCIDASREQLREIAQDYWESGIRHIVALRGDLPQE..------
MTHR2_ARATH/6-301-.....STA.DLTLDIASRMQNVV-----CVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQD------

PF01619

PROD_HUMAN/259-582SRLTLE..MQRKFNVEKPLIFNTYQCYLK-----DAYDNVTLDVELARREGWC....FGAKLVRGAYLAQERARAAEIGY
PROD_CAEEL/276-595SKITIE..MMKKYNKGRGNIFNTYQAYLK-----GTLQNMEADMQVARREGWH....FGAKLVRGAYMEQERARAKAIGY
O50444_MYCTU/40-320LSISGD......LRVDFPWLGTVVQAYLR-----RTLADCAELAAVGAR..........VRLCKGAYDEPAS........
PROD_DROME/337-657SRITLE..MMRKYNKDKAIVFNTYQCYLR-----ETFREVNTDLEQAKRQNFY....FGAKLVRGAYMDQERDRAKSLGY
PUTA_ECOLI/260-574LDLLEK.LCFEPELAGWNGIGFVIQAYQK-----RCPLVIDYLIDLATRSRRR....LMIRLVKGAYWDSEIKRAQMDGL
O24897_HELPY/119-428VESFME.....SIAKFDLNAGIVLQAYIP-----DSYEYLKKLHAFSKERVLKGLKPIKIRFVKGANMESEETIASVK.D
Q52711_RHOCA/168-473LRVMAA.VIADPETAGWEGFGAVVQAYGK-----RAGAAIDALAAMARAAGRR....INIRLVKGAYWDAEMKRAQVEGH
P74275_SYNY3/128-447LNILKE.LLVEEEFRSRTDVGITMQAYLR-----DSTEDLEALIPWAKHRGYP....VTVRLVKGAYWDQETIKAQQN.H
PROD1_ARATH/167-486SAIMFN......ADKDRPIVYNTIQAYLR-----DAGERLHLAVQNAEKENVP....MGFKLVRGAYMSSEASLADSLGC
Q44334_RHIRD/198-509LDLLEE.LALDKDLAGWNGLGFVVQAYGR-----RCPFVLDYIIDLAQRAGRR....IMVRLVKGAYWDAEIKRAQVDGL
Q59206_BRAJP/168-475LDVIAA.TLADPSLKGWDGFGLAIQAYQK-----RASAVIDYVDALARAHDRK....LMVRLVKGAYWDTEIKRAQERGL
PROD1_BACSU/32-302LSIYRQ......CKQEFEKLGTVIQAYLY-----RAAEDIRKMRDLKP..........NLRLVKGAYKESAA........
PUT1_YEAST/145-464RILFQK...FNPTSSKLISCVGTWQLYLR-----DSGDHILHELKLAQENGYK....LGLKLVRGAYIHSEKNRNQ..II
Q59426_ECOLX/258-571RSICWKNSASNPNWRAGTGIGFVIQAYQK-----RCPLVIVYLVDLASRSRRP....VMIRLVKGAYWDSEINARKWKGW
PROD2_BACSU/33-303LDIFKD......FRKKYEHVSTVLQAYLY-----RTEKDIDDLDSLNP..........FLRLVKGAYKESEK........

PF02219

MTHR2_YEAST/6-298N.WTPV------EGG..FQYAKDLIKYIKS....KYGDHFAIGVAGYP..ECHP....ELPNKD...VKLDLEYLKQKID
MTHR1_SCHPO/6-292..WTEG------ESG..FRYASDLVRYIRT....HYNDEFCIGVAGYP..EGY......SPDDD...IDESIKHLKLKVD
METF_STRLI/15-300ADWIAH------PEG..LTYAAELVRLIK.....ESGD.FCVGVAAFP..EMHP......RSAD...WDTDVTNFVDKCR
METF_AQUAE/2-288PDWRPP------KGA..CKYAKELVELIRK....EFGDWFSIGVASYP..EGHP......ESPN...LEWEVKYFKEKVE
MTHR2_SCHPO/6-305H.WEGK------VSE..FEHAVDLVRYIRE....KYGDYFCIGVAAYP..EGHVDSNVPELSKD...PLRDIPFLIEKVE
MTHR_CAEEL/61-350..LEDT------H.Q..FR.ALDMIRWIRE....EYGNYFSIGCAGYP..LGHP......QAPS...YKADLMYLKAKCD
METF_HAEIN/9-289..YAKK------P.....FYASDLVELLR.....SVAD.FDISVAAYP..EVHP......EAKS...AQADLINLKRKID
MTHR1_YEAST/6-302W.LDSQ------SNESPFKYAVDLVRYIKQ....SYGDKFCVGVAAYP..EGHCEGEAEGHEQD...PLKDLVYLKEKVE
P73677_SYNY3/47-334HAKARP------VYDLESVRLLSLIRSLNQGLDFNQAPLVDGRLDLFPGAAVDP......QLKS...WSGLQSRFERKLT
MTHR_HUMAN/48-337..WEEE------EGG..FNYAVDLVKHIRS....EFGDYFDICVAGYP..KGHP......EAGS...FEADLKHLKEKVS
METF_PECCC/11-291..GGKP------D.....MYAADLVSLLK.....EVGD.FDISVAAYP..EVHP......EAKS...AQADLINLKHKID
MTHR2_ARATH/6-301K.FVQV------EGG..FDCALDLVNHIRS....KYGDYFGITVAGYP..EAHPDVIGENGLASNEAYQSDLEYLKKKID

PF01619

PROD_HUMAN/259-582EDPINPTYEATNAMYHR...CLDYVLEELKHN..----..AKAKVMVASHNEDTVRFALRRMEELG.LHPADHQVYFGQL
PROD_CAEEL/276-595EDPINDNFEATSKMYES...CLTRIADEVHRRG.----.KTNVSVMVASHNEDTVRFALNLMKEKC.ISPSERVMCMAQL
O50444_MYCTU/40-320...VAYRDAAQVTDSYL...RCLRVLTAGR....----....GYPMVATHDPVIIAAVPGITRESG.RSQ..GDFEYQML
PROD_DROME/337-657PDPVNPTFEATTDMYHRTLSECLRRIKLMKDCDD----DARKIGIMVASHNEDTVRFAIQQMKEIG.ISPEDKVICFGQL
PUTA_ECOLI/260-574EGYPVYTRKVYTDVSYL...ACAKKLLAVPNL..----....IYPQFATHNAHTLAAIYQLAGQNY.YP...GQYEFQCL
O24897_HELPY/119-428WALPTFSNKQDTDSNYN...KMLDFVLEGDNY..----..KYIHIGAASHNIFEIAYVYTRIHAIN.DPVVLEHFSFEML
Q52711_RHOCA/168-473PGFPLFTSKTGTDVAYI...CLAAKLFGLNDC..----....IYPQFATHNAHTVAAVLEMAAG........RPFEFQRL
P74275_SYNY3/128-447WQIPVYVEKAQTDANYE...RMTRLLLENHEY..----....LYAAIGSHNVRSQALACAIAEELN.IPK..RRYEMQIL
PROD1_ARATH/167-486KSPVHDTIQDTHSCYND...CMTFLMEKASNG..----..SGFGVVLATHNADSGRLASRKASDLG.IDKQNGKIEFAQL
Q44334_RHIRD/198-509EDFPVFTRKVHTDVSYI...ACARKLLAARDV..----....VFPQFATHNAQSMATIYHLAGPDF.KL...GDYEFQCL
Q59206_BRAJP/168-475DGYPVFTRKAMTDLNYV...ACASKLLALRPR..----....IFPQFATHNALTVATVLEMAEGS.......SGFEFQRL
PROD1_BACSU/32-302V...AFPDKRGTDLHFQ...SLIKLQLLSG....----....NYTAVATHDDDIIAFTKQLVAEHQ.IPA..SQFEFQML
PUT1_YEAST/145-464FGDKTGTDENYDRIITQ...VVNDLIINGEDS..----..YFGHLVVASHNYQSQMLVTNLLKSTQDNSYAKSNIVLGQL
Q59426_ECOLX/258-571RLSGLYPQSVYR.CLLS...GLREKTARRPNL..----....IYPQFASHNAHTLAAIYHLAGQNY.YP...GQYEFQCL
PROD2_BACSU/33-303V...AFPEKSDVDENYK...KIIRKQLLNG....----....HYTAIATHDDKMIDFTKQLAKEHG.IAN..DKFEFQML

PF02219

MTHR2_YEAST/6-298AGGDFIITQMFYDVD-----NFINWCSQVRAAGM....DVPIIPGIMPITTYAAFLRRAQWG.QIS-IPQ-----HFSSR
MTHR1_SCHPO/6-292EGADFIVTQMFYDVD-----NFIAWVDKVRAAGI....NIPIFPGIMPIQAWDSFIRRAKWS.GVK-IPQ-----HFMDT
METF_STRLI/15-300AGADYAITQMFFQPD-----SYLRLRDRVAAAGC....ATPVIPEVMPVTSVKMLERLPKLS.NAS-FPA-----ELKER
METF_AQUAE/2-288AGADFSITQMFFVND-----YYYRFVEMCKNAGI....DISIIPGIMPITNFKQIRKFASLC.GAT-IPQ-----SLIEK
MTHR2_SCHPO/6-305AGADFIITQIFYEPE-----AFIKFENFVRNHSSNALRNIPIIPAIMPIQSYGSLKRMTRLC.GCS-VPS-----SLMQR
MTHR_CAEEL/61-350AGANFVITQLFFEAE-----TFEKFVRDCREIGI....TQPIIPGIMPIMGYESIKRIAKLS.QLE-IPQ-----HILDD
METF_HAEIN/9-289AGANHVITQFFFDIE-----NYLRFRDRCASIGI....DTEIVPGILPVTNFKQLQKMASFT.NVK-IPA-----WLVKA
MTHR1_YEAST/6-302AGADFVITQLFYDVE-----KFLTFEMLFRERIS...QDLPLFPGLMPINSYLLFHRAAKLS.HAS-IPP-----AILSR
P73677_SYNY3/47-334AGAQFFQSQLITDFD-----RLDKFMTQVAVGCG.....KPILAGIFLFKSAKNATFIKRVVPGVN-IPD-----ALIDR
MTHR_HUMAN/48-337AGADFIITQLFFEAD-----TFFRFVKACTDMGI....TCPIVPGIFPIQGYHSLRQLVKLS.KLE-VPQ-----EIKDV
METF_PECCC/11-291AGANRAITQFFFDVE-----SYLRFRDRCVATGI....DVEIVPGILPVSNFKQLQKFATMT.NVR-VPN-----WMTTM
MTHR2_ARATH/6-301AGADLIVTQLFYDTD-----IFLKFVNDCRQIGI....SCPIVPGIMPINNYRGFLRMTGFC.KTK-IPV-----EVMAA

PF01619

PROD_HUMAN/259-582LGMCDQISFPLGQAG......YPVYKYVPYG--PV...MEVLPYLSRRALENSSLMKGTHRERQLL
PROD_CAEEL/276-595YGMCDQVSFSLGQAG......FSVYKYLPYG--PV...EEVLPYLSRRALENGSVLKKANKERDLL
O50444_MYCTU/40-320YGVRDDEQRRLTGAG......NHVRVYVPFG--.....TRWYGYFLRRLAERPANLAFFLRALTDR
PROD_DROME/337-657LGMCDYITFPLGQAG......YSAYKYIPYG--PV...EEVLPYLSRRAQENKGVLKKIKKEKRLL
PUTA_ECOLI/260-574HGMGEPLYEQVTGKVADGKLNRPCRIYAPVG--TH...ETLLAYLVRRLLENGANTSFVNRIADTS
O24897_HELPY/119-428EGMSLQASQELKEMH.......KLILYAPVC--DEAHFNNAIAYLVRRLDENTSSDNFMKAFFNLK
Q52711_RHOCA/168-473HGMGARLHDIVLRETG....G.RCRIYAPVG--AH...RDLLAYLVRRLLENGANSSFVNQIVNES
P74275_SYNY3/128-447YGMGEPLARAIVKRG......HRVRVYAPYG--RL...LPGMAYLIRRLLENTANSSFLRQNLEER
PROD1_ARATH/167-486YGMSDALSFGLKRAG......FNVSKYMPFG--PV...ATAIPYLLRRAYENRGMMATGAHDRQLM
Q44334_RHIRD/198-509HGMGEPLYSEVVGKKK...LDRPCRFYAPVG--TH...ETLLAYLVRRLLENGANSSFVNRIADPA
Q59206_BRAJP/168-475HGMGEALYEQLAKDHA...DI.AYRTYAPVG--SH...RDLLAYLVRRLLENGANSSFVAQAADYR
PROD1_BACSU/32-302YGIRPERQKELAKEG......YRMRVYVPYG--.....TDWFSYFMRRIAERPANAAFVLKGILKK
PUT1_YEAST/145-464LGMADNVTYDLITNHG....AKNIIKYVPWG--PP...LETKDYLLRRLQENGDAVRSDNGWPLIK
Q59426_ECOLX/258-571HGMGEPLYEQVTGKVADGKLNRPCRIYAPVG--TH...ETLLAYLVRRLLENGANTSFVNRIADAT
PROD2_BACSU/33-303YGMRSQTQLSLVKEG......YNMRVYLPYG--.....EDWYGYFMRRLAERPSNIAFAFKGMTKK

PF02219

MTHR2_YEAST/6-298LD.PIKDDDELVRDIGTNLIVEMCQKLLDSG..YV---SHLHIYTMNLEKAPLMILERLN------
MTHR1_SCHPO/6-292LV.PVKDDDEGVRERGVELIVEMCRKLIASG...I---TRLHFYTMNLEKAVKMIIERLG------
METF_STRLI/15-300IL.TAKDDPAAVRSIGIEFATEFCARLLAEG...V---PGLHFITLNNSTATLEIYENLG------
METF_AQUAE/2-288LE.KVEDKPEEVKKIGIEFAINQCLDLIEHG...V---PGLHFYTLNKSDATLKIYEAIK------
MTHR2_SCHPO/6-305LN.AAKPDDEAIKNIGVEHIVDMIKKIMDNVQGRV---HGFHFCTLNLERSVALILKNSG------
MTHR_CAEEL/61-350LE.PIKHDDDAVQKYGTERCIEMCRRLLDNG..TA---PSIHLYTMNREGSIREILKSLG------
METF_HAEIN/9-289YD.GLDNDPTTRNLVAASVAMDMVKILSREG...V---NDFHFYTLNRSELTYAICHMLG------
MTHR1_YEAST/6-302FPPEIQSDDNAVKSIGVDILIELIQEIYQRTSGRI---KGFHFYTLNLEKAIAQIVSQSP------
P73677_SYNY3/47-334LA...RAEDPLKEGVAIAAEQVKLAKELCQG....---..VHLMAIKKEELIPEILDQAG------
MTHR_HUMAN/48-337IE.PIKDNDAAIRNYGIELAVSLCQELLASG..LV---PGLHFYTLNREMATTEVLKRLG------
METF_PECCC/11-291FD.GLDNDPETRKMVGASIAMDMVKILSREG...V---KDFHFYTLNRAELSYAICHTLG------
MTHR2_ARATH/6-301LE.PIKDNEEAVKAYGIHLGTEMCKKMLAHG...V---KSLHLYTLNMEKSALAILMNLG------

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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