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470  structures 9074  species 11  interactions 85555  sequences 945  architectures

Clan: Alk_phosphatase (CL0088)


Alkaline phosphatase-like Add an annotation

The members of this clan all share a common structure of their catalytic domains, which contain conserved metal binding residues [1].

This clan contains 10 families and the total number of domains in the clan is 85555. The clan was built by RD Finn.

Literature references

  1. Galperin MY, Jedrzejas MJ; , Proteins 2001;45:318-324.: Conserved core structure and active site residues in alkaline phosphatase superfamily enzymes. PUBMED:11746679 EPMC:11746679


This clan contains the following 10 member families:

Alk_phosphatase DUF1501 DUF229 DUF4976 Metalloenzyme PglZ Phosphodiest Phosphoesterase Sulfatase Sulfatase_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Sulfatase (PF00884) 35474 (41.5%) View
Phosphodiest (PF01663) 14300 (16.7%) View
Metalloenzyme (PF01676) 10110 (11.8%) View
Alk_phosphatase (PF00245) 5867 (6.9%) View
Phosphoesterase (PF04185) 5816 (6.8%) View
DUF1501 (PF07394) 4898 (5.7%) View
DUF4976 (PF16347) 3851 (4.5%) View
DUF229 (PF02995) 2060 (2.4%) View
Sulfatase_C (PF14707) 1640 (1.9%) View
PglZ (PF08665) 1539 (1.8%) View
Total: 10 Total: 85555 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
Alk_phosphatase Alk_phosphatase
Metalloenzyme iPGM_N
PhosphMutase Metalloenzyme
Phosphodiest Endonuclease_NS
Phosphoesterase Phosphoesterase
Somatomedin_B Phosphodiest
Sulfatase Sulfatase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...